Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children

Journal of Experimental Medicine

Volumn 192, Issue 12, 2000, Pages 1819-1831

  Goulder, Philip J R ^a,b   Tang, Yanhua ^a   Brander, Christian ^a   Betts, Michael R ^c   Altfeld, Marcus ^a   Annamalai, Ken ^d   Trocha, Alicja ^a   He, Suqin ^a   Rosenberg, Eric S ^a   Ogg, Graham ^e   O'Callaghan, Christopher A ^e   Kalams, Spyros A ^a   McKinney Jr , Ross E ^f   Mayer, Kenneth ^g   Koup, Richard A ^c   Pelton, Stephen I ^h   Burchett, Sandra K ^b   McIntosh, Kenneth ^b   Walker, Bruce D ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

^e JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^f DUKE UNIVERSITY MEDICAL CENTER   (United States)

^g FENWAY INSTITUTE   (United States)

^h BOSTON MEDICAL CENTER   (United States)

Author keywords

CD8+ T cells; Enzyme linked immunospot; Intracellular cytokine staining; Limiting dilution assays; Peptide major histocompatibility complex tetrameric complexes

Indexed keywords

CD8 ANTIGEN;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; CHILD; CHRONIC DISEASE; CYTOKINE RELEASE; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS LOAD;

ADULT; CD4 LYMPHOCYTE COUNT; CHILD; CHRONIC DISEASE; CYTOTOXICITY TESTS, IMMUNOLOGIC; CYTOTOXICITY, IMMUNOLOGIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; HUMANS; INTERFERON TYPE II; LYMPHOCYTE COUNT; PEPTIDE FRAGMENTS; RNA, VIRAL; T-LYMPHOCYTES, CYTOTOXIC; VIRAL LOAD;

EID: 0034684666     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.12.1819     Document Type: Article

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