Longitudinal phenotypic analysis of human immunodeficiency virus type 1- specific cytotoxic T lymphocytes: Correlation with disease progression

Journal of Virology

Volumn 73, Issue 11, 1999, Pages 9153-9160

  Ogg, Graham S ^a,d   Kostense, Stefan ^b   Klein, Michel R ^b,c   Jurriaans, Suzanne ^b   Hamann, Dörte ^b   McMichael, Andrew J ^a   Miedema, Frank ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL ARTICLE; CORRELATION FUNCTION; CYTOTOXIC T LYMPHOCYTE; DISEASE COURSE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PHENOTYPE; PRIORITY JOURNAL; VIRUS CELL INTERACTION;

EID: 0032846215     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.11.9153-9160.1999     Document Type: Article

References (41)

1. Akbar, A., L. Terry, A. Timms, P. Beverly, and G. Janossy. 1988. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J. Immunol. 140:2171-2178.
2. Akiba, H., H. Nakano, S. Nishinaka, M. Shindo, T. Kobata, M. Atsuta, C. Morimoto, C. F. Ware, N. L. Malinin, D. Wallach, H. Yagita, and K. Okumura. 1998. CD27, a member of the tumor necrosis factor receptor super-family, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. J. Biol. Chem. 273:13353-13358.
3. Altman, J., P. A. H. Moss, P. Goulder, D. Barouch, M. McHeyzer-Williams, J. I. Bell, A. J. McMichael, and M. M. Davis. 1996. Direct visualization and phenotypic analysis of virus-specific T lymphocytes in HIV-infected individuals. Science 274:94-96.
4. Bariou, C., N. Genetet, A. Ruffault, C. Michelet, F. Cartier, and B. Genetet. 1997. Longitudinal study of HIV-specific cytotoxic lymphocytes in HIV type 1-infected patients: relative balance between host immune response and the spread of HIV type 1 infection. AIDS Res, Hum. Retroviruses 13:1301-1312.
5. Cao, Y., L. Qin, L. Zhang, J. Safrit, and D. D. Ho. 1995. Virological and immunological characterisation of long-term survivors of HIV-1 infection. N. Engl. J. Med. 332:201-208.
6. Carmichael, A., X. Jin, P. Sissons, and L. Borysiewicz. 1993. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J. Exp. Med. 177:249-256.
7. Charbonneau, H., N. K. Tonks, K. A. Walsh, and E. H. Fischer. 1988. The leukocyte common antigen CD45: a putative receptor-linked protein tyrosine phosphatase. Proc. Natl. Acad. Sci. USA 85:7182-7189.
8. de Wolf, F., I. Spijkerman, P. T. Schellekens, M. Langendem, C. Kuiken, M. Bakker, M. Roos, R. Coutinho, F. Miedema, and J. Goudsmit. 1997. AIDS prognosis based on HIV-1 RNA, CD4+ T-cell count and function: markers with reciprocal predictive value over time after seroconversion. AIDS 11: 1799-1806.
9. Dorrell, L., T. Dong, G. S. Ogg, S. McAdam, O. Anzala, T. Rostron, C. Conlon, A. J. McMichael, and S. Rowland-Jones. 1999. Distinct recognition of A clade human immunodeficiency virus type 1 epitopes by cytotoxic T lymphocytes generated from donors infected in Africa. J. Virol. 73:1708-1714.
10. Dunbar, P. R., J. L. Chen, D. Chao, N. Rust, H. Teisserenc, G. S. Ogg, P. Romero, P. Weynants, and V. Cerundolo. 1999 Cutting edge: rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma. J. Immunol. 162:6959-6962.
11. Dunbar, P. R., G. S. Ogg, J. Chen, N. Rust. P. van der Bruggen, and V. Cerundolo. 1998. Direct isolation, phenotyping and cloning of low frequency antigen-specific CTL from peripheral blood. Curr. Biol. 8:413-416.
12. Dyer, W. B., G. S. Ogg, M.-A. Demoite, X. Jin, A. F. Geczy, S. L. Rowland-Jones, A. J. McMichael, D. F. Nixon, and J. S. Sullivan. 1999. Strong human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte activity in Sydney Blood Bank Cohort patients infected with nef-defective HIV type 1 J. Virol. 73:436-443.
13. Geretti, A. M., M. E. Dings, C. A. van Els, C. A. van Baalen, F. J. Wijholds, J. C. Borleffs, and A. D. Osterhaus. 1996. Human immunodeficiency virus type 1 (HIV-1)- and Epstein-Barr virus-specific cytotoxic T lymphocyte precursors exhibit different kinetics in HIV-1-infected persons. J. Infect. Dis. 174:34-45.
14. Gotch, F. M., D. F. Nixon, N. Alp, A. J. McMichael, and L. K. Borysiewicz. 1990. High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals. Int. Immunol. 2:707.
15. Goulder, P. J. R., A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. 1997. Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation. J. Exp. Med. 185:1423-1433.
16. Greenough, T. C., D. B. Brettler, M. Somasundaran, D. L. Panicali, and J. L. Sullivan. 1997. HIV-specific CTL, virus load and CD4+ T cell loss: evidence supporting a protective role for CTL in vivo. J. Infect. Dis. 176:118-125.
17. Hamann, D., P. A. Baars, M. H. Rep, B. Hooibrink, S. R. Kerkhof-Garde, M. R. Klein, and R. A. W. van Lier. 1997. Phenotypic and functional separation of memory and effector human CD8+ T cells. J. Exp. Med. 186:1407-1418.
18. Hamann, D., M. T. L. Roos, and R. A. W. van Lier. 1999. Faces and phases of human CD8 T-cell development. Immunol. Today 20:177-180.
19. Harrer, T., E. Harrer, S. A. Kalams, T. Elbeik, S. I. Staprans, M. B. Feinberg, Y. Cao, D. D. Ho, T. Yilma, A. M. Caliendo, R. P. Johnson, S. P. Buchbinder, and B. D. Walker. 1996. Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection. AIDS Res. Hum. Retroviruses 12:585-592.
20. Kalams, S. A., R. P. Johnson, A. K. Trocha, M. J. Dynan, S. Ngo, R. T. D'Aquila, J. T. Kurnick, and B. D. Walker. 1994. Longitudinal analysis of TCR gene usage by HIV-1 envelope-specific CTL clones reveals a limited TCR repertoire. J. Exp. Med. 179:1261-1271.
21. Kersten, M. J., M. R. Klein, A. M. Holwerda, F. Miedema, and M. H. van Oers. 1997. Epstein-Barr virus-specific cytotoxic T cell responses in HIV-1 infection: different kinetics in patients progressing to opportunistic infection or non-Hodgkin's lymphoma. J. Clin. Investig. 99:1525-1533.
22. Klein, M. R., C. A. Van Baalen, A. M. Holwerda, S. R. K. Garde, R. J. Bende, I. P. M. Keet, J. K. M. Eeftinck Schattenkerk, A. D. M. E. Osterhaus, H. Schuitemaker, and F. Miedema. 1995. Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics. J. Exp. Med. 181:1365-1372.
23. McLean, A. R., and C. A. Michie. 1995. In vivo estimates of division and death rates of human T lymphocytes. Proc. Natl. Acad. Sci. USA 92:3707-3711.
24. Moss, P. A. H., S. L Rowland-Jones, P. M. Frodsham, S. McAdam, P. Giangrande, A. J. McMichael, and J. I. Bell. 1995. Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors. Proc. Natl. Acad. Sci. USA 92:5773-5777.
25. Murali-Krishna, K., J. D. Altman, M. Suresh, D. J. D. Sourdive, A. J. Zajac, J. D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a re-evaluation of bystander activation during viral infection. Immunity 8:177-187.
26. Musey, L., J. Hughes, T. Schaker, T. Shea, L. Corey, and M. J. McElrath. 1997. CTL responses, viral load and disease progression in early HIV infection. N. Engl. J. Med. 337:1267-1274.
27. Mustelin, T., K. M. Coggeshall, and A. Altman. 1989. Rapid activation of the T cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase. Proc. Natl. Acad. Sci. USA 86:6302-6306.
28. Ogg, G., X. Jin, S. Bonhoeffer, P. Dunbar, M. Nowak, S. Monard, J. Segal, Y. Cao, S. Rowland-Jones, V. Cerundolo, A. Hurley, M. Markowitz, D. Ho, D. Nixon, and A. McMichael. 1998. Quantitation of HIV-specific CTL and plasma load of viral RNA. Science 279:2103-2106.
29. Ogg, G. S., X. Jin, S. Bonhoeffer, P. Moss, M. A. Nowak, S. Monard, J. P. Segal, Y. Cao, S. L. Rowland-Jones, A. Hurley, M. Markowitz, D. D. Ho, A. J. McMichael, and D. F. Nixon. 1999. Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy. J. Virol. 73:797-800.
30. Pantaleo, G., A. De Maria, S. Koenig, L. Butini, B. Moss, M. Baseler, H. C. Lane, and A. S. Fauci. 1990. CD8+ T lymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immunodeficiency virus-specific cytotoxicity. Proc. Natl. Acad. Sci. USA 87:4818-4822.
31. Pantaleo, G., H. Soudeyns, J. F. Demarest, M. Vaccarezza, S. Paolucci, M. Daucher, O. J. Cohen, F. Denis, W. E. Biddis, R. P. Sekaly, and A. S. Fauci. 1997. Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. Proc. Natl. Acad. Sci. USA 94:9848-9853.
32. Parker, K. C., M. A. Bednarek, L. K. Hull, U. Utz, B. Cunningham, H. J. Zweerink, W. E. Biddison, and J. E. Coligan. 1992. Sequence motifs important for peptide binding to the human MHC class I molecule, HLA-A2. J. Immunol. 149:3580-3587.
33. Pontesilli, O., M. R. Klein, S. R. Kerkhof-Garde, N. G. Pakker, F. de Wolf, H. Schuilemaker, and F. Miedema. 1998. Longitudinal analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte responses: a predominant gag-specific response is associated with nonprogressive infection. J. Infect. Dis. 178:1008-1018.
34. Rinaldo, C., X.-L. Huang, Z. Fan, M. Ding, L. Beltz, A. Logar, D. Panicali, G. Mazzara, J. Liebmann, M. Cottrill, and P. Gupta. 1995. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. J. Virol. 69:5838-5842.
35. Riviere, Y., M. B. McChesney, F. Porrot, S. F. Tanneau, P. Sansonetti, O. Lopez, G. Pialoux, V. Feuillie, M. Mollereau, S. Chamaret, et al. 1995. Gag-specific cytotoxic responses to HIV type 1 are associated with a decreased risk of progression to AIDS-related complex or AIDS. AIDS Res. Hum. Retroviruses 11:903-907.
36. Steven, N. M., N. E. Annels, A. Kumar, A. M. Leese, M. G. Kurilla, and A. B. Rickinson. 1997. Immediate early and early lytic cycle proteins are frequent targets of the Epstein-Barr virus-induced cytotoxic T cell response. J. Exp. Med. 185:1605-1617.
37. Tan, L. C., N. Gudgeon, N. E. Annels, P. Hansasuta, C. A. O'Callaghan, S. Rowland-Jones, A. J. McMichael, A. B. Rickinson, and M. F. Callan. 1999. A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers. J. Immunol. 162:1827-1835.
38. Tan, R., X. Xu, G. S. Ogg, P. Hansasuta, T. Dong, T. Rostron, G. Luzzi, C. P. Conlon, G. R. Screaton, A. J. McMichael, and S. Rowland-Jones. 1999. Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome. Blood 93:1506-1510.
39. Tsomides, T. J., A. Aldovlni, R. P. Johnson, B. D. Walker, R. A. Young, and H. N. Eisen. 1994. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. J. Exp. Med. 180:1283-1293.
40. Wilson, J. D. K., G. S. Ogg, R. L. Allen, P. J. Goulder, T. Kelleher, A. Sewell, C. A. E. O'Callaghan, M. F. C. Callan, S. L. Rowland-Jones, and A. J. McMichael. 1998. Oligoclonal expansions of CD8+ T cells in chronic HIV infection are antigen-specific. J. Exp. Med. 188:785-790.
41. Zajac, A. J., J. N. Blattman, K. Murali-Krishna, D. J. Sourdive, M. Suresh, J. D. Altman, and R. Ahmed. 1998. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188:2205-2213.