Inhibition of granulocyte-macrophage colony-stimulating factor receptor function by a splice variant of the common β-receptor subunit

Blood

Volumn 98, Issue 9, 2001, Pages 2689-2696

  Wagner, Katharina ^a   Kafert Kasting, Sabine ^a   Heil, Gerhard ^a   Ganser, Arnold ^a   Eder, Matthias ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 5 RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CELL SURVIVAL; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENE CONSTRUCT; GENE SEQUENCE; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN EXPRESSION; RECEPTOR BLOCKING; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

EID: 0035525764     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.9.2689     Document Type: Article

References (47)

1. Gearing DP, King JA, Gough NM, Nicola NA. Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J. 1989;8:3667-3676.
2. Haysahida K, Kitamura T, Gorman DM, Arai KI, Yokota T, Miyajima A. Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GMCSF): reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci U S A. 1990;87:9655-9659.
3. Kitamura T, Sato N, Arai KI, Miyajima A. Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for human IL-3 and GM-CSF receptors. Cell. 1991;66:1165-1174.
4. Tavernier J, Devos R, Cornelis S, et al. A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF. Cell. 1991;66:1175-1184.
5. Eder M, Ernst TJ, Ganser A, et al, A low affinity chimeric human α/β-granulocyte-macrophage colony-stimulating factor receptor induces ligand-dependent proliferation in a murine cell line. J Biol Chem. 1994;269:30173-30180.
6. Muto A, Watanabe S, Miyajima A, Yokota T, Arai KI. The β subunit of human granulocyte-macrophage colony-stimulating factor receptor forms a homodimer and is activated via association with the α subunit. J Exp Med. 1996;183:1911-1916.
7. Bagley CJ, Woodcock JM, Stomski FC, Lopez AF. The structural and functional basis of cytokine receptor activation: lessons from the common β subunit of the granulocyte-macrophage colonystimulating factor, interleukin-3 (IL-3), and IL-5 receptors. Blood. 1997;89:1471-1482.
8. Woodcock JM, McClure BJ, Stomski FC, Elliott MJ, Bagley CJ, Lopez AF. The human granulocyte-macrophage colony-stimulating factor (GMCSF) receptor exists as a preformed complex that can be activated by GM-CSF, interleukin-3, or interleukin-5. Blood. 1997;90:3005-3017.
9. Rossjohn J, McKinstry WJ, Woodcock JM, et al. Structure of the activation domain of the GMCSF/IL-3/IL-5 receptor common β-chain bound to an antagonist. Blood. 2000;95:2491-2498.
10. Lia F, Rajotte D, Clark SC, Hoang T. A dominant negative granulocyte-macrophage colony-stimulating factor receptor α chain reveals the multimeric structure of the receptor complex. J Biol Chem. 1996;271:28287-28293.
11. Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF. Identification of a Cys motif in the common β chain of the interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors. J Biol Chem. 1998;273:1192-1199.
12. Haman A, Cadieux C, Wilkes B, et al. Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly. J Biol Chem. 1999;274:34155-34163.
13. Sakamaki K, Miyajima I, Kitamura T, Miyajima A. Critical cytoplasmic domains of the common β subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J. 1992;11:3541-3549.
14. Sato N, Sakamaki K, Tereda N, Arai KI, Miyajima A. Signal transduction by the high-affinity GMCSF receptor: two distinct cytoplasmic regions of the common β subunit responsible for different signaling. EMBO J. 1993;12:4181-4189.
15. Quelle FW, Sato N, Witthuhn BA, et al. JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell Biol. 1994;14:4335-4341.
16. Ihle JN. Cytokine receptor signalling. Nature. 1995;377:591-594.
17. Itoh T, Liu R, Yokota T, Arai KI, Watanabe S. Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor. Mol Cell Biol. 1998;18:742-752.
18. Cohen GB, Ren R, Baltimore D. Modular binding domains in signaling proteins. Cell. 1995;80:237-248.
19. Pawson T. Protein modules and signalling networks. Nature. 1995;373:573-580.
20. Okuda K, Smith L, Griffin JD, Foster R. Signaling functions of the tyrosine residues in the βc chain of the granulocyte-macrophage colony-stimulating factor receptor. Blood. 1997;90:4759-4766.
21. Guthridge MA, Stomski FC, Barry EF, et al. Site-specific serine phosphorylation of the IL-3 receptor is required for hematopoietic cell survival. Mol Cell. 2000;6:99-108.
22. Gale RE, Freeburn RW, Khwaja A, Chopra R, Lynch DC. A truncated isoform of the human β chain common to the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 with increased mRNA expression in some patients with acute leukemia. Blood. 1998;91:54-63.
23. Tanner JW, Chen W, Young RL, Longmore GD, Shaw AS. The conserved box 1 motif of cytokine receptors is required for association with JAK kinases. J Biol Chem. 1995;270:6523-6530.
24. Kafert S, Luther S, Böll I, Wagner K, Ganser A, Eder M. Functional analysis of a single chain chimeric α/β-granulocyte-macrophage colony-stimulating factor receptor: importance of a glutamate residue in the transmembrane region. J Biol Chem. 1999;274:33064-33071.
25. Kafert S, Krauter J, Ganser A, Eder M. Differential quantitation of alternatively spliced messenger RNAs using isoform-specific real-time RT-PCR. Anal Biochem. 1999;269:210-213.
26. Evans CA, Pierce A, Winter SA, Spooncer E, Heyworth CM, Whetton AD. Activation of granulocyte-macrophage colony-stimulating factor and interleukin-3 receptor subunits in a multipotential hematopoietic progenitor cell line leads to differential effects on development. Blood. 1999;94:1504-1514.
27. McCormack MP, Gonda TJ. Novel murine myeloid cell lines that exhibit a differentation switch in response to IL-3 or GM-CSF, or to constitutively active mutants of the GM-CSF receptor β subunit. Blood. 2000;95:120-127.
28. Matsuguchi T, Zhao Y, Lilly MB, Kraft AS. The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor α subunit is essential for both GM-CSF-mediated growth and differentation. J Biol Chem. 1997;272:17450-17459.
29. , Jenkins BJ, D'Andrea R, Gonda TJ. Activating point mutations in the common β subunit of the human GM-CSF, IL-3, and IL-5 receptors suggest the involvement of β subunit dimerization and cell type-specific molecules in signalling. EMBO J. 1995;14:4276-4287.
30. Heaney ML, Golde DW. Soluble hormone receptors. Blood. 1993;82:1945-1948.
31. Baynes RD, Reddy K, Shih YJ, Skikne BS, Cook JD. Serum form of the erythropoietin receptor identified by sequence-specific peptide antibody. Blood. 1993;82:2088-2095.
32. Raines MA, Liu L, Quan SG, Joe V, DiPersio JF, Golde DW. Identification and molecular cloning of a soluble human granulocyte-macrophage colony stimulating factor receptor. Proc Natl Acad Sci U S A. 1991;88:8203-8207.
33. Vigon I, Mornon JP, Cocault L, et al. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci U S A. 1992;89:5640-5644.
34. Tavernier J, van der Heyden J, Verhee A, et al. Interleukin-5 regulates the isoform expression of its own receptor α-subunit. Blood. 2000;95:1600-1607.
35. Nakamura Y, Komatsu N, Nakauchi H. A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells. Science. 1992;257:1138-1141.
36. Lilly MB, Zemskova M, Frankel AE, Salo J, Kraft AS. Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit mediate activation of Jak/Stat signaling and differentation. Blood. 2001;97:1662-1670.
37. Nakamura Y, Nakauchi H. A truncated erythropoietin receptor and cell death: a reanalysis. Science. 1994;264:588-589.
38. Chiba S, Takahashi T, Takeshita K, et al. Selective expression of mRNA coding for the truncated form of erythropoietin receptor in hematopoietic cells and its decrease in patients with polycythemia vera. Blood. 1997;90:97-104.
39. Birnbaum RA, O'Marcaigh A, Wardak Z, et al. Nf1 and Gmcsf interact in myeloid leukemogenesis. Mol Cell. 2000;5:189-195.
40. Bousquet J, Chanez P, Lacoste YJ, et al. Eosinophilic inflammation in asthma. New Engl J Med. 1990;323:1033-1039.
41. Sur S, Gleich GJ, Swanson MC, Bartemes KR, Broide DH. Eosinophilic inflammation is associated with elevation of interleukin-5 in the airways of patients with spontaneous symptomatic asthma. J Allergy Clin Immunol. 1995;96:661-668.
42. Beghini A, Ripamonti CB, Peterlongo P, et al. RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia. Hum Mol Genet. 2000;22:2297-2304.
43. Jiang Y, Liang H, Guo W, Kottickal LV, Nagarajan L. Differential expression of a novel C-terminally truncated splice form of SMAD5 in hematopoietic stem cells and leukemia. Blood. 2000;95:3945-3950.
44. Lin PM, Liu TC, Chang JG, Chen TP, Lin SF. Aberrant TSG 101 transcripts in acute myeloid leukemia. Br J Haematol. 1998;102:753-758.
45. Legras S, Gunthert U, Stauder R, et al. A strong expression of CD44-6v correlates with shorter survival of patients with acute myeloid leukemia. Blood. 1998;91:3401-3413.
46. Veuger MJ, Honders MW, Landegent JE, Willemze R, Barge RM. High incidence of alternatively spliced forms of deoxycytidine kinase in patients with resistant acute myeloid leukemia. Blood. 2000;96:1517-1524.
47. Yang L, Embree LJ, Hickstein DD. TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins. Mol Cell Biol. 2000;20:3345-3354.