Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis

Blood

Volumn 103, Issue 7, 2004, Pages 2661-2667

  Tlwari, Sanjay ^b   Felekkis, Kyriacos ^b   Moon, Eun Yi ^b   Flies, Amanda ^b   Sherr, David H ^b   Lerner, Adam ^a  

^a BOSTON MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; 8 BROMO CYCLIC AMP; ANTIPORTER; APOPTOSIS INHIBITOR; CELL PROTEIN; CILOSTAMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GUANOSINE DIPHOSPHATE; PHOSPHODIESTERASE IV INHIBITOR; PROTEIN EPAC1; RAP PROTEIN; ROLIPRAM; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CELL LINEAGE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; ENZYME INHIBITION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; T CELL LEUKEMIA; TRANSCRIPTION REGULATION;

EID: 1642296250     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-06-2154     Document Type: Article

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