-
1
-
-
0034820160
-
Autophagy in yeast: Mechanistic insights and physiological functions
-
Abeliovich H., Klionsky D.J. Autophagy in yeast: mechanistic insights and physiological functions. Mol. Biol. Rev. 65:2001;463-479.
-
(2001)
Mol. Biol. Rev.
, vol.65
, pp. 463-479
-
-
Abeliovich, H.1
Klionsky, D.J.2
-
2
-
-
0035430138
-
Mutations prolong life in flies implications for aging in mammals
-
Bartke A. Mutations prolong life in flies implications for aging in mammals. Trends Endocrinol. Metab. 12:2001;233-234.
-
(2001)
Trends Endocrinol. Metab.
, vol.12
, pp. 233-234
-
-
Bartke, A.1
-
3
-
-
0031916984
-
The free radical theory of aging matures
-
Beckman K., Ames B.N. The free radical theory of aging matures. Physiol. Rev. 78:1998;547-581.
-
(1998)
Physiol. Rev.
, vol.78
, pp. 547-581
-
-
Beckman, K.1
Ames, B.N.2
-
4
-
-
0043204997
-
The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically
-
Bergamini E., Cavallini A., Gori D.Z. The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically. Biomed. Pharmacother. 57:2003;203-208.
-
(2003)
Biomed. Pharmacother.
, vol.57
, pp. 203-208
-
-
Bergamini, E.1
Cavallini, A.2
Gori, D.Z.3
-
5
-
-
0028878309
-
Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle
-
Biolo G., Fleming R.Y.D., Maggi S.P., Wolfe R.R. Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am. J. Physiol. 268:1995a;E75-E84.
-
(1995)
Am. J. Physiol.
, vol.268
, pp. 75-E84
-
-
Biolo, G.1
Fleming, R.Y.D.2
Maggi, S.P.3
Wolfe, R.R.4
-
6
-
-
0028837394
-
Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle
-
Biolo G., Fleming R.Y.D., Wolfe R.R. Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. J. Clin. Invest. 95:1995b;811-819.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 811-819
-
-
Biolo, G.1
Fleming, R.Y.D.2
Wolfe, R.R.3
-
7
-
-
0028899789
-
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
-
Blommaart E.F.C., Luiken J.J.F.P., Blommaart P.J.E., van Woerkom G.M., Meijer A.J. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J. Biol. Chem. 270:1995;2320-2326.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 2320-2326
-
-
Blommaart, E.F.C.1
Luiken, J.J.F.P.2
Blommaart, P.J.E.3
Van Woerkom, G.M.4
Meijer, A.J.5
-
8
-
-
8044257699
-
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
-
Blommaart E.F.C., Krause U., Schellens J.P.M., Vreeling- Sindelárová H., Meijer A.J. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem. 243:1997;240-246.
-
(1997)
Eur. J. Biochem.
, vol.243
, pp. 240-246
-
-
Blommaart, E.F.C.1
Krause, U.2
Schellens, J.P.M.3
Vreeling- Sindelárová, H.4
Meijer, A.J.5
-
9
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue
-
Blüher M., Kahn B.B., Kahn C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 299:2003;572-574.
-
(2003)
Science
, vol.299
, pp. 572-574
-
-
Blüher, M.1
Kahn, B.B.2
Kahn, C.R.3
-
10
-
-
0035736260
-
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
-
Bodine S.C., Stitt T.N., Gonzalez M., Kline W.O., Stover G.L., Bauerlein R., Zlotchenko E., Scrimgeourt A., Lawrence J.C., Glass D.J., Yancopoulos G.D. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat. Cell Biol. 3:2001;1014-1019.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 1014-1019
-
-
Bodine, S.C.1
Stitt, T.N.2
Gonzalez, M.3
Kline, W.O.4
Stover, G.L.5
Bauerlein, R.6
Zlotchenko, E.7
Scrimgeourt, A.8
Lawrence, J.C.9
Glass, D.J.10
Yancopoulos, G.D.11
-
11
-
-
0028350792
-
Effect of aging on human skeletal muscle and motor function
-
Booth F.W., Weeden S.H., Tseng B.S. Effect of aging on human skeletal muscle and motor function. Med. Sci. Sports Exerc. 26:1994;556-560.
-
(1994)
Med. Sci. Sports Exerc.
, vol.26
, pp. 556-560
-
-
Booth, F.W.1
Weeden, S.H.2
Tseng, B.S.3
-
12
-
-
0027936874
-
Composition of gomori-positive inclusions in astrocytes of the hypothalamic arcuate nucleus
-
Brawer J.R., Stein R., Small L., Cissé S., Schipper H.M. Composition of gomori-positive inclusions in astrocytes of the hypothalamic arcuate nucleus. Anat. Rec. 240:1994;407-415.
-
(1994)
Anat. Rec.
, vol.240
, pp. 407-415
-
-
Brawer, J.R.1
Stein, R.2
Small, L.3
Cissé, S.4
Schipper, H.M.5
-
13
-
-
0021926933
-
Prospects for an aging population
-
Brody J.A. Prospects for an aging population. Nature. 315:1985;463-466.
-
(1985)
Nature
, vol.315
, pp. 463-466
-
-
Brody, J.A.1
-
14
-
-
0036236006
-
The mitochondrial lysosomal axis theory of aging. Accumulation of damaged mitochondria as a result of imperfect autophagocytosis
-
Brunk U.T., Terman A. The mitochondrial lysosomal axis theory of aging. Accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur. J. Biochem. 269:2002;1996-2002.
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 1996-2002
-
-
Brunk, U.T.1
Terman, A.2
-
15
-
-
0028237230
-
The oldest old
-
Campion E.W. The oldest old. New Engl. J. Med. 330:1994;1819-1820.
-
(1994)
New Engl. J. Med.
, vol.330
, pp. 1819-1820
-
-
Campion, E.W.1
-
16
-
-
0035815414
-
Extension of life-span by loss of chico, a Drosophila insulin receptor substrate protein
-
Clancy D.J., Gems D., Harshman L.G., Oldham S., Stocker H., Hafen E., Leevers S.J., Partridge L. Extension of life-span by loss of chico, a Drosophila insulin receptor substrate protein. Science. 292:2001;104-106.
-
(2001)
Science
, vol.292
, pp. 104-106
-
-
Clancy, D.J.1
Gems, D.2
Harshman, L.G.3
Oldham, S.4
Stocker, H.5
Hafen, E.6
Leevers, S.J.7
Partridge, L.8
-
18
-
-
0036241731
-
Three detailed hypotheses implicating oxidative damage to mitochondria as a major driving force in homeotherm aging
-
de Grey A.D.N.J. Three detailed hypotheses implicating oxidative damage to mitochondria as a major driving force in homeotherm aging. Eur. J. Biochem. 269:2002;1995.
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 1995
-
-
De Grey, A.D.N.J.1
-
19
-
-
0026316130
-
Proteolysis in skeletal muscle and whole body response to euglycemic hyperinsulinemia in normal adults
-
Denne S.C., Liechty E.A., Liu Y.M., Brechtel G., Baron A.D. Proteolysis in skeletal muscle and whole body response to euglycemic hyperinsulinemia in normal adults. Am. J. Physiol. 261:1991;E809-E814.
-
(1991)
Am. J. Physiol.
, vol.261
, pp. 809-E814
-
-
Denne, S.C.1
Liechty, E.A.2
Liu, Y.M.3
Brechtel, G.4
Baron, A.D.5
-
20
-
-
0033213918
-
Translation initiation: Adept at adapting
-
Dever T.E. Translation initiation: adept at adapting. TIBS. 24:1999;398-403.
-
(1999)
TIBS
, vol.24
, pp. 398-403
-
-
Dever, T.E.1
-
21
-
-
0023545339
-
Molecular determinants of protein half- lives in eukaryotic cells
-
Dice J.F. Molecular determinants of protein half- lives in eukaryotic cells. FASEB J. 1:1987;349-356.
-
(1987)
FASEB J.
, vol.1
, pp. 349-356
-
-
Dice, J.F.1
-
22
-
-
0025340880
-
Studies on the mechanisms of autophagy: Maturation of the autophagic vacuole
-
Dunn W.A. Studies on the mechanisms of autophagy: maturation of the autophagic vacuole. J. Cell Biol. 110:1990;1935-1945.
-
(1990)
J. Cell Biol.
, vol.110
, pp. 1935-1945
-
-
Dunn, W.A.1
-
23
-
-
0035487007
-
The mitochondrial permeability transition initiates autophagy in rat hepatocytes
-
(doi:10.1096/fj.01-0206fje).
-
Elmore, S.P., Qian, T., Grissom, S.F., Lemasters, J.J., 2001. The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J. 2286-2287 (doi:10.1096/fj.01-0206fje).
-
(2001)
FASEB J.
, pp. 2286-2287
-
-
Elmore, S.P.1
Qian, T.2
Grissom, S.F.3
Lemasters, J.J.4
-
25
-
-
0024845562
-
Amino acids augment insulin's suppression of whole body proteolysis
-
Flakoll P.J., Kulaylat M., Frexes-Steed M., Hourani H., Brown L.L., Hill J.O., Abumrad N.N. Amino acids augment insulin's suppression of whole body proteolysis. Am. J. Physiol. 257:1989;E839-E847.
-
(1989)
Am. J. Physiol.
, vol.257
, pp. 839-E847
-
-
Flakoll, P.J.1
Kulaylat, M.2
Frexes-Steed, M.3
Hourani, H.4
Brown, L.L.5
Hill, J.O.6
Abumrad, N.N.7
-
27
-
-
0022338995
-
Insulin-mediated reduction of whole body protein breakdown. Dose-response effects on leucine metabolism in post-absorptive men
-
Fukagawa N.K., Minaker K.L., Rowe J.W., Goodman M.N., Matthews D.E., Bier D.M., Young V.R. Insulin-mediated reduction of whole body protein breakdown. Dose-response effects on leucine metabolism in post-absorptive men. J. Clin. Invest. 76:1985;2306-2311.
-
(1985)
J. Clin. Invest.
, vol.76
, pp. 2306-2311
-
-
Fukagawa, N.K.1
Minaker, K.L.2
Rowe, J.W.3
Goodman, M.N.4
Matthews, D.E.5
Bier, D.M.6
Young, V.R.7
-
28
-
-
0024554421
-
Leucine metabolism in aging humans: Effect of insulin and substrate availability
-
Fukagawa N.K., Minaker K.L., Young V.R., Matthews D.E., Bier D.M., Rowe J.W. Leucine metabolism in aging humans: effect of insulin and substrate availability. Am. J. Physiol. 256:1989;E288-E294.
-
(1989)
Am. J. Physiol.
, vol.256
, pp. 288-E294
-
-
Fukagawa, N.K.1
Minaker, K.L.2
Young, V.R.3
Matthews, D.E.4
Bier, D.M.5
Rowe, J.W.6
-
29
-
-
0022466140
-
The activation of protein degradation in muscle by calcium or muscle injury does not involve a lysosomal mechanism
-
Furuno K., Goldberg A.L. The activation of protein degradation in muscle by calcium or muscle injury does not involve a lysosomal mechanism. Biochem. J. 237:1986;859-864.
-
(1986)
Biochem. J.
, vol.237
, pp. 859-864
-
-
Furuno, K.1
Goldberg, A.L.2
-
30
-
-
0025358894
-
Immunocytochemical study of the surrounding envelope of autophagic vacuoles in cult ured rat hepatocytes
-
Furuno K., Ishikawa T., Akasaki K., Lee S., Nishimura Y., Tsuji H., Himeno M., Kato K. Immunocytochemical study of the surrounding envelope of autophagic vacuoles in cult ured rat hepatocytes. Exp. Cell Res. 189:1990;261-268.
-
(1990)
Exp. Cell Res.
, vol.189
, pp. 261-268
-
-
Furuno, K.1
Ishikawa, T.2
Akasaki, K.3
Lee, S.4
Nishimura, Y.5
Tsuji, H.6
Himeno, M.7
Kato, K.8
-
31
-
-
0023196951
-
Effect of physiological hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man
-
Gelfand R.A., Barrett E.J. Effect of physiological hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man. J. Clin. Invest. 80:1987;1-6.
-
(1987)
J. Clin. Invest.
, vol.80
, pp. 1-6
-
-
Gelfand, R.A.1
Barrett, E.J.2
-
32
-
-
0031685525
-
Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans
-
Gems D., Sutton A.J., Sundermeyer M.L., Alberts P.S., King K.V., Edgley M.L., Larsen P.L., Riddle D.L. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics. 150:1998;129-155.
-
(1998)
Genetics
, vol.150
, pp. 129-155
-
-
Gems, D.1
Sutton, A.J.2
Sundermeyer, M.L.3
Alberts, P.S.4
King, K.V.5
Edgley, M.L.6
Larsen, P.L.7
Riddle, D.L.8
-
33
-
-
0032834055
-
EIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
-
Gingras A.-C., Raught B., Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68:1999;913-963.
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 913-963
-
-
Gingras, A.-C.1
Raught, B.2
Sonenberg, N.3
-
34
-
-
0019730097
-
Mechanisms of intralysosomal degradation with special reference to autophagocytosis of cell organelles
-
Glaumann H., Ericsson J.L., Marzella L. Mechanisms of intralysosomal degradation with special reference to autophagocytosis of cell organelles. Int. Rev. Cytol. 73:1981;149-182.
-
(1981)
Int. Rev. Cytol.
, vol.73
, pp. 149-182
-
-
Glaumann, H.1
Ericsson, J.L.2
Marzella, L.3
-
35
-
-
0032486268
-
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF4E BP1 through a common effector mechanism
-
Hara K., Yonezawa K., Weng Q.-P., Kozlowski M.T., Belham C., Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF4E BP1 through a common effector mechanism. J. Biol. Chem. 273:1998;14484-14494.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14484-14494
-
-
Hara, K.1
Yonezawa, K.2
Weng, Q.-P.3
Kozlowski, M.T.4
Belham, C.5
Avruch, J.6
-
37
-
-
0023442337
-
Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide
-
Hayes G.R., Lockwood D.H. Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide. Proc. Natl. Acad. Sci.: USA. 84:1987;8115-8119.
-
(1987)
Proc. Natl. Acad. Sci.: USA
, vol.84
, pp. 8115-8119
-
-
Hayes, G.R.1
Lockwood, D.H.2
-
38
-
-
0025193521
-
2 and vanadate stimulate protein tyrosine phosphorylation in intact cells
-
2 and vanadate stimulate protein tyrosine phosphorylation in intact cells. J. Biol. Chem. 265:1990;2896-2902.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 2896-2902
-
-
Heffetz, D.1
Bushkin, I.2
Dror, R.3
Zick, Y.4
-
39
-
-
0026663539
-
A ubiquitin system for protein degradation
-
Hershko A., Ciechanover A. A ubiquitin system for protein degradation. Annu. Rev. Biochem. 61:1992;761-807.
-
(1992)
Annu. Rev. Biochem.
, vol.61
, pp. 761-807
-
-
Hershko, A.1
Ciechanover, A.2
-
40
-
-
0026636463
-
Effect of hyperinsulinemia on whole body and skeletal muscle leucine carbon kinetics in humans
-
Heslin M.J., Newman E., Wolf R.F., Pisters P.W.T., Brennan M.F. Effect of hyperinsulinemia on whole body and skeletal muscle leucine carbon kinetics in humans. Am. J. Physiol. 262:1992;E911-E918.
-
(1992)
Am. J. Physiol.
, vol.262
, pp. 911-E918
-
-
Heslin, M.J.1
Newman, E.2
Wolf, R.F.3
Pisters, P.W.T.4
Brennan, M.F.5
-
41
-
-
1542274165
-
Insulin to impact on protein and amino acid metabolism
-
Pisters, P.W.T., Brennan, M.F. (Eds.), Springer, Berlin, Heidelberg, New York
-
Heslin, M.J., 1996. Insulin to impact on protein and amino acid metabolism. In: Pisters, P.W.T., Brennan, M.F. (Eds.), Protein and Amino Acid Metabolism in Cancer Cachexia, Landes, Georgetown. Springer, Berlin, Heidelberg, New York, pp.187-199.
-
(1996)
Protein and Amino Acid Metabolism in Cancer Cachexia, Landes, Georgetown
, pp. 187-199
-
-
Heslin, M.J.1
-
42
-
-
0347664057
-
-
Nature advance online publication, 4 December (doi:10.1038/nature01298).
-
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën A., Evens, P.C., Cervera, P., Le Bouc, Y., 2002. IGF-1 receptor regulates life span and resistance to oxidative stress in mice. Nature advance online publication, 4 December (doi:10.1038/nature01298).
-
(2002)
IGF-1 Receptor Regulates Life Span and Resistance to Oxidative Stress in Mice
-
-
Holzenberger, M.1
Dupont, J.2
Ducos, B.3
Leneuve, P.4
Géloën, A.5
Evens, P.C.6
Cervera, P.7
Le Bouc, Y.8
-
43
-
-
0028816656
-
Changes in aerobic power of men, ages 25-70 years
-
Jackson A.S., Beard E.F., Wier L.T., Ross R.M., Stuteville J.E., Blair S.N. Changes in aerobic power of men, ages 25-70 years. Med. Sci. Sports Exerc. 27:1995;113-120.
-
(1995)
Med. Sci. Sports Exerc.
, vol.27
, pp. 113-120
-
-
Jackson, A.S.1
Beard, E.F.2
Wier, L.T.3
Ross, R.M.4
Stuteville, J.E.5
Blair, S.N.6
-
44
-
-
0025004091
-
Increased life span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging
-
Johnson T.E. Increased life span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science. 249:1990;908-912.
-
(1990)
Science
, vol.249
, pp. 908-912
-
-
Johnson, T.E.1
-
45
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
Kenyon C., Chang J., Gensch E., Rudner A., Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 366:1993;461-464.
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
46
-
-
0033791650
-
Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells
-
Kim J., Klionsky D.J. Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu. Rev. Biochem. 69:2000;303-342.
-
(2000)
Annu. Rev. Biochem.
, vol.69
, pp. 303-342
-
-
Kim, J.1
Klionsky, D.J.2
-
47
-
-
0032553411
-
Implications of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts
-
Kimball S.R., Horetsky R.L., Jefferson L.S. Implications of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts. J. Biol. Chem. 273:1998;30945-30953.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 30945-30953
-
-
Kimball, S.R.1
Horetsky, R.L.2
Jefferson, L.S.3
-
48
-
-
0030813398
-
Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
-
Kimura K.D., Tissenbaum H.A., Liu Y., Ruvkun G. Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 277:1997;942-946.
-
(1997)
Science
, vol.277
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, Y.3
Ruvkun, G.4
-
49
-
-
0034537290
-
Autophagy as a regulated pathway of cellular degradation
-
Klionsky D.J., Emr S.D. Autophagy as a regulated pathway of cellular degradation. Science. 290:2000;1717-1721.
-
(2000)
Science
, vol.290
, pp. 1717-1721
-
-
Klionsky, D.J.1
Emr, S.D.2
-
50
-
-
0023931255
-
Hydrogen peroxide stimulates tyrosine phosphorylation of the insulin receptor and its tyrosine kinase activity in intact cells
-
Koshio O., Akanuma Y., Kasuga M. Hydrogen peroxide stimulates tyrosine phosphorylation of the insulin receptor and its tyrosine kinase activity in intact cells. Biochem. J. 250:1988;95-101.
-
(1988)
Biochem. J.
, vol.250
, pp. 95-101
-
-
Koshio, O.1
Akanuma, Y.2
Kasuga, M.3
-
51
-
-
0029938846
-
Protein kinase signaling pathway triggered by cell swelling and involved in the activation of glycogen synthase and acetyl CoA carboxylase in isolated rate hepatocytes
-
Krause U., Rider M.H., Hue L. Protein kinase signaling pathway triggered by cell swelling and involved in the activation of glycogen synthase and acetyl CoA carboxylase in isolated rate hepatocytes. J. Biol. Chem. 271:1996;16668-16673.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 16668-16673
-
-
Krause, U.1
Rider, M.H.2
Hue, L.3
-
53
-
-
0024541837
-
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
-
Linnane A.W., Marzuki S., Ozawa T., Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet. 25:1989;642-645.
-
(1989)
Lancet
, vol.25
, pp. 642-645
-
-
Linnane, A.W.1
Marzuki, S.2
Ozawa, T.3
Tanaka, M.4
-
54
-
-
0037007124
-
The insulin signalling pathway
-
Lizcano J.M., Alessi D.R. The insulin signalling pathway. Curr. Biol. 12:2002;R236-R238.
-
(2002)
Curr. Biol.
, vol.12
, pp. 236-R238
-
-
Lizcano, J.M.1
Alessi, D.R.2
-
55
-
-
0036306657
-
Regulation of longevity and stress resistance: A molecular strategy conserved from yeast to humans?
-
Longo V.D., Fabrizio P. Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans? Cell. Mol. Life Sci. 59:2002;903-908.
-
(2002)
Cell. Mol. Life Sci.
, vol.59
, pp. 903-908
-
-
Longo, V.D.1
Fabrizio, P.2
-
56
-
-
0037470488
-
Evolutionary medicine: From dwarf model systems to healthy centenarians?
-
Longo V.D., Finch C.E. Evolutionary medicine: from dwarf model systems to healthy centenarians? Science. 299:2003;1342-1346.
-
(2003)
Science
, vol.299
, pp. 1342-1346
-
-
Longo, V.D.1
Finch, C.E.2
-
57
-
-
0019419376
-
Protein degradation in human skeletal muscle tissue: The effect of insulin, leucine, amino acids and ions
-
Lundholm K., Edstrom S., Ekman L., Karlberg I., Walker P., Schersten T. Protein degradation in human skeletal muscle tissue: the effect of insulin, leucine, amino acids and ions. Clin. Sci. 60:1981;319-326.
-
(1981)
Clin. Sci.
, vol.60
, pp. 319-326
-
-
Lundholm, K.1
Edstrom, S.2
Ekman, L.3
Karlberg, I.4
Walker, P.5
Schersten, T.6
-
58
-
-
0035966052
-
Hydrogen peroxide gnerated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes
-
Mahadev K., Wu X., Zilbering A., Zhu L., Lawrence J.T.R., Goldstein B.J. Hydrogen peroxide gnerated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes. J. Biol. Chem. 276:2001;48662-48669.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 48662-48669
-
-
Mahadev, K.1
Wu, X.2
Zilbering, A.3
Zhu, L.4
Lawrence, J.T.R.5
Goldstein, B.J.6
-
59
-
-
0141766912
-
Demography of dietary restriction and death in Drosophila
-
Mair W., Goymer P., Pletcher S.D., Partridge L. Demography of dietary restriction and death in Drosophila. Science. 301:2003;1731-1733.
-
(2003)
Science
, vol.301
, pp. 1731-1733
-
-
Mair, W.1
Goymer, P.2
Pletcher, S.D.3
Partridge, L.4
-
60
-
-
0025852359
-
Mechanisms of lipofuscinogenesis: Effect of the inhibition of lysosomal proteinases and lipases under varying concentrations of ambient oxygen in cultured rat neonatal myocardial cells
-
Marzabadi M.R., Sohal R.S., Brunk U.T. Mechanisms of lipofuscinogenesis: effect of the inhibition of lysosomal proteinases and lipases under varying concentrations of ambient oxygen in cultured rat neonatal myocardial cells. APMIS. 99:1991;416-426.
-
(1991)
APMIS
, vol.99
, pp. 416-426
-
-
Marzabadi, M.R.1
Sohal, R.S.2
Brunk, U.T.3
-
61
-
-
0036239678
-
Mitochondrial DNA deletion mutations. a causal role in sarcopenia
-
McKenzie D., Bua E., McKiernan S., Cao Z., Wanagat J., Aiken J.M. Mitochondrial DNA deletion mutations. A causal role in sarcopenia. Eur. J. Biochem. 269:2002;2010-2015.
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 2010-2015
-
-
McKenzie, D.1
Bua, E.2
McKiernan, S.3
Cao, Z.4
Wanagat, J.5
Aiken, J.M.6
-
62
-
-
0042691506
-
Autophagy genes are essential for dauer development and life-span extension in C. elegans
-
Melendez A., Talloczy Z., Seaman M., Eskelinen E.L., Hall D.H., Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science. 301:2003;1387-1391.
-
(2003)
Science
, vol.301
, pp. 1387-1391
-
-
Melendez, A.1
Talloczy, Z.2
Seaman, M.3
Eskelinen, E.L.4
Hall, D.H.5
Levine, B.6
-
63
-
-
0017834614
-
Spectrophotofluorometric and electron microscopic study of lipofuscin accumulation in the testis of aging mice
-
Miquel J., Lundgren P.R., Johnson J.E. Spectrophotofluorometric and electron microscopic study of lipofuscin accumulation in the testis of aging mice. J. Gerontol. 33:1978;5-19.
-
(1978)
J. Gerontol.
, vol.33
, pp. 5-19
-
-
Miquel, J.1
Lundgren, P.R.2
Johnson, J.E.3
-
64
-
-
0023065242
-
Intracellular protein catabolism and its control during nutrient deprivation and supply
-
Mortimore G.E., Pösö A.R. Intracellular protein catabolism and its control during nutrient deprivation and supply. Ann. Rev. Nutr. 7:1987;539-564.
-
(1987)
Ann. Rev. Nutr.
, vol.7
, pp. 539-564
-
-
Mortimore, G.E.1
Pösö, A.R.2
-
65
-
-
0025344161
-
Age-dependent production of mitochondrial hydrogen peroxide, lipid peroxides and fluorescent pigments in the rat heart
-
Muscari C., Caldarera C.M., Guarnieri C. Age-dependent production of mitochondrial hydrogen peroxide, lipid peroxides and fluorescent pigments in the rat heart. Basic Res. Cardiol. 85:1990;172-178.
-
(1990)
Basic Res. Cardiol.
, vol.85
, pp. 172-178
-
-
Muscari, C.1
Caldarera, C.M.2
Guarnieri, C.3
-
66
-
-
0032512636
-
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
-
Noda T., Ohsumi Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273:1998;3963-3966.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3963-3966
-
-
Noda, T.1
Ohsumi, Y.2
-
67
-
-
0029859045
-
Regulation of gene expression by insulin
-
O'Brien R.M., Granner D.K. Regulation of gene expression by insulin. Physiol. Rev. 76:1996;1109-1161.
-
(1996)
Physiol. Rev.
, vol.76
, pp. 1109-1161
-
-
O'Brien, R.M.1
Granner, D.K.2
-
68
-
-
0030822012
-
Control of the expression andactivity of the Ga-interacting protein (GAIP) in human intestinal cells
-
Ogier-Denis E., Petiot A., Bauvy C., Codogno P. Control of the expression andactivity of the Ga-interacting protein (GAIP) in human intestinal cells. J. Biol. Chem. 272:1997;24599-24603.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24599-24603
-
-
Ogier-Denis, E.1
Petiot, A.2
Bauvy, C.3
Codogno, P.4
-
69
-
-
0037705403
-
Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum
-
Otto G.P., Wu M.Y., Kazgan N., Anderson O.R., Kessin R.H. Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum. J. Biol. Chem. 278:2003;17636-17645.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 17636-17645
-
-
Otto, G.P.1
Wu, M.Y.2
Kazgan, N.3
Anderson, O.R.4
Kessin, R.H.5
-
70
-
-
0030897739
-
Genetic and functional changes in mitochondria associated with aging
-
Ozawa T. Genetic and functional changes in mitochondria associated with aging. Physiol. Rev. 77:1997;425-464.
-
(1997)
Physiol. Rev.
, vol.77
, pp. 425-464
-
-
Ozawa, T.1
-
71
-
-
0001437616
-
Bidirectional modulation of insulin action by amino acids
-
Patti M.-E., Brambilla E., Luzi L., Landaker E.J., Kahn C.R. Bidirectional modulation of insulin action by amino acids. J. Clin. Invest. 101:1998;1519-1529.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 1519-1529
-
-
Patti, M.-E.1
Brambilla, E.2
Luzi, L.3
Landaker, E.J.4
Kahn, C.R.5
-
72
-
-
0014618879
-
Amino acids across tissues of the forearm in post-absorptive man. Effects of insulin at two dose levels
-
Pozefsky T., Felig P., Tobin J.C., Soeldner J.S., Cahill G.F. Jr. Amino acids across tissues of the forearm in post-absorptive man. Effects of insulin at two dose levels. J. Clin. Invest. 48:1969;2273-2282.
-
(1969)
J. Clin. Invest.
, vol.48
, pp. 2273-2282
-
-
Pozefsky, T.1
Felig, P.2
Tobin, J.C.3
Soeldner, J.S.4
Cahill, G.F.Jr.5
-
73
-
-
0037452972
-
Implication of phosphatidylinositol 3-kinase membrane recruitment in hydrogen peroxide-induced activation of PI3K and Akt
-
Qin S., Chock P.B. Implication of phosphatidylinositol 3-kinase membrane recruitment in hydrogen peroxide-induced activation of PI3K and Akt. Biochemistry. 42:2003;2995-3003.
-
(2003)
Biochemistry
, vol.42
, pp. 2995-3003
-
-
Qin, S.1
Chock, P.B.2
-
75
-
-
0029116061
-
Oxidative damage to mitochondrial DNA and its relationship to ageing
-
Richter C. Oxidative damage to mitochondrial DNA and its relationship to ageing. Int. J. Biochem. Cell Biol. 27:1995;647-653.
-
(1995)
Int. J. Biochem. Cell Biol.
, vol.27
, pp. 647-653
-
-
Richter, C.1
-
77
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T., Hall M. TOR, a central controller of cell growth. Cell. 103:2000;253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.2
-
78
-
-
0019501619
-
Quantitative relationship between autophagy and proteolysis during graded amino acid deprivation in perfused rat liver
-
Schworer C.M., Shiffer K.A., Mortimore G.E. Quantitative relationship between autophagy and proteolysis during graded amino acid deprivation in perfused rat liver. J. Biol. Chem. 256:1981;7652-7658.
-
(1981)
J. Biol. Chem.
, vol.256
, pp. 7652-7658
-
-
Schworer, C.M.1
Shiffer, K.A.2
Mortimore, G.E.3
-
79
-
-
0026023219
-
Hydrogen peroxide release by mitochondria increases during aging
-
Sohal R.S., Sohal B.H. Hydrogen peroxide release by mitochondria increases during aging. Mech. Ageing Dev. 57:1991;187-202.
-
(1991)
Mech. Ageing Dev.
, vol.57
, pp. 187-202
-
-
Sohal, R.S.1
Sohal, B.H.2
-
80
-
-
0030038103
-
Oxidative stress, caloric restriction, and aging
-
Sohal R.S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 273:1996;59-63.
-
(1996)
Science
, vol.273
, pp. 59-63
-
-
Sohal, R.S.1
Weindruch, R.2
-
81
-
-
0032810282
-
The role of glucose, long-chain triglycerides and amino acids for promotion of amino acid balance across peripheral tissues in man
-
Svanberg E., Moller-Loswick A.C., Matthews D.E., Korner U., Andersson M., Lundholm K. The role of glucose, long-chain triglycerides and amino acids for promotion of amino acid balance across peripheral tissues in man. Clin. Physiol. 19:1999;311-320.
-
(1999)
Clin. Physiol.
, vol.19
, pp. 311-320
-
-
Svanberg, E.1
Moller-Loswick, A.C.2
Matthews, D.E.3
Korner, U.4
Andersson, M.5
Lundholm, K.6
-
82
-
-
0037039442
-
Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway
-
Tallóczy Z., Jiang W., Virgin H.W. IV, Leib D.A., Scheuner D., Kaufman R.J., Eskelinen E.-L., Levine B. Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway. Proc. Natl. Acad. Sci.: USA. 99:2002;190-195.
-
(2002)
Proc. Natl. Acad. Sci.: USA
, vol.99
, pp. 190-195
-
-
Tallóczy, Z.1
Jiang, W.2
Virgin IV, H.W.3
Leib, D.A.4
Scheuner, D.5
Kaufman, R.J.6
Eskelinen, E.-L.7
Levine, B.8
-
83
-
-
0035815445
-
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
-
Tatar M., Kopelman A., Epstein D., Tu M.P., Yin C.M., Garofalo R.S. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science. 292:2001;107-110.
-
(2001)
Science
, vol.292
, pp. 107-110
-
-
Tatar, M.1
Kopelman, A.2
Epstein, D.3
Tu, M.P.4
Yin, C.M.5
Garofalo, R.S.6
-
84
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
Tatar M., Bartke A., Antebi A. The endocrine regulation of aging by insulin-like signals. Science. 299:2003;1346-1351.
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
85
-
-
0029560552
-
The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
-
Terman A. The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes. Gerontol. 41(Suppl. 2):1995;319-326.
-
(1995)
Gerontol
, vol.41
, Issue.SUPPL. 2
, pp. 319-326
-
-
Terman, A.1
-
86
-
-
0042707790
-
Mitochondrial recycling and aging of cardiac myocytes: The role of autophagocytosis
-
Terman A., Dalen H., Eaton J.W., Neuzil J., Brunk U.T. Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis. Exp. Gerontol. 38:2003;863-876.
-
(2003)
Exp. Gerontol.
, vol.38
, pp. 863-876
-
-
Terman, A.1
Dalen, H.2
Eaton, J.W.3
Neuzil, J.4
Brunk, U.T.5
-
87
-
-
0022543887
-
Dose-response curves of effects of insulin on leucine kinetics in humans
-
Tessari P., Trevisan R., Inchiostro S., Biolo G., Nosadini R., De Kreutzenberg S.V., Duner E., Tiengo A., Crepaldi G. Dose-response curves of effects of insulin on leucine kinetics in humans. Am. J. Physiol. 251:1986;E334-E342.
-
(1986)
Am. J. Physiol.
, vol.251
, pp. 334-E342
-
-
Tessari, P.1
Trevisan, R.2
Inchiostro, S.3
Biolo, G.4
Nosadini, R.5
De Kreutzenberg, S.V.6
Duner, E.7
Tiengo, A.8
Crepaldi, G.9
-
88
-
-
0031935425
-
An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans
-
Tissenbaum H.A., Ruvkun G. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics. 148:1998;703-717.
-
(1998)
Genetics
, vol.148
, pp. 703-717
-
-
Tissenbaum, H.A.1
Ruvkun, G.2
-
89
-
-
0035826271
-
Increased dosage of a sir-2 gene extends life span in Caenorhabditis elegans
-
Tissenbaum H.A., Guarente L. Increased dosage of a sir-2 gene extends life span in Caenorhabditis elegans. Nature. 410:2001;227-230.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
90
-
-
0027424777
-
Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
-
Tsukada M., Ohsumi Y. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett. 333:1993;169-174.
-
(1993)
FEBS Lett.
, vol.333
, pp. 169-174
-
-
Tsukada, M.1
Ohsumi, Y.2
-
91
-
-
0013356701
-
The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico
-
Tu M.-P., Epstain D., Tatar M. The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico. Aging Cell. 1:2002;75-80.
-
(2002)
Aging Cell
, vol.1
, pp. 75-80
-
-
Tu, M.-P.1
Epstain, D.2
Tatar, M.3
-
92
-
-
0032080924
-
Exogenous amino acids stimulate net muscle protein synthesis in the elderly
-
Volpi E., Ferrando A.A., Yeckel C.W., Tipton K.D., Wolfe R.R. Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J. Clin. Invest. 101:1998;2000-2007.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 2000-2007
-
-
Volpi, E.1
Ferrando, A.A.2
Yeckel, C.W.3
Tipton, K.D.4
Wolfe, R.R.5
-
93
-
-
0038309329
-
The molecular mechanism of autophagy
-
Wang C.-W., Klionsky D.J. The molecular mechanism of autophagy. Mol. Med. 9:2003;65-76.
-
(2003)
Mol. Med.
, vol.9
, pp. 65-76
-
-
Wang, C.-W.1
Klionsky, D.J.2
-
94
-
-
0032528917
-
Amino acid availability regulates p70 S6 kinase and multiple translation factors
-
Wang X., Campbell L.E., Miller C.M., Proud C.G. Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochem. J. 334:1998;261-267.
-
(1998)
Biochem. J.
, vol.334
, pp. 261-267
-
-
Wang, X.1
Campbell, L.E.2
Miller, C.M.3
Proud, C.G.4
-
95
-
-
0029078415
-
Functional implication of autophagy in steroid-secreting cells of the rat
-
Yi J., Tang X.M. Functional implication of autophagy in steroid-secreting cells of the rat. Anatomic Rec. 242:1995;137-146.
-
(1995)
Anatomic Rec.
, vol.242
, pp. 137-146
-
-
Yi, J.1
Tang, X.M.2
-
96
-
-
0027730391
-
Formation of autophagosomes during degradation of excess peroxisomes induced by di-(2-ethylhexyl)phthalate treatment. II. Immunocytochemical analysis of early and late autophagosomes
-
Yokota S., Himeno M., Roth J., Brada D., Kato K. Formation of autophagosomes during degradation of excess peroxisomes induced by di-(2-ethylhexyl)phthalate treatment. II. Immunocytochemical analysis of early and late autophagosomes. Eur. J. Cell Biol. 62:1993;372-383.
-
(1993)
Eur. J. Cell Biol.
, vol.62
, pp. 372-383
-
-
Yokota, S.1
Himeno, M.2
Roth, J.3
Brada, D.4
Kato, K.5
|