Mutations in c-kit gene exons 9 and 13 in gastrointestinal stromal tumors among Japanese

Japanese Journal of Cancer Research

Volumn 92, Issue 5, 2001, Pages 494-498

  Sakurai, Shinji ^a   Oguni, Sachiko ^a   Hironaka, Mitsugu ^a   Fukayama, Masashi ^b   Morinaga, Shojiroh ^a   Saito, Ken ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

C kit; Exons 9 and 13; GIST; Mutation

Indexed keywords

ADENINE; CYTOSINE; GUANINE; STEM CELL FACTOR; THYMINE;

ADULT; AGED; ARTICLE; CANCER MORTALITY; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; EXON; GASTROINTESTINAL TUMOR; GENE INSERTION; GENE MUTATION; GENE SEQUENCE; HIGH RISK POPULATION; HUMAN; IMMUNOHISTOCHEMISTRY; JAPAN; MALE; METASTASIS; PATHOLOGY; POLYMERASE CHAIN REACTION; POPULATION; PRIORITY JOURNAL; PROGNOSIS; PROTO ONCOGENE; SINGLE STRAND CONFORMATION POLYMORPHISM; SMALL INTESTINE CANCER; STROMA; WESTERN HEMISPHERE;

ACTINS; ADULT; AGED; ANTIGENS, CD34; DNA, NEOPLASM; DUODENAL NEOPLASMS; EXONS; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL NEOPLASMS; JAPAN; MALE; MIDDLE AGED; MUTATION; NEOPLASM METASTASIS; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTO-ONCOGENE PROTEINS C-KIT; RISK FACTORS; STOMACH NEOPLASMS;

EID: 0034981645     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb01121.x     Document Type: Article

References (22)

1. Gastrointestinal stromal tumors. An immunohistochemical study of cellular differentiation
2. A clinicopathologic and immunohistochemical study of gastrointestinal stromal tumors
3. Muscle differentiation and clinicopathological features of gastrointestinal stromal tumors
4. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
5. Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal
6. CD117: A sensitive marker for gastrointestinal stromal tumors that is more specific than CD34
7. Embryonic form of smooth muscle myosin heavy chain (SMemb/MHC-B) in gastrointestinal stromal tumor and interstitial cells of Cajal
8. KIT mutation portends poor prognosis in gastrointestinal stromal/smooth muscle tumors
9. Mutations in exon 11 of c-kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas
10. Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors
11. C-kit gene abnormalities in gastrointestinal stromal tumors (tumors of interstitial cells of Cajal)
12. Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors
13. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
14. Mutations in exons 9 and 13 of kit gene are rare events in gastrointestinal stromal tumors
15. Germline-activating mutations in the kinase domain of KIT gene in familial gastrointestinal stromal tumors
16. Gastrointestinal stromal tumors and KIT-positive mesenchymal cells in the omentum
17. Different patterns of DNA copy number changes in gastrointestinal stromal tumors, leiomyomas, and schwannomas
18. Allelic loss of 14q and 22q, NF2 mutation, and genetic instability occur independently of c-kit mutations in gastrointestinal stromal tumor
19. Coexpression of the c-kit and stem cell factor genes in breast carcinomas
20. An in vivo model for receptor tyrosine kinase autocrine/paracrine activation: Auto-stimulated KIT receptor acts as a tumor promoting factor in papillomavirus-induced tumorigenesis
21. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor
22. Lack of expression of c-kit in ovarian cancers is associated with poor prognosis