Low fidelity DNA synthesis by a Y family DNA polymerase due to misalignment in the active site

Journal of Biological Chemistry

Volumn 277, Issue 22, 2002, Pages 19633-19638

  Kokoska, Robert J ^a   Bebenek, Katarzyna ^a   Boudsocq, François ^b   Woodgate, Roger ^a   Kunkel, Thomas A ^a,c  

^a Lab of Molecular Carcinogenesis   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; DNA; ENZYMES; MUTAGENESIS; SYNTHESIS (CHEMICAL);

BINDING POCKET;

BIOCHEMISTRY;

CYTOSINE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; DNA; DNA POLYMERASE; DNA POLYMERASE IV; EXONUCLEASE; GUANINE; THYMIDINE TRIPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BASE MISPAIRING; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA SYNTHESIS; ENZYME ACTIVE SITE; FRAMESHIFT MUTATION; GENE INSERTION; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SULFOLOBUS SOLFATARICUS;

BASE SEQUENCE; BINDING SITES; CYSTEINE; CYTOSINE; DNA POLYMERASE BETA; GENE DELETION; GUANINE; KINETICS; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE HOMOLOGY, NUCLEIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SULFOLOBUS;

INSERTION SEQUENCES; SULFOLOBUS; SULFOLOBUS SOLFATARICUS;

EID: 0037205402     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M202021200     Document Type: Article

References (43)