-
1
-
-
0037142034
-
Mice deficient in the RAc activator Tiam1 are resistant to Ras-induced skin tumours
-
Malliri, A. et al. Mice deficient in the RAc activator Tiam1 are resistant to Ras-induced skin tumours. Nature 417, 867-871 (2002).
-
(2002)
Nature
, vol.417
, pp. 867-871
-
-
Malliri, A.1
-
2
-
-
0026677375
-
Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein
-
Donaldson, J. G., Finazzi, D. & Klausner, R. D. Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein. Nature 360, 350-352 (1992).
-
(1992)
Nature
, vol.360
, pp. 350-352
-
-
Donaldson, J.G.1
Finazzi, D.2
Klausner, R.D.3
-
3
-
-
0026746713
-
Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF
-
Helms, J. B. & Rothman, J. E. Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF. Nature 360, 352-354 (1992).
-
(1992)
Nature
, vol.360
, pp. 352-354
-
-
Helms, J.B.1
Rothman, J.E.2
-
4
-
-
0002955384
-
Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: Involvement of specific residues of the Sec7 domain
-
Peyroche, A. et al. Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain. Mol. Cell 3, 275-285 (1999).
-
(1999)
Mol. Cell
, vol.3
, pp. 275-285
-
-
Peyroche, A.1
-
5
-
-
0035942221
-
Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers
-
Mayer, G. et al. Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers. Proc. Natl Acad. Sci. USA 98, 4961-4965 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4961-4965
-
-
Mayer, G.1
-
6
-
-
0037125232
-
Identification of the first Rho-GEF inhibitor, TRIPα, which targets the RhoA-specific GEF domain of Trio
-
Schmidt, S., Diriong, S., Mery, J., Fabbrizio, E. & Debant, A. Identification of the first Rho-GEF inhibitor, TRIPα, which targets the RhoA-specific GEF domain of Trio. FEBS Lett. 523, 35-42 (2002).
-
(2002)
FEBS Lett.
, vol.523
, pp. 35-42
-
-
Schmidt, S.1
Diriong, S.2
Mery, J.3
Fabbrizio, E.4
Debant, A.5
-
7
-
-
0028801195
-
The kinetic mechanism of Ran-nucleotide exchange catalyzed by RCC1
-
Klebe, C., Prinz, H., Wittinghofer, A. & Goody, R. S. The kinetic mechanism of Ran-nucleotide exchange catalyzed by RCC1. Biochemistry 34, 12543-12552 (1995).
-
(1995)
Biochemistry
, vol.34
, pp. 12543-12552
-
-
Klebe, C.1
Prinz, H.2
Wittinghofer, A.3
Goody, R.S.4
-
8
-
-
0032546533
-
Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm
-
Lenzen, C., Cool, R. H., Prinz, H., Kuhlmann, J. & Wittinghofer, A. Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm. Biochemistry 37, 7420-7430 (1998).
-
(1998)
Biochemistry
, vol.37
, pp. 7420-7430
-
-
Lenzen, C.1
Cool, R.H.2
Prinz, H.3
Kuhlmann, J.4
Wittinghofer, A.5
-
9
-
-
0036656168
-
Exchange factors, effectors, GAPs and motor proteins: Common thermodynamic and kinetic principles for different functions
-
Goody, R. S. & Hofmann-Goody, W. Exchange factors, effectors, GAPs and motor proteins: common thermodynamic and kinetic principles for different functions. Eur. Biophys. J. 31, 268-274 (2002).
-
(2002)
Eur. Biophys. J.
, vol.31
, pp. 268-274
-
-
Goody, R.S.1
Hofmann-Goody, W.2
-
10
-
-
0032560850
-
The structural basis of the activation of Ras by Sos
-
Boriack-Sjodin, P. A., Margarit, S. M., Bar-Sagi, D. & Kuriyan, J. The structural basis of the activation of Ras by Sos. Nature 394, 337-343 (1998).
-
(1998)
Nature
, vol.394
, pp. 337-343
-
-
Boriack-Sjodin, P.A.1
Margarit, S.M.2
Bar-Sagi, D.3
Kuriyan, J.4
-
11
-
-
0032538317
-
Structural basis for activation of ARF GTPase: Mechanisms of guanine nucleotide exchange and GTP-myristoyl switching
-
Goldberg, J. Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching. Cell 95, 237-248 (1998).
-
(1998)
Cell
, vol.95
, pp. 237-248
-
-
Goldberg, J.1
-
12
-
-
0034619877
-
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
-
Worthylakej D. K., Rossman, K. L. & Sondek, J. Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature 408, 682-688 (2000).
-
(2000)
Nature
, vol.408
, pp. 682-688
-
-
Worthylakej, D.K.1
Rossman, K.L.2
Sondek, J.3
-
13
-
-
0035917523
-
Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)
-
Renault, L., Kuhlmann, J., Henkel, A. & Wittinghofer, A. Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). Cell 105, 245-255 (2001).
-
(2001)
Cell
, vol.105
, pp. 245-255
-
-
Renault, L.1
Kuhlmann, J.2
Henkel, A.3
Wittinghofer, A.4
-
14
-
-
0042266415
-
Arfand its many interactors
-
Nie, Z., Hirsch, D. S. & Randazzo, P. A. Arfand its many interactors. Curr. Opin. Cell Biol. 15, 396-404 (2003).
-
(2003)
Curr. Opin. Cell Biol.
, vol.15
, pp. 396-404
-
-
Nie, Z.1
Hirsch, D.S.2
Randazzo, P.A.3
-
15
-
-
0039818755
-
2+ and the β-phosphate to destabilize GDP on ARF1
-
2+ and the β-phosphate to destabilize GDP on ARF1. EMBO J. 17, 3651-3659 (1998).
-
(1998)
EMBO J.
, vol.17
, pp. 3651-3659
-
-
Beraud-Dufour, S.1
-
16
-
-
0035834388
-
The guanine nucleotide-binding switch in three dimensions
-
Vetter, I. R. & Wittinghofer, A. The guanine nucleotide-binding switch in three dimensions. Science 294, 1299-1304 (2001).
-
(2001)
Science
, vol.294
, pp. 1299-1304
-
-
Vetter, I.R.1
Wittinghofer, A.2
-
17
-
-
0036866606
-
Arf, Arl, Arp and Sar proteins: A family of GTP-binding proteins with a structural device for 'front-back' communication
-
Pasqualato, S., Renault, L. & Cherfils, J. Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication. EMBO Rep. 3, 1035-1041 (2002).
-
(2002)
EMBO Rep.
, vol.3
, pp. 1035-1041
-
-
Pasqualato, S.1
Renault, L.2
Cherfils, J.3
-
18
-
-
0028556994
-
Structure of the human ADP-ribosylation factor I complexed with GDP
-
Amor, J. C., Harrison, D. H., Kahn, R. A. & Ringe, D. Structure of the human ADP-ribosylation factor I complexed with GDP. Nature 372, 704-708 (1994).
-
(1994)
Nature
, vol.372
, pp. 704-708
-
-
Amor, J.C.1
Harrison, D.H.2
Kahn, R.A.3
Ringe, D.4
-
19
-
-
0142097228
-
Structure of Arf6-GDP suggests a basis for guanine nucleotide exchange factors specificity
-
Menetrey, J., Macia, E., Pasqualato, S., Franco, M. & Cherfils, J. Structure of Arf6-GDP suggests a basis for guanine nucleotide exchange factors specificity. Nature Struct. Biol. 7, 466-469 (2000).
-
(2000)
Nature Struct. Biol.
, vol.7
, pp. 466-469
-
-
Menetrey, J.1
Macia, E.2
Pasqualato, S.3
Franco, M.4
Cherfils, J.5
-
20
-
-
0030891289
-
N-terminnal hydrophobic residues of the G-protein ADP-ribosylation factor-1 insert into membrane phospholipids upon GDP to GTP exchange
-
Antonny, B., Beraud-Dufour, S., Chardin, P. & Chabre, M. N-terminnal hydrophobic residues of the G-protein ADP-ribosylation factor-1 insert into membrane phospholipids upon GDP to GTP exchange. Biochemistry 36, 4675-4684 (1997).
-
(1997)
Biochemistry
, vol.36
, pp. 4675-4684
-
-
Antonny, B.1
Beraud-Dufour, S.2
Chardin, P.3
Chabre, M.4
-
21
-
-
0033950864
-
Turning on ARF: The Sec7 family of guanine-nucleotide-exchange factors
-
Jackson, C. L. & Casanova, J. E. Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors. Trends Cell Biol. 10, 60-67 (2000).
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 60-67
-
-
Jackson, C.L.1
Casanova, J.E.2
-
22
-
-
0032485074
-
Structure of the Sec7 domain of the Arf exchange factor ARNO
-
Cherfils, J. et al. Structure of the Sec7 domain of the Arf exchange factor ARNO. Nature 392, 101-105 (1998).
-
(1998)
Nature
, vol.392
, pp. 101-105
-
-
Cherfils, J.1
-
23
-
-
0033529249
-
p200 ARF-GEP1: A Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A
-
Mansour, S. J. et al. p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A. Proc. Natl Acad. Sci. USA 96, 7968-7973 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7968-7973
-
-
Mansour, S.J.1
-
24
-
-
0033644364
-
Brefeldin A revealing the fundamental principles governing membrane dynamics and protein transport
-
Jackson, C. L. Brefeldin A revealing the fundamental principles governing membrane dynamics and protein transport. Subcell. Biochem. 34, 233-272 (2000).
-
(2000)
Subcell. Biochem.
, vol.34
, pp. 233-272
-
-
Jackson, C.L.1
-
25
-
-
0033998897
-
Elucidation of strict structural requirements of brefeldin A as an inducer of differentiation and apoptosis
-
Zhu, J. W. et al. Elucidation of strict structural requirements of brefeldin A as an inducer of differentiation and apoptosis. Bioorg. Med. Chem. 8, 455-463 (2000).
-
(2000)
Bioorg. Med. Chem.
, vol.8
, pp. 455-463
-
-
Zhu, J.W.1
-
26
-
-
0029844904
-
A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains
-
Chardin, P. et al. A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains. Nature 384, 481-484 (1996).
-
(1996)
Nature
, vol.384
, pp. 481-484
-
-
Chardin, P.1
-
27
-
-
0033549576
-
GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5
-
Claude, A. et al. GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5. J. Cell Biol. 146, 71-84 (1999).
-
(1999)
J. Cell Biol.
, vol.146
, pp. 71-84
-
-
Claude, A.1
-
28
-
-
0033937941
-
Regulators and effectors of the ARF GTPases
-
Donaldson, J. G. & Jackson, C. L. Regulators and effectors of the ARF GTPases. Curr. Opin. Cell Biol. 12, 475-482 (2000).
-
(2000)
Curr. Opin. Cell Biol.
, vol.12
, pp. 475-482
-
-
Donaldson, J.G.1
Jackson, C.L.2
-
29
-
-
0142211351
-
Multiple roles for Arf6: Sorting, structuring, and signaling at the plasma membrane
-
Donaldson, J. G. Multiple roles for Arf6: Sorting, structuring, and signaling at the plasma membrane. J. Biol. Chem. 11, 41573-41576 (2003).
-
(2003)
J. Biol. Chem.
, vol.11
, pp. 41573-41576
-
-
Donaldson, J.G.1
-
30
-
-
0033049656
-
Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors
-
Sata, M., Moss, J. & Vaughan, M. Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors. Proc. Natl Acad. Sci. USA 96, 2752-2757 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2752-2757
-
-
Sata, M.1
Moss, J.2
Vaughan, M.3
-
31
-
-
0035788652
-
A point mutation in an unusual Sec7 domain is linked to brefeldin A resistance in a Plasmodium falciparum line generated by drug selection
-
Baumgartner, F., Wick, S., Paprotka, K., Zauner, S. & Lingelbach, K. A point mutation in an unusual Sec7 domain is linked to brefeldin A resistance in a Plasmodium falciparum line generated by drug selection. Mol. Microbiol. 41, 1151-1158 (2001).
-
(2001)
Mol. Microbiol.
, vol.41
, pp. 1151-1158
-
-
Baumgartner, F.1
Wick, S.2
Paprotka, K.3
Zauner, S.4
Lingelbach, K.5
-
32
-
-
0034730123
-
Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain
-
Robineau, S., Chabre, M. & Antonny, B. Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain. Proc. Natl Acad. Sci. USA 97, 9913-9918 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9913-9918
-
-
Robineau, S.1
Chabre, M.2
Antonny, B.3
-
33
-
-
0033574449
-
Brefeldin A: The advantage of being uncompetitive
-
Chardin, P. & McCormick, F. Brefeldin A: the advantage of being uncompetitive. Cell 97, 153-155 (1999).
-
(1999)
Cell
, vol.97
, pp. 153-155
-
-
Chardin, P.1
McCormick, F.2
-
34
-
-
0040411317
-
Dual interaction of ADP ribosylation factor 1 with Sec7 domain and with lipid membranes during catalysis of guanine nucleotide exchange
-
Beraud-Dufour, S., Paris, S., Chabre, M. & Antonny, B. Dual interaction of ADP ribosylation factor 1 with Sec7 domain and with lipid membranes during catalysis of guanine nucleotide exchange. J. Biol. Chem. 274, 37629-37636 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37629-37636
-
-
Beraud-Dufour, S.1
Paris, S.2
Chabre, M.3
Antonny, B.4
-
35
-
-
0037133511
-
Mechanism of domain closure of Sec7 domains and role in BFA sensitivity
-
Renault, L., Christova, P., Guibert, B., Pasqualato, S. & Cherfils, J. Mechanism of domain closure of Sec7 domains and role in BFA sensitivity. Biochemistry 41, 3605-3612 (2002).
-
(2002)
Biochemistry
, vol.41
, pp. 3605-3612
-
-
Renault, L.1
Christova, P.2
Guibert, B.3
Pasqualato, S.4
Cherfils, J.5
-
36
-
-
0015167768
-
Structure of brefeldin A
-
Weber, H. P., Hauser, D. & Sigg, H. P. Structure of brefeldin A. Helv. Chim. Acta 54, 2763-2766 (1971).
-
(1971)
Helv. Chim. Acta
, vol.54
, pp. 2763-2766
-
-
Weber, H.P.1
Hauser, D.2
Sigg, H.P.3
-
37
-
-
0029051356
-
Cytotoxicity of brefeldin A correlates with its inhibitory effect on membrane binding of COP coat proteins
-
Torii, S. et al. Cytotoxicity of brefeldin A correlates with its inhibitory effect on membrane binding of COP coat proteins. J. Biol. Chem. 270, 11574-11580 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 11574-11580
-
-
Torii, S.1
-
38
-
-
0347385415
-
-
(ed. Kahn, R. A.) Ch. 3 (Kluwer Academic, Dordrecht, in the press)
-
Pasqualato, S., Renault, L. & Cherfils, J. in The ARF Book (ed. Kahn, R. A.) Ch. 3 (Kluwer Academic, Dordrecht, in the press).
-
The ARF Book
-
-
Pasqualato, S.1
Renault, L.2
Cherfils, J.3
-
39
-
-
0033636402
-
Small-molecule inhibitors of cell signaling
-
McCormick, F. Small-molecule inhibitors of cell signaling. Curr. Opin. Biotechnol. 11, 593-597 (2000).
-
(2000)
Curr. Opin. Biotechnol.
, vol.11
, pp. 593-597
-
-
McCormick, F.1
-
40
-
-
0037416221
-
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
-
Wurtele, M., Jclich-Ottmann, C., Wittinghofer, A. & Oecking, C. Structural view of a fungal toxin acting on a 14-3-3 regulatory complex. EMBO J. 22, 987-994 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 987-994
-
-
Wurtele, M.1
Jclich-Ottmann, C.2
Wittinghofer, A.3
Oecking, C.4
-
41
-
-
0029842109
-
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
-
Choi, J., Chen, J., Schreiber, S. L. & Clardy, J. Structure of the FKBP 12-rapamycin complex interacting with the binding domain of human FRAP. Science 273, 239-242 (1996).
-
(1996)
Science
, vol.273
, pp. 239-242
-
-
Choi, J.1
Chen, J.2
Schreiber, S.L.3
Clardy, J.4
-
42
-
-
0035798244
-
Structural mimicry of DH domains by Arfaptin suggests a model for the recognition of Rac-GDP by its guanine nucleotide exchange factors
-
Cherfils, J. Structural mimicry of DH domains by Arfaptin suggests a model for the recognition of Rac-GDP by its guanine nucleotide exchange factors. FEBS Lett. 507, 280-284 (2001).
-
(2001)
FEBS Lett.
, vol.507
, pp. 280-284
-
-
Cherfils, J.1
-
43
-
-
0038311995
-
Ras family signaling: Therapeutic targeting
-
Cox, A. D. & Der, C. J. Ras family signaling: therapeutic targeting. Cancer Biol. Ther. 1, 599-606 (2002).
-
(2002)
Cancer Biol. Ther.
, vol.1
, pp. 599-606
-
-
Cox, A.D.1
Der, C.J.2
-
44
-
-
0037139607
-
The role of Rho GTPases in disease development
-
Boettner, B. & Van Aelst, L. The role of Rho GTPases in disease development. Gene 286, 155-174 (2002).
-
(2002)
Gene
, vol.286
, pp. 155-174
-
-
Boettner, B.1
Van Aelst, L.2
-
45
-
-
84889120137
-
Improved methods for building protein models in electron density maps and the location of errors in these models
-
Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119 (1991).
-
(1991)
Acta Crystallogr. A
, vol.47
, pp. 110-119
-
-
Jones, T.A.1
Zou, J.Y.2
Cowan, S.W.3
Kjeldgaard, M.4
|