Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity

Oncogene

Volumn 24, Issue 11, 2005, Pages 1924-1935

  Yang, Huiling ^a,c   Zhao, Ruiying ^a,b   Yang, Heng Yin ^a   Lee, Mong Hong ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Akt; FOXO; HER2; p27

Indexed keywords

CYCLIN D1; DNA FRAGMENT; GLUTATHIONE TRANSFERASE; LUCIFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P27; PROTEIN TYROSINE KINASE; TETRACYCLINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR FOXO4; TUBULIN; UNCLASSIFIED DRUG; AKT1 PROTEIN, HUMAN; CARRIER PROTEIN; CDKN1B PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MLLT7 PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE; ENZYME ASSAY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; MITOGENESIS; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE NEU; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REPORTER GENE; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING; ANIMAL; CELL LINE; CELL STRAIN 3T3; CELL TRANSFORMATION; DRUG ANTAGONISM; GENETICS; HUMAN; KIDNEY; METABOLISM; PROTEIN PROCESSING; PROTO ONCOGENE;

3T3 CELLS; ANIMALS; CARRIER PROTEINS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P27; GENES, ERBB-2; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; MICE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TRANSCRIPTION FACTORS;

EID: 16244415180     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208352     Document Type: Article

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