Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation

Nucleic Acids Research

Volumn 29, Issue 14, 2001, Pages 3116-3122

  Hsieh, Marlene M ^a   Hegde, Vijay ^a   Kelley, Mark R ^b   Deutsch, Walter A ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; HYPOCHLORITE; MESSENGER RNA; MESYLIC ACID METHYL ESTER; OXIDIZING AGENT; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHODIESTERASE; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PURINE; PYRIMIDINE; REACTIVE OXYGEN METABOLITE; TAR;

AEROBIC CAPACITY; APURINIC SITE; APYRIMIDINIC SITE; ARTICLE; CANCER; CELL RESPIRATION; CIGARETTE SMOKING; COMBUSTION; CONTROLLED STUDY; CORRELATION FUNCTION; DNA DAMAGE; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; EXPOSURE; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; MACROMOLECULE; OXIDATION REDUCTION REACTION; PARTICULATE MATTER; PATHOLOGY; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA SYNTHESIS; SMOKE; STIMULUS RESPONSE;

ALOCASIA MACRORRHIZOS;

EID: 0035879047     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.14.3116     Document Type: Article

References (21)

1. Rate of chain breakage at apurinic sites in double-stranded deoxyribonucleic acid
2. Mutagenesis by apurinic/apyrimidinic sites
3. Purification and characterization of an apurinic/apyrimidinic endonuclease from HeLa cells
4. Apurinic/apyrimidinic endonucleases in repair of pyrimidine dimers and other lesions in DNA
5. Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair
6. Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway
7. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: Definition of a family of DNA repair enzymes
8. Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E.coli xth (exonuclease III) mutants
9. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
10. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains
11. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
12. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
13. Ref-1 controls pax-8 DNA-binding activity
14. Identification of redox/repair protein Ref-1 as a potent activator of p53
15. p53, the cellular gatekeeper for growth and division
16. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals
17. The DNA repair activity of human redox/repair protein APE/Ref-1 is inactivated by phosphorylation
18. Activation of protein kinase C triggers its ubiquitination and degradation
19. Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1
20. Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation
21. Protein kinase C signaling and oxidative stress