Cytochromes P450: Novel drug targets in the war against multidrug-resistant Mycobacterium tuberculosis

Biochemical Society Transactions

Volumn 31, Issue 3, 2003, Pages 625-630

  Munro, A W ^a   McLean, K J ^a   Marshall, K R ^a   Warman, A J ^a   Lewis, G ^a   Roitel, O ^a   Sutcliffe, M J ^a   Kemp, C A ^a   Modi, S ^b   Scrutton, N S ^a   Leys, D ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Cytochrome P450 CYP121; Multidrug resistance; Mycobacteria; Tuberculosis

Indexed keywords

ANTIMYCOBACTERIAL AGENT; BACTERIAL ENZYME; CLOTRIMAZOLE; CYTOCHROME P450; CYTOCHROME P450 CYP121; ECONAZOLE; ISONIAZID; PYRAZINAMIDE; RIFAMPICIN; STEROL 14ALPHA DEMETHYLASE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

BACTERIAL GENOME; CONFERENCE PAPER; DRUG BINDING SITE; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME STRUCTURE; GENE MUTATION; MULTIDRUG RESISTANCE; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; TUBERCULOSIS;

ANTITUBERCULAR AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG RESISTANCE, MULTIPLE; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PROTEIN CONFORMATION;

BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; PROKARYOTA;

EID: 10744226049     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0310625     Document Type: Conference Paper

References (31)

1. Young, D.B. and Cole, S.T. (1993). J. Bacteriol. 175, 1-6
2. Bloom, B.R. and Murray, C.J.L. (1992). Science 257, 1055-1063
3. World Health Organization report (2002) Global tuberculosis control, surveillance, planning, financing, http://www.who.int/gtb/publications/globrep02/downloadpage.html
4. Mdluli, K., Slayden, R.A., Zhu, Y., Ramaswamy, S., Pan, X., Mead, D., Crane, D.D., Musser, J.M. and Barry, III, C.E. (1998) Science 280, 1607-1610
5. Rozwarski, D.A., Grant, G.A., Barton, D.H.R., Jacobs, W.R. and Sacchetini, J.C. (1998) Science 267, 1638-1641
6. Cole, S.T. (1994) Trends Microbiol. 2, 411-415
7. Heym, B., Alzari, P., Honore, N. and Cole, S.T. (1995) Mol. Microbiol. 15, 235-245
8. Raynaud, C., Laneelle, M.A., Senaratne, R.H., Draper, P., Laneelle, G. and Daffe, M. (1999) Microbiology 145, 1359-1367
9. Honore, N. and Cole, S.T. (1994) Antimicrob. Agents Chemother. 38, 238-242
10. Ramaswamy, S.V., Amin, A.G., Gostel, S., Stager, C.E., Dous, J., Sahly, H.E., Moghazed, S.L., Kreiswirth, B.N. and Musseer, J.M. (2000) Antimicrob Agents Chemother. 44, 326-336
11. Vanelli, T.A., Dykman, A. and Ortiz de Montellano, P.R. (2002) J. Biol. Chem. 277, 12824-12829
12. Baulard, A.R., Betts, J.C., Engohang-Ndong, J., Quan, S., McAdam, R.A., Brennan, P.J., Locht, C. and Besra, G.S. (2000) J. Biol. Chem. 275, 28326-28331
13. Larsen, M.H., Vilcheze, C., Kremer, L., Besra, G.S., Parsons, L., Salfinger, M., Heifets, L., Hazbon, M.H., Alland, D., Sacchettini, J.C. and Jacobs, W.R. (2002) Mol. Microbiol. 46, 453-466
14. Kremer, L. and Besra, G.S. (2002) Expert Opin. Invest. Drugs 11, 1033-1049
15. Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S.V., Eiglmeier, K., Gas, S., Barry, C.E. et al. (1998) Nature (London) 393, 537-544
16. Bentley, S.D., Chater, K.F., Cerdeno-Tarraga, A.M., Challis, G.L., Thomson, N.R., James, K.D., Harris, D.E., Quail, M.A., Kieser, H., Harper, D. et al. (2002) Nature (London) 411, 141-147
17. Guengerich, F.P. (2001) Chem. Res. Toxicol. 14, 611-650
18. Munro, A.W. and Lindsay, J.G. (1996) Mol. Microbiol. 20, 1115-1125
19. Sligar, S.G. and Gunsalus, I.C. (1976) Proc. Natl. Acad. Sci. U.S.A. 73, 1078-1082
20. Andersen, J.F., Tatsuta, K., Gunji, H., Ishiyama, T. and Hutchinson, C.R. (1993) Biochemistry 32, 1905-1913
21. Lee, D.S., Park, S.Y., Yamane, K., Obayashi, E., Hori, H. and Shiro Y. (2001) Biochemistry 40, 2669-2677
22. Liu, J., Barry, C.E., Besra, G.S. and Nikaido, H. (1996) J. Biol. Chem. 271, 29545-29551
23. Cole, S.T., Eiglmeier, K., Parkhill, J., James, K.D., Thomson, N.R., Wheeler, P.R., Honore, N., Garnier, T., Churcher, C., Harris, D. et al. Nature (London) 409, 1007-1011
24. Yoshida, Y., Noshiro, M., Aoyama, Y., Kawamoto, T., Horiuchi, T. and Gotoh, O. (1997) J. Biochem. (Tokyo) 122, 1122-1128
25. Bellamine, A., Mangla, A.T., Nes, W.D. and Waterman, M.R. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 8937-8942
26. Podust, L.M., Poulos, T.L. and Waterman, M.R. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 3068-3073
27. McLean, K.J., Marshall, K.R., Richmond, A., Hunter, I.S., Fowler, K., Kieser, T., Gurcha, S.S., Besra, G.S. and Munro, A.W. (2002) Microbiology 148, 2937-2949
28. Leys, D., Mowat, C.G., McLean, K.J., Richmond, A., Chapman, S.K., Walkinshaw, M.D. and Munro, A.W. (2003) J. Biol. Chem. 278, 5141-5147
29. McLean, K.J., Cheesman, M.R., Rivers, S.L., Richmond, A., Leys, D., Chapman, S.K., Reid, G.A., Price, N.C., Kelly, S.M., Clarkson, J. et al (2002) J. Inorg. Biochem. 91, 527-541
30. Bossi, R.T., Aliverti, A., Raimondi, D., Fischer, F., Zanetti, G., Ferrari, D., Tahallah, N., Maier, C.S., Heck, A.J.R., Rizzi, M. and Mattevi, A. (2002) Biochemistry 41, 8807-8818
31. Gutierrez, A., Paine, M., Wolf, C.R., Scrutton, N.S. and Roberts, G.C.K. (2002) Biochemistry 41, 4626-4637