-
1
-
-
0031983131
-
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis
-
(1998)
Mol Cell Biol
, vol.18
, pp. 85-92
-
-
Barrington, R.E.1
Subler, M.A.2
Rands, E.3
Omer, C.A.4
Miller, P.J.5
Hundley, J.E.6
Koester, S.K.7
Troyer, D.A.8
Bearss, D.J.9
Conner, M.W.10
-
2
-
-
0033614962
-
Essential role for oncogenic Ras in tumour maintenance
-
(1999)
Nature
, vol.400
, pp. 468-472
-
-
Chin, L.1
Tam, A.2
Pomerantz, J.3
Wong, M.4
Holash, J.5
Bardeesy, N.6
Shen, Q.7
O'Hagan, R.8
Pantginis, J.9
Zhou, H.10
-
3
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
4
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
(1999)
Nat Genet
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.L.3
Baldocchi, R.4
Godfrey, T.5
Collins, C.6
Pinkel, D.7
Powell, B.8
Mills, G.B.9
Gray, J.W.10
-
5
-
-
0030911052
-
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
-
(1997)
Cell
, vol.89
, pp. 457-467
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Khwaja, A.3
Marte, B.M.4
Pappin, D.5
Das, P.6
Waterfield, M.D.7
Ridley, A.8
Downward, J.9
-
9
-
-
0033025369
-
Inhibition of the epidermal growth factor receptor family of tyrosine kinases as an approach to cancer chemotherapy: Progression from reversible to irreversible inhibitors
-
(1999)
Pharmacol Ther
, vol.82
, pp. 207-218
-
-
Fry, D.W.1
-
13
-
-
0032191393
-
Tumor surveillance via the ARF-p53 pathway
-
(1998)
Genes Dev
, vol.12
, pp. 2984-2991
-
-
Sherr, C.J.1
-
14
-
-
0033119372
-
BCL-2 gene family and the regulation of programmed cell death
-
(1999)
Cancer Res
, vol.59
, Issue.SUPPL.
-
-
Korsmeyer, S.J.1
-
15
-
-
0034659849
-
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis
-
(2000)
Oncogene
, vol.19
, pp. 2951-2956
-
-
Ise, K.1
Nakamura, K.2
Nakao, K.3
Shimizu, S.4
Harada, H.5
Ichise, T.6
Miyoshi, J.7
Gondo, Y.8
Ishikawa, T.9
Aiba, A.10
-
16
-
-
0034677755
-
Mechanism-based target identification and drug discovery in cancer research
-
(2000)
Science
, vol.287
, pp. 1969-1973
-
-
Gibbs, J.B.1
-
17
-
-
0032529165
-
Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo
-
(1998)
Genes Dev
, vol.12
, pp. 2469-2474
-
-
Robles, A.I.1
Rodriguez-Puebla, M.L.2
Glick, A.B.3
Trempus, C.4
Hansen, L.5
Sicinski, P.6
Tennant, R.W.7
Weinberg, R.A.8
Yuspa, S.H.9
Conti, C.J.10
-
19
-
-
0029111934
-
Cyclin D1 provides a link between development and oncogenesis in the retina and breast
-
(1995)
Cell
, vol.82
, pp. 621-630
-
-
Sicinski, P.1
Donaher, J.L.2
Parker, S.B.3
Li, T.4
Fazeli, A.5
Gardner, H.6
Haslam, S.Z.7
Bronson, R.T.8
Elledge, S.J.9
Weinberg, R.A.10
-
21
-
-
0345135149
-
K-ras is an essential gene in the mouse with partial functional overlap with N-ras
-
(1997)
Genes Dev
, vol.11
, pp. 2468-2481
-
-
Johnson, L.1
Greenbaum, D.2
Cichowski, K.3
Mercer, K.4
Murphy, E.5
Schmitt, E.6
Bronson, R.T.7
Umanoff, H.8
Edelmann, W.9
Kucherlapati, R.10
-
24
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.M.5
Fanning, S.6
Zimmermann, J.7
Lydon, N.B.8
-
25
-
-
0031454003
-
CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
-
(1997)
Blood
, vol.90
, pp. 4947-4952
-
-
Carroll, M.1
Ohno-Jones, S.2
Tamura, S.3
Buchdunger, E.4
Zimmermann, J.5
Lydon, N.B.6
Gilliland, D.G.7
Druker, B.J.8
-
28
-
-
0033598202
-
Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis
-
(1999)
Curr Biol
, vol.9
, pp. 1047-1049
-
-
Frisch, S.M.1
-
32
-
-
12244277954
-
Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent
-
(2000)
Anticancer Drug Des
, vol.15
, pp. 29-41
-
-
Mendel, D.B.1
Laird, A.D.2
Smolich, B.D.3
Blake, R.A.4
Liang, C.5
Hannah, A.L.6
Shaheen, R.M.7
Ellis, L.M.8
Weitman, S.9
Shawver, L.K.10
-
35
-
-
0034635264
-
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
Irie-Sasaki, J.2
Jones, R.G.3
Oliveira-dos-Santos, A.J.4
Stanford, W.L.5
Bolon, B.6
Wakeham, A.7
Itie, A.8
Bouchard, D.9
Kozieradzki, I.10
-
36
-
-
0029975029
-
Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor
-
(1996)
J Med Chem
, vol.39
, pp. 1823-1835
-
-
Rewcastle, G.W.1
Palmer, B.D.2
Thompson, A.M.3
Bridges, A.J.4
Cody, D.R.5
Zhou, H.6
Fry, D.W.7
McMichael, A.8
Denny, W.A.9
-
39
-
-
0033063777
-
Cyclin-dependent kinases: Initial approaches to exploit a novel therapeutic target
-
(1999)
Pharmacol Ther
, vol.82
, pp. 285-292
-
-
Sausville, E.A.1
Zaharevitz, D.2
Gussio, R.3
Meijer, L.4
Louarn-Leost, M.5
Kunick, C.6
Schultz, R.7
Lahusen, T.8
Headlee, D.9
Stinson, S.10
-
41
-
-
0034017744
-
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases
-
(2000)
Mol Pharmacol
, vol.57
, pp. 976-983
-
-
Ishizaki, T.1
Uehata, M.2
Tamechika, I.3
Keel, J.4
Nonomura, K.5
Maekawa, M.6
Narumiya, S.7
-
44
-
-
14444279192
-
Identification of a novel inhibitor of mitogen-activated protein kinase kinase
-
(1998)
J Biol Chem
, vol.273
, pp. 18623-18632
-
-
Favata, M.F.1
Horiuchi, K.Y.2
Manos, E.J.3
Daulerio, A.J.4
Stradley, D.A.5
Feeser, W.S.6
Van Dyk, D.E.7
Pitts, W.J.8
Earl, R.A.9
Hobbs, F.10
-
47
-
-
0034678033
-
Target-oriented and diversity-oriented organic synthesis in drug discovery
-
(2000)
Science
, vol.287
, pp. 1964-1969
-
-
Schreiber, S.L.1
|