메뉴 건너뛰기




Volumn 30, Issue 3, 2004, Pages 327-340

Humanin: After the discovery

Author keywords

Alzheimer's disease; Amyloid ; A PP; Cell death; Humanin; Neuroprotection

Indexed keywords

HUMANIN; STRESS ACTIVATED PROTEIN KINASE; NEUROPROTECTIVE AGENT; PROTEIN; SIGNAL PEPTIDE;

EID: 15244353904     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1385/MN:30:3:327     Document Type: Review
Times cited : (43)

References (42)
  • 1
    • 0034602331 scopus 로고    scopus 로고
    • Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein
    • Hashimoto Y., Niikura T., Ito Y., and Nishimoto I. (2000) Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein. J. Biol. Chem. 275, 34,541-34,551.
    • (2000) J. Biol. Chem. , vol.275
    • Hashimoto, Y.1    Niikura, T.2    Ito, Y.3    Nishimoto, I.4
  • 2
    • 0036488129 scopus 로고    scopus 로고
    • Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: Involvement of NO synthase via a novel pertussis toxin target
    • Hashimoto Y., Ito Y., Arakawa E., et al. (2002) Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target. J. Neurochem. 80, 426-437.
    • (2002) J. Neurochem. , vol.80 , pp. 426-437
    • Hashimoto, Y.1    Ito, Y.2    Arakawa, E.3
  • 4
    • 0037010299 scopus 로고    scopus 로고
    • Death and survival of neuronal cells exposed to Alzheimer's insults
    • Niikura T., Hashimoto Y., Tajima H., and Nishimoto I. (2002) Death and survival of neuronal cells exposed to Alzheimer's insults. J. Neurosci. Res. 70, 380-391.
    • (2002) J. Neurosci. Res. , vol.70 , pp. 380-391
    • Niikura, T.1    Hashimoto, Y.2    Tajima, H.3    Nishimoto, I.4
  • 5
    • 0029671219 scopus 로고    scopus 로고
    • Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3
    • Vito P., Lacana E., and D'Adamio L. (1996) Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 271, 521-525.
    • (1996) Science , vol.271 , pp. 521-525
    • Vito, P.1    Lacana, E.2    D'Adamio, L.3
  • 6
    • 4243333514 scopus 로고    scopus 로고
    • A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ
    • Correction in: Proc. Natl. Acad. Sci. USA 98, 12,854
    • Hashimoto Y., Niikura T., Tajima H., et al. (2001) A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. Proc. Natl. Acad. Sci. USA 98, 6336-6341. Correction in: Proc. Natl. Acad. Sci. USA 98, 12,854.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6336-6341
    • Hashimoto, Y.1    Niikura, T.2    Tajima, H.3
  • 7
    • 0013056674 scopus 로고    scopus 로고
    • Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer's disease relevant insults
    • Yamagishi Y., Hashimoto Y., Niikura T., and Nishimoto I. (2003) Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer's disease relevant insults. Peptides 24, 585-595.
    • (2003) Peptides , vol.24 , pp. 585-595
    • Yamagishi, Y.1    Hashimoto, Y.2    Niikura, T.3    Nishimoto, I.4
  • 8
    • 0021856417 scopus 로고
    • Signal sequences. The limits of variation
    • von Heijne G. (1985) Signal sequences. The limits of variation. J. Mol. Biol. 184, 99-105.
    • (1985) J. Mol. Biol. , vol.184 , pp. 99-105
    • Von Heijne, G.1
  • 9
    • 0035576106 scopus 로고    scopus 로고
    • Detailed characterization of neuroprotection by a rescue factor Humanin against various Alzheimer's disease-relevant insults
    • Hashimoto Y., Niikura T., Ito Y., et al. (2001) Detailed characterization of neuroprotection by a rescue factor Humanin against various Alzheimer's disease-relevant insults. J. Neurosci. 21, 9235-9245.
    • (2001) J. Neurosci. , vol.21 , pp. 9235-9245
    • Hashimoto, Y.1    Niikura, T.2    Ito, Y.3
  • 10
    • 0036673025 scopus 로고    scopus 로고
    • A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity
    • Caricasole A., Bruno V., Cappuccio I., Melchiorri D., Copani A., and Nicoletti F. (2002) A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity. FASEB J. 16, 1331-1333.
    • (2002) FASEB J. , vol.16 , pp. 1331-1333
    • Caricasole, A.1    Bruno, V.2    Cappuccio, I.3    Melchiorri, D.4    Copani, A.5    Nicoletti, F.6
  • 11
    • 12444261796 scopus 로고    scopus 로고
    • Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: Functional potentiation by isomerization and dimerization
    • Terashita K., Hashimoto Y., Niikura T., et al. (2003) Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization. J. Neurochem. 85, 1521-1538.
    • (2003) J. Neurochem. , vol.85 , pp. 1521-1538
    • Terashita, K.1    Hashimoto, Y.2    Niikura, T.3
  • 12
    • 0033539510 scopus 로고    scopus 로고
    • Serine racemase: A glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission
    • Wolosker H., Blackshaw S., and Snyder S. H. (1999) Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc. Natl. Acad. Sci. USA 96, 13,409-13,414.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96
    • Wolosker, H.1    Blackshaw, S.2    Snyder, S.H.3
  • 13
    • 0034805623 scopus 로고    scopus 로고
    • Mechanisms of neuroprotection by a novel rescue factor Humanin from Swedish mutant amyloid precursor protein
    • Hashimoto Y., Ito Y., Niikura T., et al. (2001) Mechanisms of neuroprotection by a novel rescue factor Humanin from Swedish mutant amyloid precursor protein. Biochem. Biophys. Res. Commun. 283, 460-468.
    • (2001) Biochem. Biophys. Res. Commun. , vol.283 , pp. 460-468
    • Hashimoto, Y.1    Ito, Y.2    Niikura, T.3
  • 14
    • 0036769574 scopus 로고    scopus 로고
    • Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein relevant insults
    • Kawasumi M., Hashimoto Y., Chiba T., et al. (2002) Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein relevant insults. NeuroSignals 11, 236-250.
    • (2002) NeuroSignals , vol.11 , pp. 236-250
    • Kawasumi, M.1    Hashimoto, Y.2    Chiba, T.3
  • 15
    • 0030723983 scopus 로고    scopus 로고
    • Binding of β-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease
    • Yaar M., Zhai S., Pilch P. F., et al. (1997) Binding of β-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J. Clin. Invest. 100, 2333-2340.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2333-2340
    • Yaar, M.1    Zhai, S.2    Pilch, P.F.3
  • 16
    • 0032533723 scopus 로고    scopus 로고
    • NGF induces apoptosis in a human neuroblastoma cell line expressing the neurotrophin receptor p75NTR
    • Kuner P. and Hertel C. (1998) NGF induces apoptosis in a human neuroblastoma cell line expressing the neurotrophin receptor p75NTR. J. Neurosci. Res. 54, 465-474.
    • (1998) J. Neurosci. Res. , vol.54 , pp. 465-474
    • Kuner, P.1    Hertel, C.2
  • 17
    • 0042839610 scopus 로고    scopus 로고
    • Characterization of the toxic mechanism triggered by Alzheimer's amyloid-β peptides via p75 neurotrophin receptor in neuronal hybrid cells
    • Tsukamoto E., Hashimoto Y., Kanekura K., Niikura T., Aiso S., and Nishimoto I. (2003) Characterization of the toxic mechanism triggered by Alzheimer's amyloid-β peptides via p75 neurotrophin receptor in neuronal hybrid cells. J. Neurosci. Res. 73, 627-636.
    • (2003) J. Neurosci. Res. , vol.73 , pp. 627-636
    • Tsukamoto, E.1    Hashimoto, Y.2    Kanekura, K.3    Niikura, T.4    Aiso, S.5    Nishimoto, I.6
  • 18
    • 0030902595 scopus 로고    scopus 로고
    • Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity Proc
    • Dore S., Kar S., and Quirion R. (1997) Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity Proc. Natl. Acad. Sci. USA 94, 4772-4777.
    • (1997) Natl. Acad. Sci. USA , vol.94 , pp. 4772-4777
    • Dore, S.1    Kar, S.2    Quirion, R.3
  • 20
    • 0023254674 scopus 로고
    • Cerebral amyloid angiopathy. A critical review
    • Vinters H. V. (1987) Cerebral amyloid angiopathy. A critical review. Stroke 18, 311-324.
    • (1987) Stroke , vol.18 , pp. 311-324
    • Vinters, H.V.1
  • 21
    • 0037262465 scopus 로고    scopus 로고
    • Humanin rescues human cerebrovascular smooth muscle cells from Aβ-induced toxicity
    • Jung S. S. and Van Nostrand W. E. (2003) Humanin rescues human cerebrovascular smooth muscle cells from Aβ-induced toxicity. J. Neurochem. 84, 266-272.
    • (2003) J. Neurochem. , vol.84 , pp. 266-272
    • Jung, S.S.1    Van Nostrand, W.E.2
  • 22
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Erratum in: Nature (1993) 364, 362
    • Rosen D. R., Siddique T., Patterson D., et al. (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362, 59-62. Erratum in: Nature (1993) 364, 362.
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1    Siddique, T.2    Patterson, D.3
  • 24
    • 0035869351 scopus 로고    scopus 로고
    • Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant APP through IGF-I receptor in an IGF-binding protein-sensitive manner
    • Niikura T., Hashimoto Y., Okamoto T., et al. (2001) Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant APP through IGF-I receptor in an IGF-binding protein-sensitive manner. J. Neurosci. 21, 1902-1910.
    • (2001) J. Neurosci. , vol.21 , pp. 1902-1910
    • Niikura, T.1    Hashimoto, Y.2    Okamoto, T.3
  • 25
    • 20244361899 scopus 로고    scopus 로고
    • Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death
    • Hashimoto Y., Tsuji O., Niikura T., et al. (2003) Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death. J. Neurochem. 84, 864-877.
    • (2003) J. Neurochem. , vol.84 , pp. 864-877
    • Hashimoto, Y.1    Tsuji, O.2    Niikura, T.3
  • 26
    • 0037124108 scopus 로고    scopus 로고
    • Signaling events in amyloid β-peptide-induced neuronal death and insulin-like growth factor I protection
    • Wei W., Wang X., and Kusiak J. W. (2002) Signaling events in amyloid β-peptide-induced neuronal death and insulin-like growth factor I protection. J. Biol. Chem. 277, 17,649-17,656.
    • (2002) J. Biol. Chem. , vol.277
    • Wei, W.1    Wang, X.2    Kusiak, J.W.3
  • 27
    • 0034525215 scopus 로고    scopus 로고
    • Antibody regulated neurotoxic function of cell surface β-amyloid precursor protein
    • Sudo H., Jiang H., Yasukawa T., et al. (2000) Antibody regulated neurotoxic function of cell surface β-amyloid precursor protein. Mol. Cell. Neurosci. 16, 708-723.
    • (2000) Mol. Cell. Neurosci. , vol.16 , pp. 708-723
    • Sudo, H.1    Jiang, H.2    Yasukawa, T.3
  • 28
    • 0034029430 scopus 로고    scopus 로고
    • A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis
    • Rohn T. T., Ivins K. J., Bahr B. A., Cotman C. W., and Cribbs D. H. (2000) A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis. J. Neurochem. 74, 2331-2342.
    • (2000) J. Neurochem. , vol.74 , pp. 2331-2342
    • Rohn, T.T.1    Ivins, K.J.2    Bahr, B.A.3    Cotman, C.W.4    Cribbs, D.H.5
  • 29
    • 15844386159 scopus 로고    scopus 로고
    • G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP
    • Yamatsuji T., Matsui T., Okamoto T., et al. (1996) G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP. Science 272, 1349-1352.
    • (1996) Science , vol.272 , pp. 1349-1352
    • Yamatsuji, T.1    Matsui, T.2    Okamoto, T.3
  • 30
    • 0030738912 scopus 로고    scopus 로고
    • G protein βγ complex-mediated apoptosis by familial Alzheimer's disease mutant of APP
    • Giambarella U., Yamatsuji T., Okamoto T., et al. (1997) G protein βγ complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. EMBO J. 16, 4897-4907.
    • (1997) EMBO J. , vol.16 , pp. 4897-4907
    • Giambarella, U.1    Yamatsuji, T.2    Okamoto, T.3
  • 32
    • 0042934160 scopus 로고    scopus 로고
    • The cytoplasmic domain of Alzheimer's amyloid-β protein precursor causes sustained ASK1/JNK-mediated neurotoxic signal via dimerization
    • Hashimoto Y., Niikura T., Chiba T., et al. (2003) The cytoplasmic domain of Alzheimer's amyloid-β protein precursor causes sustained ASK1/JNK-mediated neurotoxic signal via dimerization. J. Pharmacol. Exp. Ther. 306, 889-902.
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 889-902
    • Hashimoto, Y.1    Niikura, T.2    Chiba, T.3
  • 33
    • 0038485614 scopus 로고    scopus 로고
    • Humanin peptide suppresses apoptosis by interfering with Bax activation
    • Guo B., Zhai D., Cabezas E., et al. (2003) Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature 423, 456-461.
    • (2003) Nature , vol.423 , pp. 456-461
    • Guo, B.1    Zhai, D.2    Cabezas, E.3
  • 36
    • 0037166058 scopus 로고    scopus 로고
    • Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults
    • Tajima H., Niikura T., Hashimoto Y., et al. (2002) Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. Neurosci. Lett. 324, 227-231.
    • (2002) Neurosci. Lett. , vol.324 , pp. 227-231
    • Tajima, H.1    Niikura, T.2    Hashimoto, Y.3
  • 37
    • 0037363692 scopus 로고    scopus 로고
    • A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults
    • Niikura T., Hashimoto Y., Tajima H., et al. (2003) A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults. Eur. J. Neurosci. 17, 1150-1158.
    • (2003) Eur. J. Neurosci. , vol.17 , pp. 1150-1158
    • Niikura, T.1    Hashimoto, Y.2    Tajima, H.3
  • 38
    • 0034131044 scopus 로고    scopus 로고
    • Impaired proteasome function in Alzheimer's disease
    • Keller J. N., Hanni K. B., and Markesbery W. R. (2000) Impaired proteasome function in Alzheimer's disease. J. Neurochem. 75, 436-439.
    • (2000) J. Neurochem. , vol.75 , pp. 436-439
    • Keller, J.N.1    Hanni, K.B.2    Markesbery, W.R.3
  • 40
    • 0242268394 scopus 로고    scopus 로고
    • Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell curvival and apoptosis
    • Ikonen M., Liu B., Hashimoto Y., et al. (2003) Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell curvival and apoptosis. Proc. Natl. Acad. Sci. USA 100, 13,042-13,047.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100
    • Ikonen, M.1    Liu, B.2    Hashimoto, Y.3
  • 41
    • 0035678839 scopus 로고    scopus 로고
    • [Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo
    • Mamiya T. and Ukai M. (2001) [Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo. Br. J. Pharmacol., 134, 1597-1599.
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 1597-1599
    • Mamiya, T.1    Ukai, M.2
  • 42
    • 20144387217 scopus 로고    scopus 로고
    • A humanin derivative, S14G-HN, prevents amyloid-β-induced memory impairment in mice
    • in press
    • Tajima H., Kawasumi M., Chiba T., et al. A humanin derivative, S14G-HN, prevents amyloid-β-induced memory impairment in mice. J. Neurosci. Res. in press.
    • J. Neurosci. Res.
    • Tajima, H.1    Kawasumi, M.2    Chiba, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.