Functional humanization of an anti-CD30 Fab fragment for the immunotherapy of Hodgkin's lymphoma using an in vitro evolution approach

Protein Engineering, Design and Selection

Volumn 17, Issue 12, 2004, Pages 847-860

  Schlapschy, Martin ^a   Gruber, Helga ^a   Gresch, Oliver ^a   Schäfer, Claudia ^a   Renner, Christoph ^b   Pfreundschuh, Michael ^b   Skerra, Arne ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Affinity maturation; Antibody humanization; CD16; CD30; Hodgkin's lymphoma

Indexed keywords

BIOASSAY; ESCHERICHIA COLI; IMMUNOLOGY; LIVING SYSTEMS STUDIES; MONOCLONAL ANTIBODIES; MUTAGENESIS; OPTIMIZATION;

ANTIGEN-BINDING ACTIVITIES; IMMUNOGLOBULINS; IMMUNOTHERAPY; MUTATIONS;

ANTIGENS;

CANCER ANTIBODY; CD30 ANTIGEN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD30; RECOMBINANT ANTIGEN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBODY PRODUCTION; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CELL SPECIFICITY; COLONY FILTER SCREENING ASSAY; COMPLEMENTARITY DETERMINING REGION; CONSENSUS SEQUENCE; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FLUORESCENCE ACTIVATED CELL SORTING; HODGKIN DISEASE; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOGLOBULIN VARIABLE REGION; IN VITRO STUDY; INDUCED MUTATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN DOMAIN; SATURATION MUTAGENESIS; TECHNIQUE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD30; BASE SEQUENCE; CELL LINE, TUMOR; CELL SEPARATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FLOW CYTOMETRY; HODGKIN DISEASE; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOTHERAPY; KINETICS; MICE; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUTAGENESIS; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, IGG; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; TIME FACTORS;

ESCHERICHIA COLI; PHRAGMITES;

EID: 15344341215     PISSN: 17410126     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/gzh098     Document Type: Article

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