Molecular physiology of intestinal Na+/H+ exchange

Annual Review of Physiology

Volumn 67, Issue , 2005, Pages 411-443

  Zachos, Nicholas C ^a   Tse, Ming ^a   Donowitz, Mark ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brush border; Na+ absorption; NHE2; NHE3; Trafficking

Indexed keywords

ISOPROTEIN; REGULATOR PROTEIN; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 2; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG;

BASOLATERAL MEMBRANE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELLULAR DISTRIBUTION; COLON ABSORPTION; DIARRHEA; ENDOSOME; HUMAN; INTESTINE ABSORPTION; MULTIGENE FAMILY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTON SODIUM EXCHANGE; REVIEW; SODIUM ABSORPTION; WATER ABSORPTION;

ANIMALS; HUMANS; INTESTINES; MULTIGENE FAMILY; SODIUM-HYDROGEN ANTIPORTER;

EID: 15744368985     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.67.031103.153004     Document Type: Review

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72. + exchange. Am. J. Physiol. Cell Physiol. 274:C1261-72
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109. Peng Y, Amemiya M, Yang X, Fan L, Moe OW, et al. 2001. ET(B) receptor activation causes exocytic insertion of NHE3 in OKP cells. Am. J. Physiol. Renal Physiol. 280:F34-42
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112. + exchanger using chymotryptic cleavage. Am. J. Physiol. Cell Physiol. 75:C431-39
113. 2B- adrenergic receptors for inhibiting the Na/H exchanger, NHE1. J. Biol. Chem. 278:15128-35
114. + exchanger 3. J. Biol. Chem. 276:31296-304
115. + exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors. J. Biol. Chem. 270:13716-25
116. + exchanger. J. Biol. Chem. 277:36085-91
117. + exchanger NHE3 isoform. J. Biol. Chem. 271:3590-99
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119. + exchangers NHE1 and NHE2. Biochemistry 42:1086-94
120. 2+ regulation-defective. J. Biol. Chem. 269:13710-15
121. + exchanger NHE1 through sequence-specific interaction. Biochemistry 36:12854-61
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123. + exchange requires phosphatidylinositol 4,5-bisphosphate. J. Cell Biol. 150:213-24
124. Lin X, Barber DL. 1996. A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. Proc. Natl. Acad. Sci. USA 93:12631-36
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126. + exchanger. J. Biol. Chem. 277:43771-77
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130. + exchanger type-1. FEBS Lett. 507:331-35
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132. + exchange. J. Biol. Chem. 276:15794-800
133. + exchanger interacts with mammalian heat shock protein. Biochemistry 34:10412-20
134. + exchanger. J. Biol. Chem. 277:36085-91
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136. + exchanger isoform NHE3 in the proximal tubule. J. Biol. Chem. 274:17518-24
137. + exchanger isoform NHE3 and dipeptidyl peptidase IV in the renal proximal tubule. J. Biol. Chem. 276:46671-77
138. + exchanger NHE3 by dopamine (DA): direction interaction of PP2A with NHE3. J. Am. Soc. Neph. 12:8A
139. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, et al. 2003. PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. Kidney Int. 64:1733-45
140. + exchanger 3 (NHE3) and this interaction is necessary for NHE3 activity. Gastroenterology 126:A43
141. Donowitz M, Kambadur R, Zizak M, Nath S, Akhter S, Tse M. 1997. NHE3 is a calmodulin binding protein: Calmodulin inhibits NHE3 by binding to the C-terminal 76 amino acids of NHE3. Gastroenterology 138:A360
142. + exchanger recruits ERM proteins to regulate Akt-dependent cell survival. J. Biol. Chem. 279:26280-86
143. + exchanger isoform NHE3 is regulated by the actin cytoskeleton. J. Biol. Chem. 274:29843-49
144. + exchanger NHE3. Role of myosin light chain phosphorylation. J. Biol. Chem. 275:28599-606
145. + exchanger NHE3. J. Biol. Chem. 276:40761-68
146. Sabolic I, Herak-Kramberger CM, Ljubojevic M, Biemesderfer D, Brown D. 2002. NHE3 and NHERF are targeted to the basolateral membrane in proximal tubules of colchicines-treated rats. Kidney Int. 61:1351-64
147. + exchanger, by clostridium difficile toxin B. J. Gen. Physiol. 123:491-504
148. Cha B, Kenworthy A, Murtazina R, Donowitz M. 2004. The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain protein NheRF1/2 but is dependent on an intact actin cytoskeleton as determined by FRAP. J. Cell Sci. 117:3353-65
149. + antiporter, glycoprotein of 110 kD. Science 247:723-26
150. + exchanger isoform 3 stably expressed in fibroblasts by fibroblast growth factor and phorbol esters is not through changes in phosphorylation of the exchanger. J. Biol. Chem. 272:18473-80
151. Moe OW, Amemiya M, Yamaji Y. 1995. Activation of protein kinase A acutely inhibits and phosphorylates Na/H exchanger NHE-3. J. Clin. Invest. 96:2187-94
152. + exchanger NHE3 activity by cAMP-dependent protein kinase. Phosphorylation-dependent and - independent mechanisms. J. Biol. Chem. 272:28672-79
153. Zhao H, Wiederkehr MR, Fan L, Collazo RL, Crowder LA, Moe OW. 1999. Acute inhibition of Na/H exchanger NHE-3 by cAMP. Role of protein kinase A and NHE-3 phosphoserines 552 and 605. J. Biol. Chem. 274:3978-87
154. + exchanger isoform-1. J. Biol. Chem. 274:20206-14
155. Aitken A, Baxter H, Dubois T, Clokie S, Mackie S, et al. 2002. Specificity of 14-3-3 isoform dimer interactions and phosphorylation. Biochem. Soc. Trans. 30:351-60
156. + exchanger (NHE3) is dependent on the presence but not the phosphorylation of NHERF. J. Biol. Chem. 274:24753-58
157. Wiederkehr MR, Zhao H, Moe OW. 1999. Acute regulation of Na/H exchanger NHE3 activity by protein kinase C: role of NHE3 phosphorylation. Am. J. Physiol. Cell Physiol. 276:C1205-17
158. Muller YL, Collins JF, Bai L, Xu H, Ghishan FK. 1998. Molecular cloning and characterization of the rat NHE-2 gene promoter. Biochim. Biophys. Acta 1442:314-19
159. + exchanger NHE3 gene. J. Biol. Chem. 271:10551-59
160. + exchanger NHE3 promoter. Am. J. Physiol. Gastrointest. Liver Physiol. 282:0491-500
161. + exchanger activity is upregulated by bowel resection in the weanling rat. Pediatr. Res. 33:215-20
162. + exchanger isoforms after enterectomy. J. Surg. Res. 86:192-97
163. Musch MW, Bookstein C, Xie Y, Sellin JH, Chang EB. 2001. SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestine C2/bbe cells. Am. J. Physiol. Gastrointest. Liver Physiol. 280:G687-93
164. + exchanger isoform. J. Biol. Chem. 263:206-11
165. + exchange expression and activity in region- and tissue-specific manner. Am. J. Physiol. Cell Physiol. 267:C796-803
166. + absorption in rats by increasing NHE3 expression of the proximal colon. Am. J. Physiol. Cell Physiol. 274:C586-94
167. + exchanger isoform 3 revisited. The roles of SGK1 and NHERF2. J. Biol. Chem. 277:7676-83
168. Charney AN, Dagher PC. 1996. Acid-base effects on colonic electrolyte transport revisited. Gastroenterology 111:1358-68
169. Charney AN, Feldman GM. 1984. Systemic acid-base disorders and intestinal electrolyte transport. Am. J. Physiol. Gastrointest. Liver Physiol. 247:G1-12
170. Lucioni A, Womack C, Musch MW, Rocha FL, Bookstein C, Chang EB. 2002. Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function. Am. J. Physiol. Gastrointest. Liver Physiol. 283:G51-56
171. Sandle GI, Higgs N, Crowe P, Marsh MN, Venkatesan S, Peters TJ. 1990. Cellular basis for defective electrolyte transport in inflamed human colon. Gastroenterology 99:97-105
172. Barmeyer C, Harren M, Schmilz H, Heinzel-Pleines U, Mankertz J, et al. 2004. Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 286:G244-52
173. Ameen NA, Salas PJ. 2000. Microvillus inclusion disease: a genetic defect affecting apical membrane protein traffic in intestinal epithelium. Traffic 1:76-83
174. Muller T, Wijmenga C, Phillips AD, Janecke A, Houwen RH, et al. 2000. Congenital sodium diarrhea is an autosomal recessive disorder of sodium/proton exchange but unrelated to known candidate genes. Gastroenterology 119:1506-13