Medulloblastomas with systemic metastases: Evaluation of tumor histopathology and clinical behavior in 23 patients

Journal of Pediatric Hematology/Oncology

Volumn 25, Issue 3, 2003, Pages 198-203

  Eberhart, Charles G ^a   Cohen, Kenneth J ^b   Tihan, Tarik ^a   Goldthwaite, Patricia T ^a   Burger, Peter C ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Anaplasia; Medulloblastoma; Metastasis; PNET

Indexed keywords

ADOLESCENT; ADULT; ANAPLASTIC CARCINOMA; ARTICLE; BONE MARROW METASTASIS; BONE METASTASIS; BONE SCINTISCANNING; CANCER MORTALITY; CANCER RECURRENCE; CANCER SURVIVAL; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; DNA MICROARRAY; FEMALE; HISTOPATHOLOGY; HUMAN; LUNG METASTASIS; LYMPH NODE METASTASIS; MALE; MEDULLOBLASTOMA; METASTASIS; PRIORITY JOURNAL; REMISSION; SOFT TISSUE METASTASIS;

ADOLESCENT; ADULT; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; FEMALE; HUMANS; INFANT; MALE; MEDULLOBLASTOMA;

EID: 0037336192     PISSN: 10774114     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043426-200303000-00004     Document Type: Article

References (32)

1. Campbell AN, Chan HS, Becker LE, et al. Extracranial metastases in childhood primary intracranial tumors. A report of 21 cases and review of the literature. Cancer 1984;53:974-81.
2. Banna M, Lassman LP, Pearce GW. Radiological study of skeletal metastases from cerebellar medulloblastoma. Br J Radiol 1970;43:173-9.
3. Kessler LA, Dugan P, Concannon JP. Systemic metastases of medulloblastoma promoted by shunting. Surg Neurol 1975;3:147-52.
4. McComb JG, Davis RL, Isaacs H Jr. Extraneural metastatic medulloblastoma during childhood. Neurosurgery 1981;9:548-51.
5. Spencer CD, Weiss RB, Van Eys J, et al. Medulloblastoma metastatic to the marrow. Report of four cases and review of the literature. J Neurooncol 1984; 2:223-35.
6. Krouwer HG, Vollmerhausen J, White J, et al. Desmoplastic medulloblastoma metastatic to the pancreas: case report. Neurosurgery 1991;29:612-6.
7. Tarbell NJ, Loeffler JS, Silver B, et al. The change in patterns of relapse in medulioblastoma. Cancer 1991;68:1600-4.
8. Jamjoom ZA, Jamjoom AB, Sulaiman AH, et al. Systemic metastasis of medulloblastoma through ventriculoperitoneal shunt: report of a case and critical analysis of the literature. Surg Neurol 1993;40:403-10.
9. Sure U, Bertalanffy H, Isenmann S, et al. Secondary manifestation of medulloblastoma: metastases and local recurrences in 66 patients. Acta Neurochir 1995; 136:117-26.
10. Chang CH, Housepian EM, Herbert C Jr. An operative staging system and a megavoltage radiotherapeutic technic for cerebellar medulloblastomas. Radiology 1969;93:1351-9.
11. Eberhart CG, Kratz JE, Schuster A, et al. Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas. Brain Pathol 2002;12:36-44.
12. Eberhart CG, Kepner JL, Goldthwaite PT, et al. Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study. Cancer 2002;94: 552-60.
13. Kleinman GM, Hochberg FH, Richardson EP Jr. Systemic metastases from medulloblastoma: report of two cases and review of the literature. Cancer 1981; 48:2296-309.
14. Berry MP, Jenkin RD, Keen CW, et al. Radiation treatment for medulloblastoma. A 21-year review. J Neurosurg 1981;55:43-51.
15. Bloom HJ, Bessell EM. Medulloblastoma in adults: a review of 47 patients treated between 1952 and 1981. Int J Radiat Oncol Biol Phys 1990;18:763-72.
16. Walter AW, Mulhern RK, Gajjar A, et al. Survival and neurodevelopmental outcome of young children with medulloblastoma at St. Jude Children's Research Hospital. J Clin Oncol 1999;17:3720-8.
17. SEER Cancer Statistics Review, 1973-1998. In: National Cancer Institute, 2001.
18. Packer RJ, Goldwein J, Nicholson HS, et al. Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children's Cancer Group Study. J Clin Oncol 1999; 17: 2127-36.
19. Minn AY, Pollock BH, Garzarella L, et al. Surveillance neuroimaging to detect relapse in childhood brain tumors: a Pediatric Oncology Group study. J Clin Oncol 2001;19:4135-40.
20. Brown HG, Kepner JL, Perlman EJ, et al. "Large cell/anaplastic" medulloblastomas: a Pediatric Oncology Group Study. J Neuropathol Exp Neurol 2000;59: 857-65.
21. Giangaspero F, Rigobello L, Badiali M, et al. Large-cell medulloblastomas. A distinct variant with highly aggressive behavior. Am J Surg Pathol 1992;16: 687-93.
22. Kleihuis P, Cavenee WK. Tumors of the Nervous System. Lyon, France: IARC Press, 2000.
23. Leonard JR, Cai DX, Rivet DJ, et al. Large cell/anaplastic medulloblastomas and medullomyoblastomas: clinicopathological and genetic features. J Neurosurg 2001;95:82-8.
24. Jay V, Squire J, Bayani J, et al. Oncogene amplification in medulloblastoma: analysis of a case by comparative genomic hybridization and fluorescence in situ hybridization. Pathology 1999;31:337-44.
25. Stuart AG, Pearson AD, Emslie J, et al. Cytogenetic abnormalities in a disseminated medulloblastoma. Med Pediatr Oncol 1993;21:295-8.
26. Batra SK, McLendon RE, Koo JS, et al. Prognostic implications of chromosome 17p deletions in human medulloblastomas. J Neurooncol 1995;24:39-45.
27. Biegel JA, Janss AJ, Raffel C, et al. Prognostic significance of chromosome 17p deletions in childhood primitive neuroectodermal tumors (medulloblastomas) of the central nervous system. Clin Cancer Res 1997;3:473-8.
28. Cogen PH, Daneshvar L, Metzger AK, et al. Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis. Am J Hum Genet 1992;50: 584-9.
29. Emadian SM, McDonald JD, Gerken SC, et al. Correlation of chromosome 17p loss with clinical outcome in medulloblastoma. Clin Cancer Res 1996;2: 1559-64.
30. Scheurlen WG, Schwabe GC, Joos S, et al. Molecular analysis of childhood primitive neuroectodermal tumors defines markers associated with poor outcome. J Clin Oncol 1998;16:2478-85.
31. Reardon DA, Michalkiewicz E, Boyett JM, et al. Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. Cancer Res 1997;57:4042-7.
32. MacDonald TJ, Brown KM, LaFleur B, et al. Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nat Genet 2001;29:143-52.