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Volumn 9, Issue 9, 2002, Pages 831-839

The GIST of targeted cancer therapy: A tumor (gastrointestinal stromal tumor), a mutated gene (c-kit), and a molecular inhibitor (STI571)

Author keywords

c kit Proto oncogene; Gastrointestinal stromal tumor; GIST; STI571

Indexed keywords

CISPLATIN; DACARBAZINE; DOXORUBICIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; IFOSFAMIDE; IMATINIB; MITOMYCIN; PROTEIN TYROSINE KINASE; STEM CELL FACTOR RECEPTOR;

EID: 0036841799     PISSN: 10689265     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02557518     Document Type: Review
Times cited : (141)

References (51)
  • 1
    • 0031947592 scopus 로고    scopus 로고
    • Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal
    • Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM. Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 1998;152:1259-69.
    • (1998) Am J Pathol , vol.152 , pp. 1259-1269
    • Kindblom, L.G.1    Remotti, H.E.2    Aldenborg, F.3    Meis-Kindblom, J.M.4
  • 2
    • 84965085738 scopus 로고
    • Bizarre smooth muscle tumors of the stomach
    • Stout AP. Bizarre smooth muscle tumors of the stomach. Cancer 1962;15:400-9.
    • (1962) Cancer , vol.15 , pp. 400-409
    • Stout, A.P.1
  • 3
    • 0021344548 scopus 로고
    • Malignant small bowel neoplasm of enteric plexus derivation (plexosarcoma): Light and electron microscopic study confirming the origin of the neoplasm
    • Herrera GA, Demoraes HP, Grizzle WE, Han SG. Malignant small bowel neoplasm of enteric plexus derivation (plexosarcoma): Light and electron microscopic study confirming the origin of the neoplasm. Dig Dis Sci 1984;29:275-84.
    • (1984) Dig Dis Sci , vol.29 , pp. 275-284
    • Herrera, G.A.1    Demoraes, H.P.2    Grizzle, W.E.3    Han, S.G.4
  • 4
    • 0024359742 scopus 로고
    • Gastrointestinal autonomic nerve tumors. 'Plexosarcomas'
    • Herrera GA, Cerezo L, Jones JE, et al. Gastrointestinal autonomic nerve tumors. 'Plexosarcomas'. Arch Pathol Lab Med 1989;113:846-53.
    • (1989) Arch Pathol Lab Med , vol.113 , pp. 846-853
    • Herrera, G.A.1    Cerezo, L.2    Jones, J.E.3
  • 5
    • 0031857113 scopus 로고    scopus 로고
    • CD117: A sensitive marker for gastrointestinal stromal tumors that is more specific than CD34
    • Sarlomo-Rikala M, Kovatich AJ. Barusevicius A, Miettinen M. CD117: A sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol 1998;11:728-34.
    • (1998) Mod Pathol , vol.11 , pp. 728-734
    • Sarlomo-Rikala, M.1    Kovatich, A.J.2    Barusevicius, A.3    Miettinen, M.4
  • 6
    • 0033984319 scopus 로고    scopus 로고
    • Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival
    • DeMatteo RP, Lewis JL, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival. Ann Surg 2000; 231:51-8.
    • (2000) Ann Surg , vol.231 , pp. 51-58
    • DeMatteo, R.P.1    Lewis, J.L.2    Leung, D.3    Mudan, S.S.4    Woodruff, J.M.5    Brennan, M.F.6
  • 7
    • 0018742458 scopus 로고
    • The triad of gastric epithelioid leiomyosarcoma, functioning extra-adrenal paraganglioma, and pulmonary chondroma
    • Carney JA. The triad of gastric epithelioid leiomyosarcoma, functioning extra-adrenal paraganglioma, and pulmonary chondroma. Cancer 1979;43:374-82.
    • (1979) Cancer , vol.43 , pp. 374-382
    • Carney, J.A.1
  • 8
    • 0032884854 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: Recent advances in understanding of their biology
    • Miettinen M, Sarlomo-Rikala M, Lasota J. Gastrointestinal stromal tumors: Recent advances in understanding of their biology. Hum Pathol 1999;30:1213-20.
    • (1999) Hum Pathol , vol.30 , pp. 1213-1220
    • Miettinen, M.1    Sarlomo-Rikala, M.2    Lasota, J.3
  • 9
    • 0026598711 scopus 로고
    • Prognostic factors influencing survival in gastrointestinal leiomyosarcomas. Implications for surgical management and staging
    • Ng EH, Pollock RE, Munsell MF, Atkinson EN, Romsdahl MM. Prognostic factors influencing survival in gastrointestinal leiomyosarcomas. Implications for surgical management and staging. Ann Surg 1992;215:68-77.
    • (1992) Ann Surg , vol.215 , pp. 68-77
    • Ng, E.H.1    Pollock, R.E.2    Munsell, M.F.3    Atkinson, E.N.4    Romsdahl, M.M.5
  • 10
    • 0035122393 scopus 로고    scopus 로고
    • Malignant gastrointestinal stromal tumors of the small intestine: A review of 50 cases from a prospective database
    • Crosby JA, Catton CN, Davis A, et al. Malignant gastrointestinal stromal tumors of the small intestine: A review of 50 cases from a prospective database. Ann Surg Oncol 2001;8:50-9.
    • (2001) Ann Surg Oncol , vol.8 , pp. 50-59
    • Crosby, J.A.1    Catton, C.N.2    Davis, A.3
  • 11
    • 0035086040 scopus 로고    scopus 로고
    • Adjuvant radiotherapy for gastrointestinal stromal tumor of the rectum
    • Pollock J, Morgan D, Denobile J, Williams J. Adjuvant radiotherapy for gastrointestinal stromal tumor of the rectum. Dig Dis Sci 2001;46:268-72.
    • (2001) Dig Dis Sci , vol.46 , pp. 268-272
    • Pollock, J.1    Morgan, D.2    Denobile, J.3    Williams, J.4
  • 12
    • 0026543276 scopus 로고
    • Prognostic implications of patterns of failure for gastrointestinal leiomyosarcomas
    • Ng EH, Pollock RE, Romsdahl MM. Prognostic implications of patterns of failure for gastrointestinal leiomyosarcomas. Cancer 1992;69:1334-41.
    • (1992) Cancer , vol.69 , pp. 1334-1341
    • Ng, E.H.1    Pollock, R.E.2    Romsdahl, M.M.3
  • 13
    • 0000084433 scopus 로고    scopus 로고
    • Contrast of response to D-MAP + sargramostim between patients with advance malignant gastrointestinal stromal tumors and patients with other advanced leiomyosarcomas
    • Edmondson J, Marks R, Buckner J, Mahoney M. Contrast of response to D-MAP + sargramostim between patients with advance malignant gastrointestinal stromal tumors and patients with other advanced leiomyosarcomas. Proc Am Soc Clin Oncol 1999;18:541.
    • (1999) Proc Am Soc Clin Oncol , vol.18 , pp. 541
    • Edmondson, J.1    Marks, R.2    Buckner, J.3    Mahoney, M.4
  • 15
    • 0034666327 scopus 로고    scopus 로고
    • Soft tissue leiomyosarcomas and malignant gastrointestinal stromal tumors: Differences in clinical outcome and expression of multidrug resistance proteins
    • Plaat BE. Hollema H, Molenaar WM, et al. Soft tissue leiomyosarcomas and malignant gastrointestinal stromal tumors: Differences in clinical outcome and expression of multidrug resistance proteins. J Clin Oncol 2000;18:3211-20.
    • (2000) J Clin Oncol , vol.18 , pp. 3211-3220
    • Plaat, B.E.1    Hollema, H.2    Molenaar, W.M.3
  • 16
    • 0033105659 scopus 로고    scopus 로고
    • Quantitative methodologies for selection of patients with recurrent abdominopelvic sarcoma for treatment
    • Berthet B, Sugarbaker TA, Chang D, Sugarbaker PH. Quantitative methodologies for selection of patients with recurrent abdominopelvic sarcoma for treatment. Eur J Cancer 1999;35:413-9.
    • (1999) Eur J Cancer , vol.35 , pp. 413-419
    • Berthet, B.1    Sugarbaker, T.A.2    Chang, D.3    Sugarbaker, P.H.4
  • 19
    • 0025017802 scopus 로고
    • Phase II trial of intraperitoneal mitoxantrone in the management of refractory ovarian cancer
    • Markman M, George M, Hakes T, et al. Phase II trial of intraperitoneal mitoxantrone in the management of refractory ovarian cancer. J Clin Oncol 1990;8:146-50.
    • (1990) J Clin Oncol , vol.8 , pp. 146-150
    • Markman, M.1    George, M.2    Hakes, T.3
  • 21
    • 0342369352 scopus 로고    scopus 로고
    • Hepatic metastases from leiomyosarcoma: A single-center experience with 34 liver resections during a 15-year period
    • Lang H, Nussbaum KT, Kaudel P, Fruhauf N, Flemming P, Raab R. Hepatic metastases from leiomyosarcoma: A single-center experience with 34 liver resections during a 15-year period. Ann Surg 2000;231:500-5.
    • (2000) Ann Surg , vol.231 , pp. 500-505
    • Lang, H.1    Nussbaum, K.T.2    Kaudel, P.3    Fruhauf, N.4    Flemming, P.5    Raab, R.6
  • 22
    • 0035117662 scopus 로고    scopus 로고
    • Sarcomas metastatic to the liver: Response and survival after cisplatin, doxorubicin, mitomycin-C, Ethiodol, and polyvinyl alcohol chemoembolization
    • Rajan DK, Soulen MC, Clark TW, et al. Sarcomas metastatic to the liver: Response and survival after cisplatin, doxorubicin, mitomycin-C, Ethiodol, and polyvinyl alcohol chemoembolization. J Vasc Interv Radiol 2001;12:187-93.
    • (2001) J Vasc Interv Radiol , vol.12 , pp. 187-193
    • Rajan, D.K.1    Soulen, M.C.2    Clark, T.W.3
  • 23
    • 0028958778 scopus 로고
    • Gastrointestinal leiomyosarcoma metastatic to the liver. Durable tumor regression by hepatic chemoembolization infusion with cisplatin and vinblastine
    • Mavligit GM, Zukwiski AA, Ellis LM, Chuang VP, Wallace S, Gastrointestinal leiomyosarcoma metastatic to the liver. Durable tumor regression by hepatic chemoembolization infusion with cisplatin and vinblastine. Cancer 1995;75:2083-8.
    • (1995) Cancer , vol.75 , pp. 2083-2088
    • Mavligit, G.M.1    Zukwiski, A.A.2    Ellis, L.M.3    Chuang, V.P.4    Wallace, S.5
  • 24
    • 2742529418 scopus 로고
    • Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand
    • Yarden Y, Kuang WJ, Yang-Feng T, et al. Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1987;6:3341-51.
    • (1987) EMBO J , vol.6 , pp. 3341-3351
    • Yarden, Y.1    Kuang, W.J.2    Yang-Feng, T.3
  • 25
    • 0022626874 scopus 로고
    • A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family
    • Besmer P, Murphy JE, George PC, et al. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 1986;320:415-21.
    • (1986) Nature , vol.320 , pp. 415-421
    • Besmer, P.1    Murphy, J.E.2    George, P.C.3
  • 26
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998; 279:577-80.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 27
    • 0033883060 scopus 로고    scopus 로고
    • KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
    • Lux ML, Rubin BP, Biase TL, et al. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am J Pathol 2000;156:791-5.
    • (2000) Am J Pathol , vol.156 , pp. 791-795
    • Lux, M.L.1    Rubin, B.P.2    Biase, T.L.3
  • 28
    • 0000244046 scopus 로고    scopus 로고
    • Evaluation of the molecularly targeted therapy STI 571 in patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT
    • Blanke CD, von Mehren M, Joensuu H, et al. Evaluation of the molecularly targeted therapy STI 571 in patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT. Proc Am Soc Clin Oncol 2001;20:2. Available at: http://virtualmeeting. asco.org/vm2001/interest_areas/special_sessions/plenary.htm. Accessed: September 3, 2002.
    • (2001) Proc Am Soc Clin Oncol
    • Blanke, C.D.1    Von Mehren, M.2    Joensuu, H.3
  • 29
    • 0031848146 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal turnouts with germline mutation of the KIT gene
    • Nishida T. Familial gastrointestinal stromal turnouts with germline mutation of the KIT gene. Nat Genet 1998;19:323-4.
    • (1998) Nat Genet , vol.19 , pp. 323-324
    • Nishida, T.1
  • 30
    • 0034993741 scopus 로고    scopus 로고
    • Classes of c-KIT activating mutations: Proposed mechanisms of action and implications for disease classification and therapy
    • Longley BJ, Reguera MJ, Ma Y. Classes of c-KIT activating mutations: Proposed mechanisms of action and implications for disease classification and therapy. Leuk Res 2001;25:571-6.
    • (2001) Leuk Res , vol.25 , pp. 571-576
    • Longley, B.J.1    Reguera, M.J.2    Ma, Y.3
  • 31
    • 0032953812 scopus 로고    scopus 로고
    • Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas
    • Lasota J, Jasinski M, Sarlomo-Rikala M, Miettinen M. Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas. Am J Pathol 1999;154:53-60.
    • (1999) Am J Pathol , vol.154 , pp. 53-60
    • Lasota, J.1    Jasinski, M.2    Sarlomo-Rikala, M.3    Miettinen, M.4
  • 32
    • 0033199890 scopus 로고    scopus 로고
    • Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors
    • Taniguchi M, Nishida T, Hirota S, et al. Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors. Cancer Res 1999;59: 4297-300.
    • (1999) Cancer Res , vol.59 , pp. 4297-4300
    • Taniguchi, M.1    Nishida, T.2    Hirota, S.3
  • 33
    • 0034660868 scopus 로고    scopus 로고
    • DNA sequence copy number changes in gastrointestinal stromal tumors: Tumor progression and prognostic significance
    • El Rifai W, Sarlomo-Rikala M, Andersson LC, Knuutila S, Miettinen M. DNA sequence copy number changes in gastrointestinal stromal tumors: Tumor progression and prognostic significance. Cancer Res 2000;60:3899-903.
    • (2000) Cancer Res , vol.60 , pp. 3899-3903
    • El Rifai, W.1    Sarlomo-Rikala, M.2    Andersson, L.C.3    Knuutila, S.4    Miettinen, M.5
  • 35
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ. Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996;2:561-6.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 36
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001;344:1031-7.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 37
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001;344:1038-42.
    • (2001) N Engl J Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3
  • 38
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
    • Buchdunger E, Zimmermann J, Mett H, et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res 1996;56:100-4.
    • (1996) Cancer Res , vol.56 , pp. 100-104
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3
  • 39
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells, Nat Med 1996;2:561-6.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 40
    • 0033816156 scopus 로고    scopus 로고
    • Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
    • Buchdunger E, Cioffi CL, Law N, et al. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 2000;295:139-45.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 139-145
    • Buchdunger, E.1    Cioffi, C.L.2    Law, N.3
  • 41
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of c-kit receptor tyrosine kinase activity by STI571, a selective tyrosine kinase inhibitor
    • Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ. Inhibition of c-kit receptor tyrosine kinase activity by STI571, a selective tyrosine kinase inhibitor. Blood 2000;96:925-32.
    • (2000) Blood , vol.96 , pp. 925-932
    • Heinrich, M.C.1    Griffith, D.J.2    Druker, B.J.3    Wait, C.L.4    Ott, K.A.5    Zigler, A.J.6
  • 42
    • 0035899418 scopus 로고    scopus 로고
    • STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications
    • Tuveson DA, Willis NA, Jacks T, et al. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications. Oncogene 2001:20:5054-8.
    • (2001) Oncogene , vol.20 , pp. 5054-5058
    • Tuveson, D.A.1    Willis, N.A.2    Jacks, T.3
  • 43
    • 0035810148 scopus 로고    scopus 로고
    • Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor
    • Joensuu H, Roberts PJ, Sarlomo-Rikala M, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 2001;344:1052-6.
    • (2001) N Engl J Med , vol.344 , pp. 1052-1056
    • Joensuu, H.1    Roberts, P.J.2    Sarlomo-Rikala, M.3
  • 44
    • 0002499759 scopus 로고    scopus 로고
    • STI 571, an active drug in metastatic gastrointestinal stromal tumors (GIST), an EORTC phase I study
    • Van Oosterom AT, Judson I, Verweij J, et al. STI 571, an active drug in metastatic gastrointestinal stromal tumors (GIST), an EORTC phase I study. Proc Am Soc Clin Oncol 2001;20:2.
    • (2001) Proc Am Soc Clin Oncol , vol.20 , pp. 2
    • Van Oosterom, A.T.1    Judson, I.2    Verweij, J.3
  • 45
    • 0035960428 scopus 로고    scopus 로고
    • Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumors: A phase I study
    • Van Oosterom AT, Judson I, Verweij J, et al. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumors: A phase I study. Lancet 2001;358:1421-3.
    • (2001) Lancet , vol.358 , pp. 1421-1423
    • Van Oosterom, A.T.1    Judson, I.2    Verweij, J.3
  • 46
    • 0011092772 scopus 로고    scopus 로고
    • American College of Surgeons Oncology Group. http://www. acosog.org. 2002.
    • (2002)
  • 47
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001;293:876-80.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 48
    • 0034161460 scopus 로고    scopus 로고
    • Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification
    • le Coutre P, Tassi E, Varella-Garcia M, et al, Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. Blood 2000;95:1758-66.
    • (2000) Blood , vol.95 , pp. 1758-1766
    • Le Coutre, P.1    Tassi, E.2    Varella-Garcia, M.3
  • 49
    • 0034254368 scopus 로고    scopus 로고
    • Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: Diverse mechanisms of resistance
    • Mahon FX, Deininger MW, Schultheis B, et al. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: Diverse mechanisms of resistance. Blood 2000;96:1070-9.
    • (2000) Blood , vol.96 , pp. 1070-1079
    • Mahon, F.X.1    Deininger, M.W.2    Schultheis, B.3
  • 50
    • 0034210577 scopus 로고    scopus 로고
    • Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines
    • Weisberg E, Griffin JD. Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines. Blood 2000;95:3498-505.
    • (2000) Blood , vol.95 , pp. 3498-3505
    • Weisberg, E.1    Griffin, J.D.2
  • 51
    • 0036467568 scopus 로고    scopus 로고
    • Rational therapeutic intervention in cancer: Kinases as drug targets
    • Sawyers CL. Rational therapeutic intervention in cancer: Kinases as drug targets. Curr Opin Genet Dev 2002;12:111-5.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 111-115
    • Sawyers, C.L.1


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