Non-thiol farnesyltransferase inhibitors: Utilization of the far aryl binding site by arylthienylacryloyl-aminobenzophenones

Archiv der Pharmazie

Volumn 338, Issue 1, 2005, Pages 9-17

  Mitsch, Andreas ^b   Altenkämper, Mirko ^a   Sattler, Isabel ^c   Schlitzer, Martin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c BIOMATERIALS DEPARTMENT   (Germany)

Author keywords

Aryl binding site; Non thiol farnesyltransferase inhibitors; Structure activity relationships

Indexed keywords

AMINE; BENZOPHENONE DERIVATIVE; FARNESYL TRANS TRANSFERASE; N [3 BENZOYL 4 (4 TOLYLACETYLAMINO)PHENYL] 3 (4 BROMO 2 THIENYL)ACRYLIC ACID AMIDE; N [3 BENZOYL 4 (4 TOLYLACETYLAMINO)PHENYL] 3 (5 BROMO 2 THIENYL)ACRYLIC ACID AMIDE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL BOND; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; ENZYME ACTIVE SITE; IC 50; PRIORITY JOURNAL; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ACRYLAMIDES; ALKYL AND ARYL TRANSFERASES; BENZOPHENONES; BINDING SITES; FARNESYLTRANSTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 14944344437     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200400886     Document Type: Article

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