Stem cell factor enhances erythropoietin-mediated transactivation of signal transducer and activator of transcription 5 (STAT5) via the PKA/CREB pathway

Experimental Hematology

Volumn 31, Issue 6, 2003, Pages 512-520

  Boer, Arjen Kars ^a   Drayer, A Lyndsay ^a,b   Vellenga, Edo ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b Sanquin Bloedbank Regio Nordoost Groningen   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 6,7 DIMETHOXY 2 PHENYLQUINOXALINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DNA; ERYTHROPOIETIN; INHIBITOR PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN INHIBITOR; PROTEIN P300; SERINE; STAT5 PROTEIN; STEM CELL FACTOR; TYROSINE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; CONTROLLED STUDY; ERYTHROID CELL; ERYTHROPOIESIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSACTIVATION;

EID: 0037711691     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(03)00075-4     Document Type: Conference Paper

References (47)

1. Panzenbock B., Bartunek P., Mapara M.Y., Zenke M. Growth and differentiation of human stem cell factor/erythropoietin-dependent erythroid progenitor cells in vitro. Blood. 92:1998;3658-3688.
2. Wu H., Klingmuller U., Acurio A., Hsiao J.G., Lodish H.F. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. Proc Natl Acad Sci USA. 94:1997;1806-1810.
3. Olweus J., Terstappen L.W., Thompson P.A., Lund-Johansen F. Expression and function of receptors for stem cell factor and erythropoietin during lineage commitment of human hematopoietic progenitor cells. Blood. 88:1996;1594-1667.
4. - sorted bone marrow cells of myelodysplasia patients. Blood. 88:1996;505-510.
5. Chui D., Liao S., Walker K. Fetal erythropoiesis in Steel mutant mice III. Defect in differentiation and proliferation of hematopoietic stem cells . Blood. 51:1978;539-550.
6. Nocka K., Majumder S., Chabot B., et al. Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice - evidence for an impaired c-kit kinase in mutant mice. Genes Dev. 3:1989;816-826.
7. Russell E.S. Hereditary anemias of the mouse: a review for geneticists. Adv Genet. 20:1979;357-459.
8. Wu H., Liu X., Jaenisch R., Lodish H.F. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell. 83:1995;59-67.
9. Sui X., Krantz S.B., You M., Zhao Z. Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis. Blood. 92:1998;1142-1149.
10. Sui X., Krantz S.B., Zhao Z.J. Stem cell factor and erythropoietin inhibit apoptosis of human erythroid progenitor cells through different signalling pathways. Br J Haematol. 110:2000;63-70.
11. Wu H., Klingmuller U., Besmer P., Lodish H.F. Interaction of the erythropoietin and stem-cell-factor receptors. Nature. 377:1995;242-246.
12. Jacobs-Helber S.M., Penta K., Sun Z., Lawson A., Sawyer S.T. Distinct signaling from stem cell factor and erythropoietin in HCD57 cells. J Biol Chem. 272:1997;6850-6853.
13. Pallard C., Gouilleux F., Benit L., et al. Thrombopoietin activates a STAT5-like factor in hematopoietic cells. EMBO J. 14:1995;2847-2856.
14. Mellitzer G., Wessely O., Decker T., Meinke A., Hayman M.J., Beug H. Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation. Proc Natl Acad Sci USA. 93:1996;9600-9605.
15. Nosaka T., Kawashima T., Misawa K., Ikuta K., Mui A.L., Kitamura T. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J. 18:1999;4754-4765.
16. Snow J.W., Abraham N., Ma M.C., Abbey N.W., Herndier B., Goldsmith M.A. STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells. Blood. 99:2002;95-101.
17. -/- mice due to decreased survival of early erythroblasts. Blood. 98:2001;3261-3273.
18. -/- mice: a direct role for Stat5 in bcl-XL induction. Cell. 98:1999;181-191.
19. Liu X., Robinson G.W., Gouilleux F., Groner B., Hennighausen L. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci USA. 92:1995;8831-8835.
20. Azam M., Erdjument-Bromage H., Kreider B.L., et al. Interleukin-3 signals through multiple isoforms of Stat5. EMBO J. 14:1995;1402-1411.
21. Beuvink I., Hess D., Flotow H., Hofsteenge J., Groner B., Hynes N.E. Stat5a serine phosphorylation. Serine 779 is constitutively phosphorylated in the mammary gland, and serine 725 phosphorylation influences prolactin-stimulated in vitro DNA binding activity. J Biol Chem. 275:2000;10247-10255.
22. Yamashita H., Xu J., Erwin R.A., Farrar W.L., Kirken R.A., Rui H. Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells. J Biol Chem. 273:1998;30218-30224.
23. 2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB. Blood. 100:2002;467-473.
24. Yamashita H., Nevalainen M.T., Xu J., et al. Role of serine phosphorylation of Stat5a in prolactin-stimulated β-casein gene expression. Mol Cell Endocrinol. 183:2001;151-153.
25. Brizzi M.F., Dentelli P., Rosso A., Yarden Y., Pegoraro L. STAT protein recruitment and activation in c-kit deletion mutants. J Biol Chem. 274:1999;16965-16972.
26. Ryan J.J., Huang H., McReynolds L.J., et al. Stem cell factor activates STAT-5 DNA binding in IL-3-derived bone marrow mast cells. Exp Hematol. 25:1997;357-362.
27. Matsumura I., Nakajima K., Wakao H., et al. Involvement of prolonged ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell line. Mol Cell Biol. 18:1998;4282-4290.
28. Kwok R.P., Lundblad J.R., Chrivia J.C., et al. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature. 370:1994;223-226.
29. Day R.N., Walder J.A., Maurer R.A. A protein kinase inhibitor gene reduces both basal and multihormone-stimulated prolactin gene transcription. J Biol Chem. 264:1989;431-436.
30. Bannister A.J., Kouzarides T. CBP-induced stimulation of c-Fos activity is abrogated by E1A. EMBO J. 14:1995;4758-4762.
31. Shaywitz A.J., Dove S.L., Kornhauser J.M., Hochschild A., Greenberg M.E. Magnitude of the CREB-dependent transcriptional response is determined by the strength of the interaction between the kinase-inducible domain of CREB and the KIX domain of CREB-binding protein. Mol Cell Biol. 20:2000;9409-9422.
32. Miyazaki Y., Kuriyama K., Higuchi M., et al. Establishment and characterization of a new erythropoietin-dependent acute myeloid leukemia cell line, AS-E2. Leukemia. 11:1997;1941-1949.
33. Wiley J.C., Wailes L.A., Idzerda R.L., McKnight G.S. Role of regulatory subunits and protein kinase inhibitor (PKI) in determining nuclear localization and activity of the catalytic subunit of protein kinase A. J Biol Chem. 274:1999;6381-6387.
34. Pfitzner E., Jahne R., Wissler M., Stoecklin E., Groner B. p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response. Mol Endocrinol. 12:1998;1582-1593.
35. Kapur R., Zhang L. A novel mechanism of cooperation between c-kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin. J Biol Chem. 276:2001;1099-1106.
36. Erickson-Miller C.L., Pelus L.M., Lord K.A. Signaling induced by erythropoietin and stem cell factor in UT-7/Epo cells: transient vs sustained proliferation. Stem Cells. 18:2000;366-373.
37. Kung A.L., Rebel V.I., Bronson R.T., et al. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 14:2000;272-277.
38. Zhu M., John S., Berg M., Leonard W.J. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNγ-mediated signaling. Cell. 96:1999;121-130.
39. Cardinaux J.R., Notis J.C., Zhang Q., et al. Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation. Mol Cell Biol. 20:2000;1546-1552.
40. Masuoka H.C., Townes T.M. Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood. 99:2002;736-745.
41. Kasper L., Boussouar F., Ney P., et al. Normal hematopoiesis in mice requires the CREB- and c-Myb-binding surface of the transcriptional coactivator p300. [abstract] Keystone Symposia Abstract Book Hematopoiesis. 68:2001;E3. Abstract 68.
42. Price E.R., Ding H.F., Badalian T., et al. Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia. J Biol Chem. 273:1998;17983-17986.
43. Bohm M., Moellmann G., Cheng E., et al. Identification of p90RSK as the probable CREB-Ser133 kinase in human melanocytes. Cell Growth Differ. 6:1995;291-302.
44. Kadonaga J.T. Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines. Cell. 92:1998;307-313.
45. Zhang W., Kadam S., Emerson B.M., Bieker J.J. Site-specific acetylation by p300 or CREB binding protein regulates erythroid Kruppel-like factor transcriptional activity via its interaction with the SWI-SNF complex. Mol Cell Biol. 21:2001;2413-2422.
46. Doppler W., Windegger M., Soratroi C., et al. Expression level-dependent contribution of glucocorticoid receptor domains for functional interaction with stat5. Mol Cell Biol. 21:2001;3266-3279.
47. Mahmud D.L., Amlak M., Deb D.K., Platanias L.C., Uddin S., Wickrema A. Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene. 21:2002;1556-1562.