Leukemia inhibitory factor by systemic administration rescues spinal motor neurons in the SOD1 G93A murine model of familial amyotrophic lateral sclerosis

Brain Research

Volumn 922, Issue 1, 2001, Pages 144-147

  Azari, Michael F ^a   Galle, Adam ^a   Lopes, Elizabeth C ^a   Kurek, John ^b   Cheema, Surindar S ^a  

^a MONASH UNIVERSITY   (Australia)

^b Zenyth Therapeutics Limited Australia   (Australia)

Author keywords

Leukemia inhibitory; Neuroprotective; SOD1 G93A transgenic mice; Spinal motonueron

Indexed keywords

LEUKEMIA INHIBITORY FACTOR; RECOMBINANT PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FAMILIAL DISEASE; FEMALE; LUMBAR VERTEBRA; MISSENSE MUTATION; MOUSE; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD MOTONEURON; TREATMENT OUTCOME;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CACHEXIA; CELL COUNT; CELL SURVIVAL; GROWTH INHIBITORS; HUMANS; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-6; LEUKEMIA INHIBITORY FACTOR; LYMPHOKINES; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; PILOT PROJECTS; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 0035856861     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)03156-0     Document Type: Article

References (24)

1. A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis
2. A controlled trial of recombinant methionyl human BDNF in ALS
3. Leukaemia inhibitory factor rescues motoneurones from axotomy-induced cell death
4. Retrograde axonal transport of LIF is increased by peripheral nerve injury: Correlation with increased LIF expression in distal nerve
5. A phase I trial of AM424 (rhLIF) administered to oncology patients pre and post chemotherapy
6. Transgenic animal models of familial amyotrophic lateral sclerosis
7. Members of several gene families influence survival of rat motoneurons in vitro and in vivo
8. Neuroprotective effect of cholinergic differentiation factor/leukemia inhibitory factor on wobbler murine motor neuron disease
9. Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease
10. Histometric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease
11. Essential function of LIF receptor in motor neurons
12. There is no loss of motor neurons in the rat spinal cord during postnatal maturation
13. A potential role for the p75 low affinity neurotrophin receptor in spinal motor neuron degeneration in murine and human amyotrophic lateral sclerosis
14. Recombinant human leukemia inhibitory factor induces acute phase proteins and raises the blood platelet counts in nonhuman primates
15. Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF
16. Saturable entry of leukemia inhibitory factor from blood to the central nervous system
17. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
18. Expression of leukemia inhibitory factor receptor mRNA in sensory dorsal root ganglion and spinal motor neurons of the neonatal rat
19. Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section
20. Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy
21. Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy
22. Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions
23. Localization of mRNA for leukemia inhibitory factor receptor in the adult rat brain
24. In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons