Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor

Blood

Volumn 100, Issue 4, 2002, Pages 1287-1293

  Kapur, Reuben ^a,b   Chandra, Saurabh ^a,b   Cooper, Ryan ^a,b   McCarthy, Jennifer ^a,b   Williams, David A ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; STEM CELL FACTOR; SYNAPTOPHYSIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ERYTHROID CELL; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENETIC CODE; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0037103356     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v100.4.1287.h81602001287_1287_1293     Document Type: Article

References (31)

1. Hereditary anemias of the mouse: A review for geneticists
2. The Kit ligand encoded at the murine Steel locus: A pleiotropic growth and differentiation factor
3. d mutant
4. Steel-Dickie mutation encodes a c-Kit ligand lacking transmembrane and cytoplasmic domains
5. Differential expression and processing of two cell associated forms of the Kit-ligand: KL-1 and KL-2
6. Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the Steel gene products, stem cell factor
7. Identification and mutation of primary and secondary cleavage sites in murine stem factor cDNA yields biologically active, cell-associated protein
8. Signaling through the interaction of membrane-restricted stem cell factor and c-Kit receptor tyrosine kinase: Genetic evidence for a differential role in erythropoiesis
9. 17H mice
10. 17H mice result from a splicing defect in the steel factor cytoplasmic tail
11. Consequences of exclusive expression in vivo of Kit-ligand lacking the major proteolytic cleavage site
12. 17H mutation affects dimerization and stability phenotypes in hematopoiesis
13. Erythropoietin induces p21 ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells
14. Signal transduction by the high-affinity GMCSF receptor: Two distinct cytoplasmic regions of the common beta subunit responsible for different signal
15. Activation of mitogen-activated protein kinase cascade through erythropoietin receptor
16. Thrombopoietin induces activation of at least two distinct signaling pathways
17. Activation of p38 MAP kinase pathway by erythropoietin and interleukin-3
18. Activation of the stress-activated protein kinases by multiple hematopoietic growth factors with the exception of interleukin-4
19. Hematopoietic growth factors with the exception of IL-4 activate the p38 mitogen activated protein kinase pathway
20. GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xl expression
21. A novel mechanism of cooperation between c-Kit and erythropoietin receptor
22. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding
23. Stem cell factor and hematopoiesis
24. Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-Kit gene encoded protein than its soluble form
25. Role of the stem cell factor (SCF) receptor and the alternative forms of its ligand (SCF) in the induction of long-term growth by stroma cells
26. Responses of the murine myeloid cell line FDC-P1 to soluble and membrane-bound forms of steel factor (SLF)
27. The role of soluble growth factors in inducing transient growth and clonal extinction of stroma cell dependent erythroblastic leukemia cells
28. The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cell in long-term cultures of normal and aplastic anemia bone marrow
29. Signal transduction by receptors with tyrosine kinase activity
30. 2+ influx dependence for ligand-stimulated internalization of the c-Kit receptor
31. Differential stimulation of c-Kit mutants by membrane-bound and soluble steel factor correlates with leukemic potential