Lentiviral gene transfer into peripheral blood-derived CD34+ NOD/SCID-repopulating cells

Blood

Volumn 99, Issue 2, 2002, Pages 709-712

  Scherr, Michaela ^a,b,c   Battmer, Karin ^a,b,c   Blömer, Ulrike ^a,b,c   Schiedlmeier, Bernd ^a,b,c   Ganser, Arnold ^a,b,c   Grez, Manuel ^a,b,c   Eder, Matthias ^a,b,c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CYTOKINE; GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; LENTIVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; BONE MARROW CELL; CELL POPULATION; CLINICAL PROTOCOL; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; GENE TRANSFER; GENETIC CODE; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENE; VESICULAR STOMATITIS VIRUS;

EID: 0037079742     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.2.709     Document Type: Article

References (24)

1. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
2. Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin
3. + cells in non-obese/severe combined immunodeficient mice
4. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
5. Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles
6. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors
7. + cells with a human immunodeficiency virus type 1-based etroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein G
8. Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells
9. + cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors
10. - human hematopoietic cells by HIV-1-based lentiviral vectors
11. - cell transduction via lentivirus-based gene transfer vectors
12. - bone marrow and cord blood-derived SCID-repopulating cells with third-generation lentiviral vectors
13. The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cells
14. Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells
15. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay
16. Human cord blood cells as targets for gene transfer: Potential use in genetic therapies of severe combined immunodeficiency disease
17. High efficiency gene transfer to human hematopoietic SCID-repopulating cells under serum-free conditions
18. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
19. Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element
20. HIV-1 genome nuclear import is mediated by a central DNA flap
21. A third-generation lentivirus vector with a conditional packaging system
22. Quantitative determination of lentiviral vector particle numbers by real-time PCR
23. Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice
24. + cells transduced by a self-inactivating human immunodeficiency virus type 1 vector