Erythropoietin receptor-dependent erythroid colony-forming unit development: Capacities of Y343 and phosphotyrosine-null receptor forms

Blood

Volumn 99, Issue 3, 2002, Pages 898-904

  Miller, Chris P ^a   Heilman, Destin W ^a   Wojchowski, Don M ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; JANUS KINASE; PHOSPHOTYROSINE; STAT5 PROTEIN; THIAMPHENICOL; TRANSCRIPTION FACTOR GATA 1;

ANIMAL CELL; ARTICLE; CELL MATURATION; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME ACTIVATION; ERYTHROCYTE; ERYTHROPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STEM CELL; TRANSGENIC MOUSE;

EID: 0036464667     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.3.898     Document Type: Article

References (51)

1. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
2. Regulation of the erythropoietin gene
3. Human marrow cells capable of erythropoietic differentiation in vitro: Definition of three erythroid colony responses
4. EPOetin alfa: Into the new millennium
5. Structural design and molecular evolution of a cytokine receptor superfamily
6. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
7. The box1 domain of the erythropoietin receptor specifies Janus kinase 2 activation and functions mitogenically within an interleukin 2 beta-receptor chimera
8. The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells - Signals emanating from the erythropoietin receptor
9. Signal transduction in the erythropoietin receptor system
10. The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor
11. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
12. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors
13. The prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitors
14. A minimal cytoplasmic subdomain of the erythropoietin receptor mediates erythroid and megakaryocytic cell development
15. Activation of the Akt/FKHRL1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors
16. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/-mice: A direct role for Stat5 in (Bcl-XL) induction
17. Integrative signaling by minimal erythropoietin receptor forms and c-Kit
18. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response
19. Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways
20. The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation
21. Tyrosine phosphorylation of the erythropoietin receptor: Role for differentiation and mitogenic signal transduction
22. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation
23. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
24. Abnormal erythropoiesis in adult STAT5A-/-5B-/-mice
25. An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice
26. Intron 1 elements promote erythroid-specific GATA-1 gene expression
27. Isolation and characterization of the erythroid progenitor cell: CFU-E
28. An optimized system for studies of EPO-dependent murine pro-erythroblast development
29. Erythropoietin receptor and STAT5-specific pathways promote SKT6 cell hemoglobinization
30. Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor
31. Growth and differentiation of human stem cell factor/erythropoietin-dependent erythroid progenitor cells in vitro
32. GATA-1 dominantly activates a program of erythroid gene expression in factor-dependent myeloid FDCW2 cells
33. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response
34. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation
35. Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5
36. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation
37. Mechanisms of stem cell factor and erythropoietin proliferative co-signaling in FDC2-ER cells
38. Hybrid tyrosine kinase/cytokine receptors transmit mitogenic signals in response to ligand
39. The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage
40. Role of cytokine signaling molecules in erythroid differentiation of mouse fetal liver hematopoietic cells: Functional analysis of signaling molecules by retrovirus-mediated expression
41. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation
42. Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis
43. Co-transduction of cDNAs for c-Kit and steel factor into single CD34+ cord blood cells further enhances the growth of erythroid and multipotential progenitors
44. Interaction of the erythropoietin and stem-cell-factor receptors
45. The distal region and receptor tyrosines of the EPO receptor are non-essential for in vivo erythropoiesis
46. Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2: An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation
47. Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity
48. Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis
49. Bcl-2 targeted overexpression into the erythroid lineage of transgenic mice delays but does not prevent the apoptosis of erythropoietin-deprived erythroid progenitors
50. Stem cell factor and hematopoiesis
51. Effects of continuous stem cell factor administration on normal and erythropoietin-stimulated murine hemopoiesis: Experimental results and model analysis