Humanization of a mouse monoclonal antibody that blocks the epidermal growth factor receptor: Recovery of antagonistic activity

Immunotechnology

Volumn 3, Issue 1, 1997, Pages 71-81

  Mateo, Cristina ^a   Moreno, Ernesto ^a,c   Amour, Kathryn ^b   Lombardero, Josefa ^a   Harris, William ^b   Pérez, Rolando ^a  

^a CENTER OF MOLECULAR IMMUNOLOGY   (Cuba)

^b Aberdeen Sci and Technol Park   (United Kingdom)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Antibody humanization; CDR grafting; EGF receptor; Molecular modelling

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY;

ANTIBODY STRUCTURE; ARTICLE; BINDING AFFINITY; CERCOPITHECIDAE; COMPLEMENTARITY DETERMINING REGION; HUMAN; IMMUNE SYSTEM; MOLECULAR MODEL; MOUSE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CLONING, MOLECULAR; EPIDERMAL GROWTH FACTOR; GENETIC ENGINEERING; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, NUDE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS;

EID: 0030910482     PISSN: 13802933     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1380-2933(97)00065-1     Document Type: Article

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