Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness

Journal of Neurochemistry

Volumn 93, Issue 1, 2005, Pages 171-185

  McKenzie, Grahame J ^a   Stevenson, Patrick ^b   Ward, George ^a   Papadia, Sofia ^b   Bading, Hilmar ^c   Chawla, Sangeeta ^d   Privalsky, Martin ^e   Hardingham, Giles E ^b  

^a Celldex Therapeutics Inc   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Calcium signalling; Calcium calmodulin dependent protein kinase; Mitogen activated protein kinases; Nuclear hormone receptors; SMRT

Indexed keywords

CALCIUM ION; GENOMIC DNA; HISTONE DEACETYLASE; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN KINASE (CALCIUM,CALMODULIN); RETINOIC ACID RECEPTOR; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOPYRIDINE; ANILINE DERIVATIVE; BICUCULLINE; CALCIUM; CALMODULIN DEPENDENT PROTEIN KINASE IV; CALMODULIN-DEPENDENT PROTEIN KINASE IV; DNA BINDING PROTEIN; ENZYME INHIBITOR; FLUO 3; GREEN FLUORESCENT PROTEIN; HORMONE; HYDROXAMIC ACID; MEMBRANE PROTEIN; NUCLEAR RECEPTOR CO REPRESSOR 2; NUCLEAR RECEPTOR CO-REPRESSOR 2; OKADAIC ACID; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN SYNTHESIS INHIBITOR; REPRESSOR PROTEIN; RETINOIC ACID; TRICHOSTATIN A; XANTHENE DERIVATIVE;

ARTICLE; CALCIUM SIGNALING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HIPPOCAMPUS; NERVE CELL CULTURE; PLASMID; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNAPSE; TRANSCRIPTION REGULATION; ANIMAL; CELL CULTURE; CELL NUCLEUS; COMPARATIVE STUDY; CYTOLOGY; DIAGNOSTIC IMAGING; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; NERVE CELL; TIME;

4-AMINOPYRIDINE; ANILINE COMPOUNDS; ANIMALS; BICUCULLINE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CELL NUCLEUS; CELLS, CULTURED; DIAGNOSTIC IMAGING; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; GABA ANTAGONISTS; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; HISTONE DEACETYLASES; HORMONES; HYDROXAMIC ACIDS; MEMBRANE PROTEINS; NEURONS; OKADAIC ACID; POTASSIUM CHANNEL BLOCKERS; PROTEIN SYNTHESIS INHIBITORS; RECEPTORS, NOTCH; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRETINOIN; XANTHENES;

EID: 16244362345     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03010.x     Document Type: Article

References (56)

1. Allman D., Punt J. A., Izon D. J., Aster J. C. and Pear W. S. (2002) An invitation to T and more: notch signaling in lymphopoiesis. Cell 109, S1-S11.
2. Anderson K. A. and Means A. R. (2002) Defective signaling in a sub-population of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV. Mol. Cell Biol. 22, 23-29.
3. Artavanis-Tsakonas S., Rand M. D. and Lake R. J. (1999) Notch signaling: cell fate control and signal integration in development. Science 284, 770-776.
4. Borodinsky L. N., Root C. M., Cronin J. A., Sann S. B., Gu X. and Spitzer N. C. (2004) Activity-dependent homeostatic specification of transmitter expression in embryonic neurons. Nature 429, 523-530.
5. Chawla S., Hardingham G. E., Quinn D. R. and Bading H. (1998) CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. Science 281, 1505-1509.
6. Chawla S., Vanhoutte P., Arnold F. J., Huang C. L. and Bading H. (2003) Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5. J. Neurochem. 85, 151-159.
7. Chen W. G., Chang Q., Lin Y, Meissner A., West A. E., Griffith E. C., Jaenisch R. and Greenberg M. E. (2003) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302, 885-889.
8. Chiang M. Y., Misner D., Kempermann G., Schikorski T., Giguere V., Sucov H. M., Gage F. H., Stevens C. F. and Evans R. M. (1998) An essential role for retinoid receptors RARβ and RXRγ in long-term potentiation and depression. Neuron 21, 1353-1361.
9. Costa R. M., Honjo T. and Silva A. J. (2003) Learning and memory deficits in Notch mutant mice. Curr. Biol. 13, 1348-1354.
10. Downes M., Ordentlich P., Kao H. Y., Alvarez J. G. and Evans R. M. (2000) Identification of a nuclear domain with deacetylase activity. Proc. Natl Acad. Sci. USA 97, 10 330-10 335.
11. Etchamendy N., Enderlin V., Marighetto A., Vouimba R. M., Pallet V., Jaffard R. and Higueret P. (2001) Alleviation of a selective age-related relational memory deficit in mice by pharmacologically induced normalization of brain retinoid signaling. J. Neurosci. 21, 6423-6429.
12. Fey E. G., Wan K. M. and Penman S. (1984) Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: three-dimensional organization and protein composition. J. Cell Biol. 98, 1973-1984.
13. Fraser J. D., Newton M. E. and Weiss A. (1992)CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. J. Exp. Med. 175, 1131-1134.
14. Goldman P. S., Tran V. K. and Goodman R. H. (1997) The multifunctional role of the co-activator CBP in transcriptional regulation. Recent Prog. Horm. Res. 240, 425-429.
15. Grozinger C. M. & Schreiber S. L. (2000) Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc. Natl Acad. Sci. USA 97, 7835-7840.
16. Hardingham G. E. and Bading H. (2003) The yin and yang of NMDA receptor signalling. Trends Neurosci. 26, 81-89.
17. Hardingham G. E., Arnold F. J. and Bading H. (2001a) A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication. Nat. Neurosci. 4, 565-566.
18. Hardingham G. E., Arnold F. J. and Bading H. (2001b) Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. Nat. Neurosci. 4, 261-267.
19. Hardingham G. E., Fukunaga Y. and Bading H. (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat. Neurosci. 5, 405-414.
20. Hermanson O., Jepsen K. and Rosenfeld M. G. (2002) N-CoR controls differentiation of neural stem cells into astrocytes. Nature 419, 934-939.
21. Heuer H. and Mason C. A. (2003) Thyroid hormone induces cerebellar Purkinje cell dendritic development via the thyroid hormone receptor α1. J. Neurosci. 23, 10 604-10 612.
22. Hong S. H. and Privalsky M. L. (2000) The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export. Mol. Cell Biol. 20, 6612-6625.
23. Hook S. S. and Means A. R. (2001) Ca2+/CaM-dependent kinases: from activation to function. Annu. Rev. Pharm. Tox. 41, 471-505.
24. Hosoda R., Nakayama K., Kato-Negishi M., Kawahara M., Muramoto K. and Kuroda Y. (2003) Thyroid hormone enhances the formation of synapses between cultured neurons of rat cerebral cortex. Cell Mol. Neurobiol. 23, 895-906.
25. Hu X. and Lazar M. A. (2000) Transcriptional repression by nuclear hormone receptors. Trends Endocrinol. Metab. 11, 6-10.
26. Jang M. K., Goo Y. H., Sohn Y. C., Kim Y. S., Lee S. K., Kang H., Cheong J. and Lee J. W. (2001) Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-κB transactivation via phosphorylation of the p65 subunit. J. Biol. Chem. 276, 20 005-20 010.
27. Jarriault S., Brou C., Logeat F., Schroeter E. H., Kopan R. and Israel A. (1995) Signalling downstream of activated mammalian Notch. Nature 377, 355-358.
28. Jepsen K. and Rosenfeld M. G. (2002) Biological roles and mechanistic actions of co-repressor complexes. J. Cell Sci. 115, 689-698.
29. Kane L. P., Andres P. G., Howland K. C., Abbas A. K. and Weiss A. (2001) Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines. Nat. Immunol. 2, 37-44.
30. Kao H. Y., Ordentlich P., Koyano-Nakagawa N., Tang Z., Downes M., Kintner C. R., Evans R. M. and Kadesch T. (1998) A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev. 12, 2269-2277.
31. Kao H. Y., Downes M., Ordentlich P. and Evans R. M. (2000) Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 14, 55-66.
32. Konig S. and Moura Neto V. (2002) Thyroid hormone actions on neural cells. Cell Mol. Neurobiol. 22, 517-544.
33. Kuno-Murata M., Koibuchi N., Fukuda H., Murata M. and Chin W. W. (2000) Augmentation of thyroid hormone receptor-mediated transcription by Ca2+/calmodulin-dependent protein kinase type IV. Endocrinology 141, 2275-2278.
34. Lee J. W., Jung D. J., Lee Y. C., Cheong J. H. and Lee S. K. (2000) SMRT as a novel transcriptional corepressor molecule of AP-1, NF-kB and SRF. J. Biol. Chem. 275, 12 470-12 474.
35. Lee J. W., Lee Y. C., Na S. Y., Jung D. J. and Lee S. K. (2001) Transcriptional coregulators of the nuclear receptor superfamily: coactivators and corepressors. Cell Mol. Life Sci. 58, 289-297.
36. Lewis R. S. (2001) Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 19, 497-521.
37. Maden M. (2001) Role and distribution of retinoic acid during CNS development. Int. Rev. Cytol. 209, 1-77.
38. McKenzie G. J., Young L. L., Briend E., Lamb J. R., Dallman M. J. and Champion B. R. (2003) Notch signalling in the regulation of peripheral T-cell function. Semin. Cell Dev. Biol. 14, 127-134.
39. McKinsey T. A., Zhang C. L., Lu J. and Olson E. N. (2000) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408, 106-111.
40. Milner B., Squire L. R. and Kandel E. R. (1998) Cognitive neuroscience and the study of memory. Neuron 20, 445-468.
41. Miska E. A., Karlsson C., Langley E., Nielsen S. J., Pines J. and Kouzarides T. (1999) HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J. 18, 5099-5107.
42. Miska E. A., Langley E., Wolf D., Karlsson C., Pines J. and Kouzarides T. (2001) Differential localization of HDAC4 orchestrates muscle differentiation. Nucl. Acids Res. 29, 3439-3447.
43. Mumm J. S. and Kopan R. (2000) Notch signaling: from the outside in. Dev. Biol. 228, 151-165.
44. Oswald F., Tauber B., Dobner T., Bourteele S., Kostezka U., Adler G., Liptay S. and Schmid R. M. (2001) p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol. Cell Biol. 21, 7761-7774.
45. Redmond L., Oh S. R., Hicks C., Weinmaster G. and Ghosh A. (2000) Nuclear Notch1 signaling and the regulation of dendritic development. Nat. Neurosci. 3, 30-40.
46. Sestan N., Artavanis-Tsakonas S. and Rakic P. (1999) Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science 286, 741-746.
47. Sohn Y. C., Kim S. W., Lee S., Kong Y. Y., Na D. S., Lee S. K. and Lee J. W. (2003) Dynamic inhibition of nuclear receptor activation by corepressor binding. Mol. Endocrinol. 17, 366-372.
48. Spitzer N. C., Root C. M. and Borodinsky L. N. (2004) Orchestrating neuronal differentiation: patterns of Ca(2+) spikes specify transmitter choice. Trends Neurosci. 27, 415-421.
49. Stephensen C. B. (2001) Vitamin A, infection, and immune function. Annu. Rev. Nutr. 21, 167-192.
50. Vara H., Martinez B., Santos A. and Colino A. (2002) Thyroid hormone regulates neurotransmitter release in neonatal rat hippocampus. Neuroscience 110, 19-28.
51. Wang J., Campos B., Jamieson G. A., Kaetzel M. A. and Dedman J. R. (1995) Functional elimination of calmodulin within the nucleus by targeted expression of an inhibitor peptide. J. Biol. Chem. 270, 30 245-30 248.
52. West A. E., Chen W. G., Dalva M. B., Dolmetsch R. E., Kornhauser J. M., Shaywitz A. J., Takasu M. A., Tao X. and Greenberg M. E. (2001) Calcium regulation of neuronal gene expression. Proc. Natl Acad. Sci. USA 98, 11 024-11 031.
53. Wong R. O. and Ghosh A. (2002) Activity-dependent regulation of dendritic growth and patterning. Nat. Rev. Neurosci. 3, 803-812.
54. Wu X., Li H., Park E. J. and Chen J. D. (2001) SMRTE inhibits MEF2C transcriptional activation by targeting HDAC4 and 5 to nuclear domains. J. Biol. Chem. 276, 24 177-24 185.
55. Zhou S. and Hayward S. D. (2001) Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. Mol. Cell Biol. 21, 6222-6232.
56. Zhou S., Fujimuro M., Hsieh J. J., Chen L., Miyamoto A., Weinmaster G. and Hayward S. D. (2000) SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function. Mol. Cell Biol. 20, 2400-2410.