Role of c-Kit and erythropoietin receptor in erythropoiesis

Critical Reviews in Oncology/Hematology

Volumn 54, Issue 1, 2005, Pages 63-75

  Munugalavadla, Veerendra ^a   Kapur, Reuben ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

c Kit; Epo; Epo R; SCF; Signal transduction

Indexed keywords

ERYTHROPOIETIN RECEPTOR; PROTEIN TYROSINE KINASE; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT STEM CELL FACTOR; STEM CELL FACTOR;

ANEMIA; BREAST CARCINOMA; CELL DIFFERENTIATION; CELL VIABILITY; CLINICAL TRIAL; ERYTHROPOIESIS; GENE MUTATION; GENETIC CODE; HUMAN; LIVER; LYMPHOMA; MACROCYTIC ANEMIA; MYELOMA; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

EID: 15244362782     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2004.11.005     Document Type: Review

References (132)

1. C.S. Lin, S.K. Lim, V. D'Agati, and F. Costantini Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis Genes Dev 10 1996 154 164
2. H. Wu, X. Liu, R. Jaenisch, and H.F. Lodish Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor Cell 83 1995 59 67
3. S.B. Krantz Erythropoietin Blood 77 1991 419 434
4. K. Nocka, S. Majumder, and B. Chabot Expression of c-Kit gene products in known cellular targets of W mutations in normal and W mutant mice - evidence for an impaired c-Kit kinase in mutant mice Genes Dev 3 1989 816 826
5. E.S. Russell Hereditary anemias of the mouse: a review for geneticists Adv Genet 20 1979 357 459
6. V.C. Broudy Stem cell factor and hematopoiesis Blood 90 1997 1345 1364
7. S.J. Galli, K.M. Zsebo, and E.N. Geissler The Kit ligand, stem cell factor Adv Immunol 55 1994 1 96
8. B. Chabot, D.A. Stephenson, V.M. Chapman, P. Besmer, and A. Bernstein The proto-oncogene c-Kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus Nature 335 1988 88 89
9. E.N. Geissler, S.V. Cheng, J.F. Gusella, and D.E. Housman Genetic analysis of the dominant white-spotting (W) region on mouse chromosome 5: identification of cloned DNA markers near W Proc Natl Acad Sci USA 85 1988 9635 9639
10. E.N. Geissler, M.A. Ryan, and D.E. Housman The dominant-white spotting (W) locus of the mouse encodes the c-Kit proto-oncogene Cell 55 1988 185 192
11. N.G. Copeland, D.J. Gilbert, and B.C. Cho Mast cell growth factor maps near the Steel locus on mouse chromosome 10 and is deleted in a number of steel alleles Cell 63 1990 175 183
12. J.G. Flanagan, and P. Leder The Kit ligand: a cell surface molecule altered in steel mutant fibroblasts Cell 63 1990 185 194
13. E. Huang, K. Nocka, and D.R. Beier The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-Kit receptor, the gene product of the W locus Cell 63 1990 225 233
14. K.M. Zsebo, D.A. Williams, and E.N. Geissler Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-Kit tyrosine kinase receptor Cell 63 1990 213 224
15. K.M. Zsebo, J. Wypych, and I.K. McNiece Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver - conditioned medium Cell 63 1990 195 201
16. E.N. Geissler, E.C. McFarland, and E.S. Russell Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: a description of ten new W alleles Genetics 97 1981 337 361
17. K. Nocka, J.C. Tan, and E. Chiu Molecular bases of dominant negative and loss of function mutations at the murine c-Kit/white spotting locus: W37, Wv, W41 and W EMBO J 9 1990 1805 1813
18. A.D. Reith, R. Rottapel, E. Giddens, C. Brady, L. Forrester, and A. Bernstein W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-Kit receptor Genes Dev 4 1990 390 400
19. D.M. Anderson, S.D. Lyman, and A. Baird Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms Cell 63 1990 235 243
20. C.I. Brannan, S.D. Lyman, and D.E. Williams Steel-dickie mutation encodes a c-Kit ligand lacking transmembrane and cytoplasmic domains Proc Natl Acad Sci USA 88 1991 4671 4674
21. J.G. Flanagan, D.C. Chan, and P. Leder Transmembrane form of the Kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant Cell 64 1991 1025 1035
22. E.J. Huang, K.H. Nocka, J. Buck, and P. Besmer Differential expression and processing of two cell associated forms of the Kit-ligand: KL-1 and KL-2 Mol Biol Cell 3 1992 349 362
23. F.H. Martin, S.V. Suggs, and K.E. Langley Primary structure and functional expression of rat and human stem cell factor DNAs Cell 63 1990 203 211
24. D. Toksoz, K.M. Zsebo, and K.A. Smith Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor Proc Natl Acad Sci USA 89 1992 7350 7354
25. M.K. Majumdar, L. Feng, E. Medlock, D. Toksoz, and D.A. Williams Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor cDNA yields biologically active, cell-associated protein J Biol Chem 269 1994 1237 1242
26. C.I. Brannan, M.A. Bedell, and J.L. Resnick Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail Genes Dev 6 1992 1832 1842
27. R. Kapur, R. Cooper, X. Xiao, M.J. Weiss, P. Donovan, and D.A. Williams The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel(17H) mice Blood 94 1999 1915 1925
28. R. Kapur, M. Majumdar, X. Xiao, M. McAndrews-Hill, K. Schindler, and D.A. Williams Signaling through the interaction of membrane-restricted stem cell factor and c-Kit receptor tyrosine kinase: genetic evidence for a differential role in erythropoiesis Blood 91 1998 879 889
29. Y. Tajima, E.J. Huang, K. Vosseller, M. Ono, M.A. Moore, and P. Besmer Role of dimerization of the membrane-associated growth factor Kit ligand in juxtacrine signaling: the Sl17H mutation affects dimerization and stability-phenotypes in hematopoiesis J Exp Med 187 1998 1451 1461
30. Y. Tajima, M.A. Moore, V. Soares, M. Ono, H. Kissel, and P. Besmer Consequences of exclusive expression in vivo of Kit-ligand lacking the major proteolytic cleavage site Proc Natl Acad Sci USA 95 1998 11903 11908
31. K. Miyazawa, D.A. Williams, A. Gotoh, J. Nishimaki, H.E. Broxmeyer, and K. Toyama Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-Kit gene-encoded protein than its soluble form Blood 85 1995 641 649
32. R. Kapur, S. Chandra, R. Cooper, J. McCarthy, and D.A. Williams Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor Blood 100 2002 1287 1293
33. M. Boissan, F. Feger, J.J. Guillosson, and M. Arock c-Kit and c-Kit mutations in mastocytosis and other hematological diseases J Leukoc Biol 67 2000 135 148
34. J.L. Gommerman, D. Sittaro, N.Z. Klebasz, D.A. Williams, and S.A. Berger Differential stimulation of c-Kit mutants by membrane-bound and soluble Steel Factor correlates with leukemic potential Blood 96 2000 3734 3742
35. J. Lennartsson, P. Blume-Jensen, M. Hermanson, E. Ponten, M. Carlberg, and L. Ronnstrand Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-Kit mediated activation of the Ras/MAP kinase pathway and c-fos induction Oncogene 18 1999 5546 5553
36. D. Linnekin Early signaling pathways activated by c-Kit in hematopoietic cells Int J Biochem Cell Biol 31 1999 1053 1074
37. D. Linnekin, C.S. DeBerry, and S. Mou Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells J Biol Chem 272 1997 27450 27455
38. H. Serve, N.S. Yee, G. Stella, L. Sepp-Lorenzino, J.C. Tan, and P. Besmer Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells EMBO J 14 1995 473 483
39. K. Thommes, J. Lennartsson, M. Carlberg, and L. Ronnstrand Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor Biochem J 341 1999 211 216
40. I. Timokhina, H. Kissel, G. Stella, and P. Besmer Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation EMBO J 17 1998 6250 6262
41. S. Ueda, M. Mizuki, and H. Ikeda Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration Blood 99 2002 3342 3349
42. R.L. Cutler, L. Liu, J.E. Damen, and G. Krystal Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells J Biol Chem 268 1993 21463 21465
43. V. Duronio, M.J. Welham, S. Abraham, P. Dryden, and J.W. Schrader p21ras activation via hemopoietic receptors and c-Kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein Proc Natl Acad Sci USA 89 1992 1587 1591
44. T. Jahn, P. Seipel, S. Urschel, C. Peschel, and J. Duyster Role for the adaptor protein Grb10 in the activation of Akt Mol Cell Biol 22 2002 979 991
45. M. Sattler, R. Salgia, and G. Shrikhande Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-Kit, phosphatidylinositol 3-kinase, and p120(CBL) J Biol Chem 272 1997 10248 10253
46. T.B. van Dijk, E. van Den Akker, M.P. Amelsvoort, H. Mano, B. Lowenberg, and M. von Lindern Stem cell factor induces phosphatidylinositol 3′-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells Blood 96 2000 3406 3413
47. M. Kozlowski, L. Larose, F. Lee, D.M. Le, R. Rottapel, and K.A. Siminovitch SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain Mol Cell Biol 18 1998 2089 2099
48. U. Lorenz, A.D. Bergemann, and H.N. Steinberg Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1 J Exp Med 184 1996 1111 1126
49. T. Tauchi, G.S. Feng, and M.S. Marshall The ubiquitously expressed Syp phosphatase interacts with c-Kit and Grb2 in hematopoietic cells J Biol Chem 269 1994 25206 25211
50. M. Huber, C.D. Helgason, J.E. Damen, L. Liu, R.K. Humphries, and G. Krystal The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation Proc Natl Acad Sci USA 95 1998 11330 11335
51. B.L. Tan, M.N. Yazicioglu, and D. Ingram Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells Blood 101 2003 4725 4732
52. F.C. Yang, R. Kapur, and A.J. King Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells Immunity 12 2000 557 568
53. T. Fukao, T. Yamada, and M. Tanabe Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice Nat Immunol 3 2002 295 304
54. H. Huddleston, B. Tan, and F.C. Yang Functional p85alpha gene is required for normal murine fetal erythropoiesis Blood 102 2003 142 145
55. T. Gregory, C. Yu, A. Ma, S.H. Orkin, G.A. Blobel, and M.J. Weiss GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression Blood 94 1999 87 96
56. M.J. Weiss, C. Yu, and S.H. Orkin Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line Mol Cell Biol 17 1997 1642 1651
57. R. Kapur, R. Cooper, L. Zhang, and D.A. Williams Cross-talk between alpha(4)beta(1)/alpha(5)beta(1) and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways Blood 97 2001 1975 1981
58. R. Kapur, and L. Zhang A novel mechanism of cooperation between c-Kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin J Biol Chem 276 2001 1099 1106
59. B.L. Tan, L. Hong, V. Munugalavadla, and R. Kapur Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor J Biol Chem 278 2003 11686 11695
60. Y. Kimura, N. Jones, and M. Kluppel Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages Proc Natl Acad Sci USA 101 2004 6015 6020
61. P. Blume-Jensen, G. Jiang, R. Hyman, K.F. Lee, S. O'Gorman, and T. Hunter Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility Nat Genet 24 2000 157 162
62. H. Kissel, I. Timokhina, and M.P. Hardy Point mutation in Kit receptor tyrosine kinase reveals essential roles for Kit signaling in spermatogenesis and oogenesis without affecting other Kit responses EMBO J 19 2000 1312 1326
63. L. Hong, V. Munugalavadla, and R. Kapur c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways Mol Cell Biol 24 2004 1401 1410
64. M.C. Heinrich, C.D. Blanke, B.J. Druker, and C.L. Corless Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies J Clin Oncol 20 2002 1692 1703
65. N. Jiang, T.C. He, A. Miyajima, and D.M. Wojchowski The box1 domain of the erythropoietin receptor specifies Janus kinase 2 activation and functions mitogenically within an interleukin 2 beta-receptor chimera J Biol Chem 271 1996 16472 16476
66. B.A. Witthuhn, F.W. Quelle, and O. Silvennoinen JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin Cell 74 1993 227 236
67. U. Klingmuller The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells - signals emanating from the erythropoietin receptor Eur J Biochem 249 1997 637 647
68. D.M. Wojchowski, R.C. Gregory, C.P. Miller, A.K. Pandit, and T.J. Pircher Signal transduction in the erythropoietin receptor system Exp Cell Res 253 1999 143 156
69. U. Klingmuller, H. Wu, and J.G. Hsiao Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors Proc Natl Acad Sci USA 94 1997 3016 3021
70. C.P. Miller, D.W. Heilman, and D.M. Wojchowski Erythropoietin receptor-dependent erythroid colony-forming unit development: capacities of Y343 and phosphotyrosine-null receptor forms Blood 99 2002 898 904
71. H. Zang, K. Sato, H. Nakajima, C. McKay, P.A. Ney, and J.N. Ihle The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis EMBO J 20 2001 3156 3166
72. S. Uddin, S. Kottegoda, D. Stigger, L.C. Platanias, and A. Wickrema Activation of the Akt/FKHRL1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors Biochem Biophys Res Commun 275 2000 16 19
73. T.J. Pircher, J.N. Geiger, D. Zhang, C.P. Miller, P. Gaines, and D.M. Wojchowski Integrative signaling by minimal erythropoietin receptor forms and c-Kit J Biol Chem 276 2001 8995 9002
74. M. Socolovsky, A.E. Fallon, S. Wang, C. Brugnara, and H.F. Lodish Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction Cell 98 1999 181 191
75. N. Motoyama, T. Kimura, T. Takahashi, T. Watanabe, and T. Nakano bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation J Exp Med 189 1999 1691 1698
76. F.W. Quelle, D. Wang, and T. Nosaka Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response Mol Cell Biol 16 1996 1622 1631
77. F.W. Quelle, J. Wang, and J. Feng Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways Genes Dev 12 1998 1099 1107
78. J.E. Damen, L. Liu, and H. Wakao The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation Leukemia 11 Suppl. 3 1997 423 425
79. J.E. Damen, H. Wakao, and A. Miyajima Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation EMBO J 14 1995 5557 5568
80. S. Gobert, F. Porteu, and S. Pallu Tyrosine phosphorylation of the erythropoietin receptor: role for differentiation and mitogenic signal transduction Blood 86 1995 598 606
81. S. Gobert, S. Chretien, and F. Gouilleux Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation EMBO J 15 1996 2434 2441
82. R.C. Gregory, N. Jiang, K. Todokoro, J. Crouse, R.E. Pacifici, and D.M. Wojchowski Erythropoietin receptor and STAT5-specific pathways promote SKT6 cell hemoglobinization Blood 92 1998 1104 1118
83. K. Iwatsuki, T. Endo, and H. Misawa STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line J Biol Chem 272 1997 8149 8152
84. A.D. D'Andrea, A. Yoshimura, H. Youssoufian, L.I. Zon, J.W. Koo, and H.F. Lodish The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains Mol Cell Biol 11 1991 1980 1987
85. M.O. Arcasoy, B.A. Degar, K.W. Harris, and B.G. Forget Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene Blood 89 1997 4628 4635
86. A. de la Chapelle, P. Sistonen, H. Lehvaslaiho, E. Ikkala, and E. Juvonen Familial erythrocytosis genetically linked to erythropoietin receptor gene Lancet 341 1993 82 84
87. A. de la Chapelle, A.L. Traskelin, and E. Juvonen Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis Proc Natl Acad Sci USA 90 1993 4495 4499
88. L. Sokol, M. Luhovy, Y. Guan, J.F. Prchal, G.L. Semenza, and J.T. Prchal Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin Blood 86 1995 15 22
89. K. Li, M.P. Menon, V.G. Karur, S. Hegde, and D.M. Wojchowski Attenuated signaling by a phosphotyrosine-null Epo receptor form in primary erythroid progenitor cells Blood 102 2003 3147 3153
90. T. Yi, J. Zhang, O. Miura, and J.N. Ihle Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites Blood 85 1995 87 95
91. L.D. Shultz, P.A. Schweitzer, and T.V. Rajan Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene Cell 73 1993 1445 1454
92. Y. Kubota, T. Tanaka, and A. Kitanaka Src transduces erythropoietin- induced differentiation signals through phosphatidylinositol 3-kinase EMBO J 20 2001 5666 5677
93. C. Boudot, Z. Kadri, and E. Petitfrere Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells Cell Signal 14 2002 869 878
94. C. Boudot, E. Dasse, and E. Lambert Involvement of the Src kinase Lyn in phospholipase C-gamma 2 phosphorylation and phosphatidylinositol 3-kinase activation in Epo signalling Biochem Biophys Res Commun 300 2003 437 442
95. I. Dusanter-Fourt, N. Casadevall, and C. Lacombe Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin- responsive cells J Biol Chem 267 1992 10670 10675
96. D. Linnekin, G.A. Evans, A. D'Andrea, and W.L. Farrar Association of the erythropoietin receptor with protein tyrosine kinase activity Proc Natl Acad Sci USA 89 1992 6237 6241
97. O. Miura, A. D'Andrea, D. Kabat, and J.N. Ihle Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis Mol Cell Biol 11 1991 4895 4902
98. F.W. Quelle, and D.M. Wojchowski Proliferative action of erythropoietin is associated with rapid protein tyrosine phosphorylation in responsive B6SUt.EP cells J Biol Chem 266 1991 609 614
99. U. Klingmuller, U. Lorenz, L.C. Cantley, B.G. Neel, and H.F. Lodish Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals Cell 80 1995 729 738
100. G. Van Zant, and L. Shultz Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev) Exp Hematol 17 1989 81 87
101. R. Starr, T.A. Willson, and E.M. Viney A family of cytokine-inducible inhibitors of signalling Nature 387 1997 917 921
102. A. Yoshimura, T. Ohkubo, and T. Kiguchi A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors EMBO J 14 1995 2816 2826
103. A. Matsumoto, M. Masuhara, and K. Mitsui CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation Blood 89 1997 3148 3154
104. F. Verdier, R. Rabionet, and F. Gouilleux A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B Mol Cell Biol 18 1998 5852 5860
105. T.A. Endo, M. Masuhara, and M. Yokouchi A new protein containing an SH2 domain that inhibits JAK kinases Nature 387 1997 921 924
106. T. Naka, M. Narazaki, and M. Hirata Structure and function of a new STAT-induced STAT inhibitor Nature 387 1997 924 929
107. N.A. Cacalano, D. Sanden, and J.A. Johnston Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras Nat Cell Biol 3 2001 460 465
108. S.J. Cohney, D. Sanden, and N.A. Cacalano SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation Mol Cell Biol 19 1999 4980 4988
109. A. Sasaki, H. Yasukawa, T. Shouda, T. Kitamura, I. Dikic, and A. Yoshimura CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2 J Biol Chem 275 2000 29338 29347
110. J.C. Marine, D.J. Topham, and C. McKay SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality Cell 98 1999 609 616
111. D. Metcalf, W.S. Alexander, and A.G. Elefanty Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1 Leukemia 13 1999 926 934
112. M.K. Sarna, E. Ingley, and S.J. Busfield Differential regulation of SOCS genes in normal and transformed erythroid cells Oncogene 22 2003 3221 3230
113. H. Wu, U. Klingmuller, P. Besmer, and H.F. Lodish Interaction of the erythropoietin and stem-cell-factor receptors Nature 377 1995 242 246
114. H. Wu, U. Klingmuller, A. Acurio, J.G. Hsiao, and H.F. Lodish Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation Proc Natl Acad Sci USA 94 1997 1806 1810
115. K. Li, C. Miller, S. Hegde, and D. Wojchowski Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with Kit J Biol Chem 278 2003 40702 40709
116. X. Sui, S.B. Krantz, M. You, and Z. Zhao Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis Blood 92 1998 1142 1149
117. T. Sato, S. Watanabe, E. Ishii, K. Tsuji, and T. Nakahata Induction of the erythropoietin receptor gene and acquisition of responsiveness to erythropoietin by stem cell factor in HML/SE, a human leukemic cell line J Biol Chem 273 1998 16921 16926
118. A.K. Boer, A.L. Drayer, and E. Vellenga Stem cell factor enhances erythropoietin-mediated transactivation of signal transducer and activator of transcription 5 (STAT5) via the PKA/CREB pathway Exp Hematol 31 2003 512 520
119. M. Von Lindern, U. Schmidt, and H. Beug Control of erythropoiesis by erythropoietin and stem cell factor: a novel role for Bruton's tyrosine kinase Cell Cycle 2004 3
120. E. Ferrario, L. Ferrari, and P. Bidoli Treatment of cancer-related anemia with epoetin alfa: a review Cancer Treat Rev 30 2004 563 575
121. T. Coleman, and M. Brines Science review: recombinant human erythropoietin in critical illness: a role beyond anemia? Crit Care 8 2004 337 341
122. R. Provenzano, L. Garcia-Mayol, and P. Suchinda Once-weekly epoetin alfa for treating the anemia of chronic kidney disease Clin Nephrol 61 2004 392 405
123. D.T. Dieterich, R. Wasserman, and N. Brau Once-weekly epoetin alfa improves anemia and facilitates maintenance of ribavirin dosing in hepatitis C virus-infected patients receiving ribavirin plus interferon alfa Am J Gastroenterol 98 2003 2491 2499
124. A. Dev, K. Patel, A. Muir, and J.G. McHutchison Erythropoietin for ribavirin-induced anemia in hepatitis C: more answers but many more questions Am J Gastroenterol 98 2003 2344 2347
125. A.E. Gergely, P. Lafarge, I. Fouchard-Hubert, and F. Lunel-Fabiani Treatment of ribavirin/interferon-induced anemia with erythropoietin in patients with hepatitis C Hepatology 35 2002 1281 1282
126. S. Genc, T.F. Koroglu, and K. Genc Erythropoietin and the nervous system Brain Res 1000 2004 19 31
127. W. Jelkmann, and K. Wagner Beneficial and ominous aspects of the pleiotropic action of erythropoietin Ann Hematol 83 2004 673 686
128. M.J. Weiss New insights into erythropoietin and epoetin alfa: mechanisms of action, target tissues, and clinical applications Oncologist 8 Suppl. 3 2003 18 29
129. D.H. Henry The evolving role of epoetin alfa in cancer therapy Oncologist 9 2004 97 107
130. C.L. Yao, I.M. Chu, T.B. Hsieh, and S.M. Hwang A systematic strategy to optimize ex vivo expansion medium for human hematopoietic stem cells derived from umbilical cord blood mononuclear cells Exp Hematol 32 2004 720 727
131. I.H. Chin-Yee, M. Keeney, and A.K. Stewart Optimising parameters for peripheral blood leukapheresis after r-metHuG-CSF (filgrastim) and r-metHuSCF (ancestim) in patients with multiple myeloma: a temporal analysis of CD34(+) absolute counts and subsets Bone Marrow Transplant 30 2002 851 860
132. P. Menedez, F. Prosper, and C. Bueno Sequential analysis of CD34+ and CD34- cell subsets in peripheral blood and leukapheresis products from breast cancer patients mobilized with SCF plus G-CSF and cyclophosphamide Leukemia 15 2001 430 439