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Volumn 164, Issue 2, 2004, Pages 557-565

Up-Regulation of the Redox Mediators Thioredoxin and Apurinic/Apyrimidinic Excision (APE)/Ref-1 in Hypoxic Microregions of Invasive Cervical Carcinomas, Mapped Using Multispectral, Wide-Field Fluorescence Image Analysis

Author keywords

[No Author keywords available]

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE IX; REDOX EFFECTOR FACTOR 1; THIOREDOXIN; UNCLASSIFIED DRUG; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; TUMOR MARKER;

EID: 1542349927     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63145-8     Document Type: Article
Times cited : (46)

References (50)
  • 1
    • 0035029131 scopus 로고    scopus 로고
    • Properties and biological activities of thioredoxins
    • Powis G, Montfort WR: Properties and biological activities of thioredoxins. Annu Rev Pharmacol Toxicol 2001, 41:261-295
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 261-295
    • Powis, G.1    Montfort, W.R.2
  • 2
    • 0033301995 scopus 로고    scopus 로고
    • From cytoprotection to tumor suppression: The multifactorial role of peroxiredoxins
    • Butterfield LH, Merino A, Golub SH, Shau H: From cytoprotection to tumor suppression: the multifactorial role of peroxiredoxins. Antioxid Redox Signal 1999, 1:385-402
    • (1999) Antioxid Redox Signal , vol.1 , pp. 385-402
    • Butterfield, L.H.1    Merino, A.2    Golub, S.H.3    Shau, H.4
  • 4
    • 0034652113 scopus 로고    scopus 로고
    • Thioredoxin reductase
    • Mustacich D, Powis G: Thioredoxin reductase. Biochem J 2000, 346:1-8
    • (2000) Biochem J , vol.346 , pp. 1-8
    • Mustacich, D.1    Powis, G.2
  • 5
    • 0034534165 scopus 로고    scopus 로고
    • Antioxidant function of thioredoxin and glutaredoxin systems
    • Holmgren A: Antioxidant function of thioredoxin and glutaredoxin systems. Antioxid Redox Signal 2000, 2:811-820
    • (2000) Antioxid Redox Signal , vol.2 , pp. 811-820
    • Holmgren, A.1
  • 6
    • 0033775891 scopus 로고    scopus 로고
    • Physiological functions of thioredoxin and thioredoxin reductase
    • Arner ES, Holmgren A: Physiological functions of thioredoxin and thioredoxin reductase. Eur J Biochem 2000, 267:6102-6109
    • (2000) Eur J Biochem , vol.267 , pp. 6102-6109
    • Arner, E.S.1    Holmgren, A.2
  • 9
    • 0036735392 scopus 로고    scopus 로고
    • The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis
    • Welsh SJ, Bellamy WT, Briehl MM, Powis G: The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. Cancer Res 2002, 62:5089-5095
    • (2002) Cancer Res , vol.62 , pp. 5089-5095
    • Welsh, S.J.1    Bellamy, W.T.2    Briehl, M.M.3    Powis, G.4
  • 11
    • 0032188756 scopus 로고    scopus 로고
    • Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation
    • Grosch S, Fritz G, Kaina B: Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation. Cancer Res 1998, 58:4410-4416
    • (1998) Cancer Res , vol.58 , pp. 4410-4416
    • Grosch, S.1    Fritz, G.2    Kaina, B.3
  • 12
    • 0035879047 scopus 로고    scopus 로고
    • Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation
    • Hsieh MM, Hegde V, Kelley MR, Deutsch WA: Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation. Nucleic Acids Res 2001, 29:3116-3122
    • (2001) Nucleic Acids Res , vol.29 , pp. 3116-3122
    • Hsieh, M.M.1    Hegde, V.2    Kelley, M.R.3    Deutsch, W.A.4
  • 14
    • 0036718792 scopus 로고    scopus 로고
    • The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress
    • Silber JR, Bobola MS, Blank A, Schoeler KD, Haroldson PD, Huynh MB, Kolstoe DD: The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress. Clin Cancer Res 2002, 8:3008-3018
    • (2002) Clin Cancer Res , vol.8 , pp. 3008-3018
    • Silber, J.R.1    Bobola, M.S.2    Blank, A.3    Schoeler, K.D.4    Haroldson, P.D.5    Huynh, M.B.6    Kolstoe, D.D.7
  • 16
    • 0035490399 scopus 로고    scopus 로고
    • DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1alpha and prognostic significance
    • Schindl M, Oberhuber G, Pichlbauer EG, Obermair A, Birner P, Kelley MR: DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance. Int J Oncol 2001, 19:799-802
    • (2001) Int J Oncol , vol.19 , pp. 799-802
    • Schindl, M.1    Oberhuber, G.2    Pichlbauer, E.G.3    Obermair, A.4    Birner, P.5    Kelley, M.R.6
  • 19
    • 0035176178 scopus 로고    scopus 로고
    • Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas
    • Bobola MS, Blank A, Berger MS, Stevens BA, Silber JR: Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas. Clin Cancer Res 2001, 7:3510-3518
    • (2001) Clin Cancer Res , vol.7 , pp. 3510-3518
    • Bobola, M.S.1    Blank, A.2    Berger, M.S.3    Stevens, B.A.4    Silber, J.R.5
  • 23
    • 0033961301 scopus 로고    scopus 로고
    • Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers
    • Moore DH, Michael H, Tritt R, Parsons SH, Kelley MR: Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers. Clin Cancer Res 2000, 6:602-609
    • (2000) Clin Cancer Res , vol.6 , pp. 602-609
    • Moore, D.H.1    Michael, H.2    Tritt, R.3    Parsons, S.H.4    Kelley, M.R.5
  • 25
    • 0038523737 scopus 로고    scopus 로고
    • Tumor hypoxia at the micro-regional level: Clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers
    • Bussink J, Kaanders JH, van der Kogel AJ: Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers. Radiother Oncol 2003, 67:3-15
    • (2003) Radiother Oncol , vol.67 , pp. 3-15
    • Bussink, J.1    Kaanders, J.H.2    Van Der Kogel, A.J.3
  • 26
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL: Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002, 2:38-47
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 27
    • 0034989311 scopus 로고    scopus 로고
    • Biological consequences of tumor hypoxia
    • Hockel M, Vaupel P: Biological consequences of tumor hypoxia. Semin Oncol 2001, 28:36-41
    • (2001) Semin Oncol , vol.28 , pp. 36-41
    • Hockel, M.1    Vaupel, P.2
  • 29
    • 0036467638 scopus 로고    scopus 로고
    • Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
    • Fyles A, Milosevic M, Hedley D, Pintilie M, Levin W, Manchul L, Hill RP: Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol 2002, 20:680-687
    • (2002) J Clin Oncol , vol.20 , pp. 680-687
    • Fyles, A.1    Milosevic, M.2    Hedley, D.3    Pintilie, M.4    Levin, W.5    Manchul, L.6    Hill, R.P.7
  • 30
    • 0035417889 scopus 로고    scopus 로고
    • Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements
    • Milosevic M, Fyles A, Hedley D, Pintilie M, Levin W, Manchul L, Hill R: Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements. Cancer Res 2001, 61:6400-6405
    • (2001) Cancer Res , vol.61 , pp. 6400-6405
    • Milosevic, M.1    Fyles, A.2    Hedley, D.3    Pintilie, M.4    Levin, W.5    Manchul, L.6    Hill, R.7
  • 31
    • 0033560677 scopus 로고    scopus 로고
    • Improved treatment for cervical cancer-concurrent chemotherapy and radiotherapy
    • Thomas GM: Improved treatment for cervical cancer-concurrent chemotherapy and radiotherapy. N Engl J Med 1999, 340:1198-1200
    • (1999) N Engl J Med , vol.340 , pp. 1198-1200
    • Thomas, G.M.1
  • 34
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster JA, Harris AL, Davidson SE, Logue JP, Hunter RD, Wycoff CC, Pastorek J, Ratcliffe PJ, Stratford IJ, West CM: Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res 2001, 61:6394-6399
    • (2001) Cancer Res , vol.61 , pp. 6394-6399
    • Loncaster, J.A.1    Harris, A.L.2    Davidson, S.E.3    Logue, J.P.4    Hunter, R.D.5    Wycoff, C.C.6    Pastorek, J.7    Ratcliffe, P.J.8    Stratford, I.J.9    West, C.M.10
  • 36
    • 0034900493 scopus 로고    scopus 로고
    • Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix
    • Airley R, Loncaster J, Davidson S, Bromley M, Roberts S, Patterson A, Hunter R, Stratford I, West C: Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix. Clin Cancer Res 2001, 7:928-934
    • (2001) Clin Cancer Res , vol.7 , pp. 928-934
    • Airley, R.1    Loncaster, J.2    Davidson, S.3    Bromley, M.4    Roberts, S.5    Patterson, A.6    Hunter, R.7    Stratford, I.8    West, C.9
  • 37
    • 0033922706 scopus 로고    scopus 로고
    • Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis
    • Rofstad EK, Sundfor K, Lyng H, Trope CG: Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis. Br J Cancer 2000, 83:354-359
    • (2000) Br J Cancer , vol.83 , pp. 354-359
    • Rofstad, E.K.1    Sundfor, K.2    Lyng, H.3    Trope, C.G.4
  • 39
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P: Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996, 56:4509-4515
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 40
    • 0035893396 scopus 로고    scopus 로고
    • Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors
    • Cairns RA, Kalliomaki T, Hill RP: Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors. Cancer Res 2001, 61:8903-8908
    • (2001) Cancer Res , vol.61 , pp. 8903-8908
    • Cairns, R.A.1    Kalliomaki, T.2    Hill, R.P.3
  • 41
    • 0034037286 scopus 로고    scopus 로고
    • Microenvironment-induced cancer metastasis
    • Rofstad EK: Microenvironment-induced cancer metastasis. Int J Radiat Biol 2000, 76:589-605
    • (2000) Int J Radiat Biol , vol.76 , pp. 589-605
    • Rofstad, E.K.1
  • 44
    • 0036272812 scopus 로고    scopus 로고
    • Preconditioning-mediated neuroprotection: Role of nitric oxide, cGMP, and new protein expression
    • Andoh T, Chock PB, Chiueh CC: Preconditioning-mediated neuroprotection: role of nitric oxide, cGMP, and new protein expression. Ann NY Acad Sci 2002, 962:1-7
    • (2002) Ann NY Acad Sci , vol.962 , pp. 1-7
    • Andoh, T.1    Chock, P.B.2    Chiueh, C.C.3
  • 46
    • 0040389654 scopus 로고    scopus 로고
    • Expression of nuclear redox factor ref-1 in the rat hippocampus following global ischemia induced by cardiac arrest
    • Gillardon F, Bottiger B, Hossmann KA: Expression of nuclear redox factor ref-1 in the rat hippocampus following global ischemia induced by cardiac arrest. Brain Res Mol Brain Res 1997, 52:194-200
    • (1997) Brain Res Mol Brain Res , vol.52 , pp. 194-200
    • Gillardon, F.1    Bottiger, B.2    Hossmann, K.A.3
  • 49
    • 0033118983 scopus 로고    scopus 로고
    • Molecular mechanisms of transcription activation by HLF and HIF 1alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
    • Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y: Molecular mechanisms of transcription activation by HLF and HIF 1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J 1999, 18: 1905-1914
    • (1999) EMBO J , vol.18 , pp. 1905-1914
    • Ema, M.1    Hirota, K.2    Mimura, J.3    Abe, H.4    Yodoi, J.5    Sogawa, K.6    Poellinger, L.7    Fujii-Kuriyama, Y.8
  • 50
    • 0032574770 scopus 로고    scopus 로고
    • Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals
    • Ramana CV, Boldogh I, Izumi T, Mitra S: Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc Natl Acad Sci USA 1998, 95:5061-5066
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5061-5066
    • Ramana, C.V.1    Boldogh, I.2    Izumi, T.3    Mitra, S.4


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