Regulation of NHE3 by nitric oxide in Caco-2 cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 283, Issue 3 46-3, 2002, Pages

  Gill, Ravinder K ^a,b   Saksena, Seema ^a,b   Syed, Irfan Ali ^a,b   Tyagi, Sangeeta ^a,b   Alrefai, Waddah A ^a,b   Malakooti, Jaleh ^a,b   Ramaswamy, Krishnamurthy ^a,b   Dudeja, Pradeep K ^a,b  

^a JESSE BROWN VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

cGMP; S nitroso N acetylpenicillamine; Sodium hydrogen exchanger

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 5 (N ETHYL N ISOPROPYL)AMILORIDE; 6 ANILINO 5,8 QUINOLINEQUINONE; 8 BROMO CYCLIC GMP; CALPHOSTIN C; CHELERYTHRINE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; KT 5823; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ARTICLE; CELL LEVEL; CELL STRAIN CACO 2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; INCUBATION TIME; INHIBITION KINETICS; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SODIUM TRANSPORT; TRANSPORT KINETICS;

EID: 0036721495     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00294.2001     Document Type: Article

References (61)

1. Nitric oxide inhibits potassium transport in the rat distal colon
2. A critical role for nitric oxide in intestinal barrier function and dysfunction
3. + exchanger isoform NHE3 by PKC-a in Caco-2 cells
4. + exchanger isoforms, NHE2 and NHE 3, in C2bbe cells
5. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
6. Nitric oxide-dependent and -independent effects on human platelets treated with peroxynitrite
7. Activation of a cytosolic ADP-ribosyltransferase by nitric oxide-generating agents
8. 1 angiotensin II receptor that is present in proximal tubule epithelium
9. Involvement of endogenous nitric oxide in the regulation of rat intestinal motility in vivo
10. + antiporter in vascular smooth muscle cells in culture
11. E3KARP (NHE3 kinase A anchoring protein) is necessary for cGMP regulation of NHE3: Demonstration of a plasma membrane signaling complex containing NHE3, E3KARP, and cGMP kinase II
12. Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP
13. Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease
14. + exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA
15. Plasma nitrate concentration in infective gastroenteritis and inflammatory bowel disease
16. EDRF from rat intestine and skeletal muscle venules causes dilation of arterioles
17. - transport by heat-stable enterotoxin: Activation of cAMP-dependent protein kinase by cGMP
18. Nitric oxide inhibits ADH-stimulated osmotic water permeability in cortical collecting ducts
19. Nitric oxide inhibits sodium/hydrogen exchange activity in the thick ascending limb
20. Interferon-γ and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells
21. 15N]nitrate in biological fluids
22. Regulation of electrolyte transport by nitric oxide in the mouse cecum
23. NHE-2 and NHE-3 are human and rabbit intestinal brush-border proteins
24. Inhibition of guanylate cyclase stimulation by NO and bovine arterial relaxation to peroxynitrite and H 202
25. Nitric oxide as a modulator of intestinal water and electrolyte transport
26. + exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchanger
27. Nitric oxide and inflammatory bowel disease: Evidence for local intestinal production in children with active colonic disease
28. Production and functional roles of nitric oxide in the proximal tubule
29. + antiport activity in rat alveolar epithelial cells
30. Nitric oxide-donating compounds stimulate electrolyte transport in the guinea pig intestine in vitro
31. Macrophage oxidation of L-arginine to nitrite and nitrate: Nitric oxide is an intermediate
32. Nitric oxide, cGMP, and hormone regulation of active sodium transport
33. + exchangers NHE2 and NHE3 in intestinal epithelial cell line C2/bbe
34. Amelioration of chronic ileitis by nitric oxide synthase inhibition
35. Nitric oxide: Physiology, pathophysiology, and pharmacology
36. SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells
37. Nitric oxide as a secretory product of mammalian cells
38. Nitric oxide synthase distribution in the rat intestine: A histochemical analysis
39. Nitric oxide donor-induced apoptosis in smooth muscle cells is modulated by protein kinase C and protein kinase A
40. Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells
41. + exchange in human normal and cystic fibrosis ciliated airway epithelium
42. The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation
43. Endogenous nitric oxide inhibits chloride transport in the thick ascending limb
44. Potential role of nitric oxide in a model of chronic colitis in rhesus macaques
45. + exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells
46. Nitric oxide stimulates guanylate cyclase and regulates sodium transport in rabbit proximal tubule
47. - exchange process in Caco2 cells by nitric oxide
48. Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers
49. Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
50. +-ATPase by interferon-γ down-regulates intestinal epithelial transport and barrier function
51. Evidence of in vivo peroxynitrite formation in patients with colorectal carcinoma, higher plasma nitrate/nitrite levels, and lower protection against oxygen free radicals
52. Nitric oxide synthase induction and intestinal epithelial cell viability in rats
53. The involvement of protein kinase C in nitric oxide-induced damage to rat isolated colonic mucosal cells
54. + exchange across human colonic basolateral plasma membranes purified from organ donor colons
55. Signalling by cGMP-dependent protein kinases
56. Nitric oxide in mucosal defense: A little goes a long way
57. L-Arginine in low concentration improves rat intestinal water and sodium absorption from oral rehydration solutions
58. Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport
59. Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon
60. Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats
61. Regulation of epithelial brush border NHE3 expressed in fibroblasts by fibroblast growth factor and phorbol esters is not through changes in phosphorylation of the exchanger