Not all tetramer binding CD8+ T cells can produce cytokines and chemokines involved in the effector functions of virus-specific CD8+ T lymphocytes in HIV-1 infected children

Journal of Clinical Immunology

Volumn 25, Issue 1, 2005, Pages 57-67

  Scott Algara, Daniel ^a   Buseyne, Florence ^a   Porrot, Françoise ^a   Corre, Beatrice ^a   Bellal, Nassima ^a,c   Rouzioux, Christine ^b   Blanche, Stephane ^c   Riviere, Yves ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Chemokines; Cytokines; Pediatric AIDS; T lymphocytes; Tetramer

Indexed keywords

CHEMOKINE; CYTOKINE; EPITOPE; GAMMA INTERFERON; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES; TETRAMER; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ARTICLE; CELL SURFACE; CHILD; CORRELATION ANALYSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE FUNCTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; STAINING; STIMULATION; T LYMPHOCYTE; VIRUS; VIRUS LOAD;

ADOLESCENT; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINES, CC; CHILD; CHILD, PRESCHOOL; CYTOKINES; EPITOPES; GENE PRODUCTS, GAG; GENE PRODUCTS, POL; HIV INFECTIONS; HIV-1; HLA-A ANTIGENS; HUMANS; INTERFERON TYPE II; MACROPHAGE INFLAMMATORY PROTEIN-1; OLIGOPEPTIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 15244357617     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10875-005-0358-3     Document Type: Article

References (53)

1. Chouquet C, Autran B, Gomard E, Bouley JM, Calvez V, Katlama C, et al.: Correlation between breadth of memory HIV-specific cytotoxic T cells, viral load and disease progression in HIV infection. AIDS 16:2399-2407, 2002
2. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 68:6103-6110, 1994
3. Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, et al.: Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 68:4650-4655, 1994
4. Ogg GS, Kostense S, Klein MR, Jurriaans S, Hamann D, McMichael AJ, et al.: Longitudinal phenotypic analysis of human immunodeficiency virus type 1- specific cytotoxic T lymphocytes: Correlation with disease progression. J Virol 73:9153-9160, 1999
5. McMichael AJ, Rowland-Jones SL: Cellular immune responses to HIV. Nature 410:980-987, 2001
6. Buseyne F, Burgard M, Teglas JP, Bui E, Rouzioux C, Mayaux MJ, et al.: Early HIV-specific cytotoxic T lymphocytes and disease progression in children born to HIV-infected mothers. AIDS Res Hum Retroviruses 14:1435-1444, 1998
7. Buseyne F, Le Chenadec J, Corre B, Porrot F, Burgard M, Rouzioux C, et al.: Inverse correlation between memory gag-specific cytotoxic T lymphocytes and viral replication in human immunodeficiency virus-infected children. J Infect Dis 186:1589-1596, 2002
8. Carmichael A, Jin X, Sissons P, Borysiewicz L: Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: Differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J Exp Med 177:249-256, 1993
9. Greenough TC, Brettler DB, Somasundaran M, Panicali DL, Sullivan JL: Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes (CTL), virus load, and CD4 T cell loss: Evidence supporting a protective role for CTL in vivo. J Infect Dis 176:118-125, 1997
10. Klein MR, van Baalen CA, Holwerda AM, Kerkhof Garde SR, Bende RJ, Keet IP, et al.: Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: A longitudinal analysis of rapid progressors and long-term asymptomatics. J Exp Med 181:1365-1372, 1995
11. + T lymphocytes responsive to human immunodeficiency virus (HIV) peptide antigens in HIV-infected patients and seronegative persons at high risk for recent HIV exposure. J Infect Dis 178:260-265, 1998
12. Larsson M, Jin X, Ramratnam B, Ogg GS, Engelmayer J, Demoitie MA, et al.: A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals. AIDS 13:767-777, 1999
13. Rininsland FH, Helms T, Asaad RJ, Boehm BO, Tary-Lehmann: Granzyme B ELISPOT assay for ex vivo measurements of T cell immunity. J Immunol Methods 240:143-155, 2000
14. Wilson JD, Ogg GS, Allen RL, Davis C, Shaunak S, Downie J, et al.: Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection. Aids 14:225-233, 2000
15. Scott-Algara D, Buseyne F, Blanche S, Rouzioux C, Jouanne C, Romagne F, et al.: Frequency and phenotyping of human immunodeficiency virus (HIV)-specific CD8+ T cells in HIV-infected children, using major histocompatibility complex class I peptide tetramers. J Infect Dis 183:1565-1573, 2001
16. Buseyne F, Scott-Algara D, Porrot F, Corre B, Bellal N, Burgard M, et al.: Frequencies of ex vivo-activated human immunodeficiency virus type 1-specific gamma-interferon-producing CD8(+) T cells in infected children correlate positively with plasma viral load. J Virol 76:12414-12422, 2002
17. Buseyne F, Blanche S, Schmitt D, Griscelli C, Riviere Y: Detection of HIV-specific cell-mediated cytotoxicity in the peripheral blood from infected children. J Immunol 150:3569-3581, 1993
18. Scott ZA, Chadwick EG, Gibson LL, Catalina MD, McManus MM, Yogev R, et al.: Infrequent detection of HIV-1-specific, but not cytomegalovirus-specific, CD8(+) T cell responses in young HIV-1-infected infants. J Immunol 167:7134-7140, 2001
19. Spiegel HM, Chandwani R, Sheehy ME, Dobroszycki J, Fennelly G, Wiznia A, et al.: The impact of early initiation of highly active antiretroviral therapy on the human immunodeficiency virus type 1-specific CD8 T cell response in children. J Infect Dis 182:88-95, 2000
20. Appay V, Nixon DF, Donahoe SM, Gillespie GM, Dong T, King A, et al.: HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J Exp Med 192:63-75, 2000
21. Goepfert PA, Bansal A, Edwards BH, Ritter GD Jr, Tellez I, McPherson SA, et al.: A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma Interferon. J Virol 74:10249-10255, 2000
22. + T cells in HIV-infected progressors and long-term nonprogressors. J Immunol 165:1082-1092, 2000
23. Goulder PJ, Tang Y, Brander C, Betts MR, Altfeld M, Annamalai K, et al.: Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children. J Exp Med 192:1819-1832, 2000
24. Hel Z, Nacsa J, Kelsall B, Tsai WP, Letvin N, Parks RW, et al.: Impairment of Gag-specific CD8(+) T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaques. J Virol 75:11483-11495, 2001
25. Kern F, Khatamzas E, Surel I, Frommel C, Reinke P, Waldrop SL, et al.: Distribution of human CMV-specific memory T cells among the CD8pos subsets defined by CD57, CD27, and CD45 isoforms. Eur J Immunol 29:2908-2915, 1999
26. Shankar P, Russo M, Harnisch B, Patterson M, Skolnik P, Lieberman J: Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection. Blood 96:3094-3101, 2000
27. Kostense S, Ogg GS, Manting EH, Gillespie G, Joling J, Vandenberghe K, et al.: High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: Evidence for impaired CTL effector function. Eur J Immunol 31:677-686, 2001
28. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A: Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401:708-712, 1999
29. Lieberman J, Shankar P, Manjunath N, Andersson J: Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection. Blood 98:1667-1677, 2001
30. Zanovello P, Vallerani E, Biasi G, Landolfo S, Collavo D: Monoclonal antibody against IFN-gamma inhibits moloney murine sarcoma virus-specific cytotoxic T lymphocyte differentiation. J Immunol 140:1341-1344, 1998
31. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, et al.: CC CKR5: A RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955-1958, 1996
32. + T cells. Science 270:1811-1815, 1995
33. Feng Y, Broder CC, Kennedy PE, Berger EA: HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872-877, 1996
34. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, et al.: Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661-666, 1996
35. Hadida F, Vieillard V, Autran B, Clark-Lewis I, Baggiolini M, Debre P: HIV-specific T cell cytotoxicity mediated by RANTES via the chemokine receptor CCR3. J Exp Med 188:609-614, 1998
36. Wasik TJ, Wierzbicki A, Whiteman VE, Trinchieri G, Lischner HW, Kozbor D: Association between HIV-specific T helper responses and CTL activities in pediatric AIDS. Eur J Immunol 30:117-127, 2000
37. CDC 1994: Revised classification system for human immunodeficiency virus infection in children less than 13 years of age. MMWR Recomm Rep 43:1-10, 1994
38. Mulder J, Resnick R, Saget B, Scheibel S, Herman S, Payne H, et al.: A rapid and simple method for extracting human immunodeficiency virus type 1 RNA from plasma: Enhanced sensitivity. J Clin Microbiol 35:1278-1280, 1997
39. Krausa P, Brywka M III, Savage D, Hui KM, Bunce M, Ngai JL, et al.: Genetic polymorphism within HLA-A*02: significant allelic variation revealed in different populations. Tissue Antigens 45:223-231, 1995
40. Kostense S, Vandenberghe K, Joling J, Van Baarle D, Nanlohy N, Manting E, et al.: Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-gamma+ HIV-specific T cells during progression to AIDS. Blood 99:2505-2511, 2002
41. + T cells in chronic hepatitis C virus infection. J Immunol 169:3447-3458, 2002
42. + T lymphocytes. J Immunol 167:181-187, 2001
43. Gillespie GM, Wills MR, Appay V, O'Callaghan C, Murphy M, Smith N, et al.: Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors. J Virol 74:8140-8150, 2000
44. Kalams SA, Buchbinder SP, Rosenberg ES, Billingsley JM, Colbert DS, Jones NG, et al.: Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection. J Virol 73:6715-6720, 1999
45. + T cell compartment. J Immunol 170:4403-4410, 2003
46. Jennes W, Sawadogo S, Koblavi-Deme S, Vuylsteke B, Maurice C, Roels TH, et al.: Positive association between beta-chemokine-producing T cells and HIV type 1 viral load in HIV-infected subjects in Abidjan, Cote d'Ivoire. AIDS Res Hum Retroviruses 18:171-177, 2002
47. + cells are the predominant T cells in normal humans that synthesize the beta-chemokine macrophage inflammatory protein-1 beta. Proc Natl Acad Sci USA 98:9283-9288, 2001
48. Wagner L, Yang OO, Garcia-Zepeda EA, Ge Y, Kalams SA, Walker BD, et al.: Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans. Nature 391:908-911, 1998
49. Emilie D, Maillot MC, Nicolas JF, Fior R, Galanaud P: Antagonistic effect of interferon-gamma on tat-induced transactivation of HIV long terminal repeat. J Biol Chem 267:20565-20570, 1992
50. Kornbluth RS, Oh PS, Munis JR, Cleveland PH, Richman DD: Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro. J Exp Med 169:1137-1151, 1989
51. + T-lymphocyte populations are related to plasma virus load. J Clin Immunol 22:363-374, 2002
52. Betts MR, Ambrozak DR, Douek DC, Bonhoeffer S, Brenchley JM, Casazza JP, et al.: Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: Relationship to viral load in untreated HIV infection. J Virol 75:11983-11991, 2001
53. Addo MM, Yu XG, Rathod A, Cohen D, Eldridge RL, Strick D, et al.: Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J Virol 77:2081-2092, 2003