메뉴 건너뛰기




Volumn 1029, Issue , 2004, Pages 115-131

Insights into the mechanism of oral tolerance derived from the study of models of mucosal inflammation

Author keywords

Cell transfer colitis; IL 10; Regulatory T cells; TGF ; TNBS colitis

Indexed keywords

AUTOANTIGEN; INTERLEUKIN 10; MICROORGANISM PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRINITROBENZENESULFONIC ACID;

EID: 14544279695     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1309.029     Document Type: Conference Paper
Times cited : (15)

References (39)
  • 1
    • 0038744423 scopus 로고    scopus 로고
    • Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis
    • KRAJINA, T., F. LEITHAUSER, P. MOLLER, et al. 2003. Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis. Eur. J. Immunol. 33: 1073-1083.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 1073-1083
    • Krajina, T.1    Leithauser, F.2    Moller, P.3
  • 2
    • 0028179230 scopus 로고
    • low CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity
    • low CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med. 179: 589-600.
    • (1994) J. Exp. Med. , vol.179 , pp. 589-600
    • Powrie, F.1    Correa-Oliveira, R.2    Mauze, S.3
  • 3
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • OPPMANN, B., R. LESLEY, B. BLOM, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-725.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 4
    • 0037446531 scopus 로고    scopus 로고
    • Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells
    • MOTTET, C., H.H. UHLIG & F. POWRIE. 2003. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J. Immunol. 170: 3939-3943.
    • (2003) J. Immunol. , vol.170 , pp. 3939-3943
    • Mottet, C.1    Uhlig, H.H.2    Powrie, F.3
  • 5
    • 0037243827 scopus 로고    scopus 로고
    • CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms
    • MALLOY, K.J., L. SALAUN, R. CAHILL, et al. 2003. CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 197: 111-119.
    • (2003) J. Exp. Med. , vol.197 , pp. 111-119
    • Malloy, K.J.1    Salaun, L.2    Cahill, R.3
  • 6
    • 0035180065 scopus 로고    scopus 로고
    • Immunologic tolerance maintained by CD25+CD4+ regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
    • SAKAGUCHI, S., N. SAKAGUCHI, J. SHIMIZU, et al. 2001. Immunologic tolerance maintained by CD25+CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182: 18-32.
    • (2001) Immunol. Rev. , vol.182 , pp. 18-32
    • Sakaguchi, S.1    Sakaguchi, N.2    Shimizu, J.3
  • 7
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation
    • READ, S., V. MALMSTROM & F. POWRIE. 2000. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation. J. Exp. Med. 192: 295-302.
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 8
    • 0242580070 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells cure murine colitis: The role of IL-10, TGF-β, and CTLA-4
    • LIU, H., B. HU, D. XU, et al. 2003. CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-β, and CTLA-4. J. Immunol. 171: 5012-5017.
    • (2003) J. Immunol. , vol.171 , pp. 5012-5017
    • Liu, H.1    Hu, B.2    Xu, D.3
  • 9
    • 0035337241 scopus 로고    scopus 로고
    • CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice
    • MALMSTROM, V., D. SHIPTON, B. SINGH, et al. 2001. CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J. Immunol. 166: 6972-6981.
    • (2001) J. Immunol. , vol.166 , pp. 6972-6981
    • Malmstrom, V.1    Shipton, D.2    Singh, B.3
  • 10
    • 0034924028 scopus 로고    scopus 로고
    • Loss of transforming growth factor beta signaling in the intestine contributes to tissue injury in inflammatory bowel disease
    • HAHM, K.B., Y.H. IM, T.W. PARKS, et al. 2001. Loss of transforming growth factor beta signaling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 49: 164-165.
    • (2001) Gut , vol.49 , pp. 164-165
    • Hahm, K.B.1    Im, Y.H.2    Parks, T.W.3
  • 11
    • 0037331535 scopus 로고    scopus 로고
    • Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells
    • BECK, P.L., I.M. ROSENBERG, R.J. XAVIER, et al. 2003. Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am. J. Pathol. 162: 597-608.
    • (2003) Am. J. Pathol. , vol.162 , pp. 597-608
    • Beck, P.L.1    Rosenberg, I.M.2    Xavier, R.J.3
  • 12
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGF-β signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • GORELIK, L. & R. A. FLAVELL. 2000. Abrogation of TGF-β signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12: 171-181.
    • (2000) Immunity , vol.12 , pp. 171-181
    • Gorelik, L.1    Flavell, R.A.2
  • 13
    • 1642577126 scopus 로고    scopus 로고
    • TGF-β1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    • NAKAMURA, K., A. KITANI, I. FUSS, et al. 2004. TGF-β1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J. Immunol. 172: 834-842.
    • (2004) J. Immunol. , vol.172 , pp. 834-842
    • Nakamura, K.1    Kitani, A.2    Fuss, I.3
  • 14
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • NAKAMURA, K., A. KITANI & W. STROBER. 2001. Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 194: 629-644.
    • (2001) J. Exp. Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 15
    • 0037099613 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
    • PICCIRILLO, C.A., J.J. LETTERIO, A.M. THORNTON, et al. 2002. CD4+CD25+ regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J. Exp. Med. 196: 237-246.
    • (2002) J. Exp. Med. , vol.196 , pp. 237-246
    • Piccirillo, C.A.1    Letterio, J.J.2    Thornton, A.M.3
  • 16
    • 0035133290 scopus 로고    scopus 로고
    • Enteric bacterial antigens activate CD4+ T cells from scid mice with inflammatory bowel disease
    • BRIMNES, J., J. REIMANN, M. NISSEN, et al. 2001. Enteric bacterial antigens activate CD4+ T cells from scid mice with inflammatory bowel disease. Eur. J. Immunol. 31: 23-31.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 23-31
    • Brimnes, J.1    Reimann, J.2    Nissen, M.3
  • 17
    • 0029552652 scopus 로고
    • Genetic and spontaneous models of inflammatory bowel disease in rodents: Evidence for abnormalities in mucosal immune regulation
    • POWRIE, F. & M.W. LEACH. 1995. Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation. Ther. Immunol. 2: 115-123.
    • (1995) Ther. Immunol. , vol.2 , pp. 115-123
    • Powrie, F.1    Leach, M.W.2
  • 18
    • 1542618118 scopus 로고    scopus 로고
    • Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    • MACPHERSON, A.J. & T. UHR. 2004. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303: 1662-1665.
    • (2004) Science , vol.303 , pp. 1662-1665
    • MacPherson, A.J.1    Uhr, T.2
  • 19
    • 0141835046 scopus 로고    scopus 로고
    • Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
    • BECKER, C., S. WIRTZ, M. BLESSING, et al. 2003. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J. Clin. Invest. 112: 693-706.
    • (2003) J. Clin. Invest. , vol.112 , pp. 693-706
    • Becker, C.1    Wirtz, S.2    Blessing, M.3
  • 20
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-β induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    • FANTINI, M.C., C. BECKER, G. MONTELEONE, et al. 2004. Cutting edge: TGF-β induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 179: 5149-5153.
    • (2004) J. Immunol. , vol.179 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3
  • 21
    • 3242754344 scopus 로고    scopus 로고
    • Tolerance induced by inhaled antigen involves CD4+ T cells expressing membrane-bound TGF-β and FOXP3
    • OUSTROUKHOVA, M., C. SEGUIN-DEVAUX, T.B. ORISS, et al. 2004. Tolerance induced by inhaled antigen involves CD4+ T cells expressing membrane-bound TGF-β and FOXP3. J. Clin. Invest. 114: 28-38.
    • (2004) J. Clin. Invest. , vol.114 , pp. 28-38
    • Oustroukhova, M.1    Seguin-Devaux, C.2    Oriss, T.B.3
  • 22
    • 1242290580 scopus 로고    scopus 로고
    • Natural and induced CD4+CD25+ cells educate CD4+CD25-cells to develop suppressive activity: The role of IL-2, TGF-β, and IL-10
    • ZHENG, S.G., J.H. WANG, J.D. GRAY, et al. 2004. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-β, and IL-10. J. Immunol. 172: 5213-5221.
    • (2004) J. Immunol. , vol.172 , pp. 5213-5221
    • Zheng, S.G.1    Wang, J.H.2    Gray, J.D.3
  • 23
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • NEURATH, M.F., I. FUSS, B.L. KELSALL, et al. 1995. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182: 1281-1290.
    • (1995) J. Exp. Med. , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3
  • 24
    • 0036327730 scopus 로고    scopus 로고
    • Experimental murine colitis is regulated by two genetic loci, including one on chromosome 11 that regulates IL-12 responses
    • BOUMA, G., A. KAUSHIVA & W. STROBER. 2002. Experimental murine colitis is regulated by two genetic loci, including one on chromosome 11 that regulates IL-12 responses. Gastroenterology 123: 554-565.
    • (2002) Gastroenterology , vol.123 , pp. 554-565
    • Bouma, G.1    Kaushiva, A.2    Strober, W.3
  • 25
    • 0030029222 scopus 로고    scopus 로고
    • Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion
    • STUBER, E., W. STROBER & M. NEURATH. 1996. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J. Exp. Med. 183: 693-698.
    • (1996) J. Exp. Med. , vol.183 , pp. 693-698
    • Stuber, E.1    Strober, W.2    Neurath, M.3
  • 26
    • 0029995799 scopus 로고    scopus 로고
    • Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance
    • NEURATH, M.F., I. FUSS, B.L. KELSALL, et al. 1996. Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance. J. Exp. Med. 183: 2605-2616.
    • (1996) J. Exp. Med. , vol.183 , pp. 2605-2616
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3
  • 27
    • 0037080032 scopus 로고    scopus 로고
    • The interrelated roles of TGF-β and IL-10 in the regulation of experimental colitis
    • FUSS, I.J., M. BOIRIVANT, B. LACY, et al. The interrelated roles of TGF-β and IL-10 in the regulation of experimental colitis. J. Immunol. 168: 900-908.
    • J. Immunol. , vol.168 , pp. 900-908
    • Fuss, I.J.1    Boirivant, M.2    Lacy, B.3
  • 29
    • 0033584234 scopus 로고    scopus 로고
    • Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells
    • IWASAKI, A. & B.L. KELSALL. 1999. Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J. Exp. Med. 190: 229-239.
    • (1999) J. Exp. Med. , vol.190 , pp. 229-239
    • Iwasaki, A.1    Kelsall, B.L.2
  • 30
    • 0038783387 scopus 로고    scopus 로고
    • Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: Control by CD4+ regulatory T cells and IL-10
    • ASSEMAN, C., S. READ & F. POWRIE. 2003. Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10. J. Immunol. 171: 971-978.
    • (2003) J. Immunol. , vol.171 , pp. 971-978
    • Asseman, C.1    Read, S.2    Powrie, F.3
  • 31
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • GROUX, H., A. O'GARRA, M. BIGLER, et al. 1997. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389: 737-742.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    O'garra, A.2    Bigler, M.3
  • 32
    • 0037136284 scopus 로고    scopus 로고
    • Bacteria-triggered CD4+ T regulatory cells suppress Helicobacter hepaticus-induced colitis
    • KULLBERG, M.C., D. JANKOVIC, P.L. GORELICK, et al. 2002. Bacteria-triggered CD4+ T regulatory cells suppress Helicobacter hepaticus-induced colitis. J. Exp. Med. 196: 505-515.
    • (2002) J. Exp. Med. , vol.196 , pp. 505-515
    • Kullberg, M.C.1    Jankovic, D.2    Gorelick, P.L.3
  • 33
    • 0035879091 scopus 로고    scopus 로고
    • Regulation of TGF-β responses during T cell activation is modulated by IL-10
    • COTTREZ, F. & H. GROUX. 2001. Regulation of TGF-β responses during T cell activation is modulated by IL-10. J. Immunol. 167: 773-778.
    • (2001) J. Immunol. , vol.167 , pp. 773-778
    • Cottrez, F.1    Groux, H.2
  • 34
    • 0030611757 scopus 로고    scopus 로고
    • Identification of Smad7, a TGF-β-inducible antagonist of TGF-β signaling
    • NAKAO, A., M. AFRAKHTE, A. MOREN, et al. 1997. Identification of Smad7, a TGF-β-inducible antagonist of TGF-β signaling. Nature 389: 549-551.
    • (1997) Nature , vol.389 , pp. 549-551
    • Nakao, A.1    Afrakhte, M.2    Moren, A.3
  • 35
    • 0032526354 scopus 로고    scopus 로고
    • Factors involved in the differentiation of TGF-β-producing cells from naive CD4+ T cells: IL-4 and IFNγ have opposing effects, while TGF-β positively regulates its own production
    • SEDER, R.A., T. MARTH, M.C. SIEVE, et al. 1998. Factors involved in the differentiation of TGF-β-producing cells from naive CD4+ T cells: IL-4 and IFNγ have opposing effects, while TGF-β positively regulates its own production. J. Immunol. 160: 5719-5728.
    • (1998) J. Immunol. , vol.160 , pp. 5719-5728
    • Seder, R.A.1    Marth, T.2    Sieve, M.C.3
  • 36
    • 0034600789 scopus 로고    scopus 로고
    • Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-β1 plasmid: TGF-β1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor β2 chain down-regulation
    • KITANI, A., I.J. FUSS, K. NAKAMURA, et al. 2000. Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-β1 plasmid: TGF-β1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor β2 chain down-regulation. J. Exp. Med. 192: 41-52.
    • (2000) J. Exp. Med. , vol.192 , pp. 41-52
    • Kitani, A.1    Fuss, I.J.2    Nakamura, K.3
  • 37
    • 0142219250 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis
    • KITANI, A., I. FUSS, K. NAKAMURA, et al. 2003. Transforming growth factor (TGF)-β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis. J. Exp. Med. 198: 1179-1188.
    • (2003) J. Exp. Med. , vol.198 , pp. 1179-1188
    • Kitani, A.1    Fuss, I.2    Nakamura, K.3
  • 38
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • HORI, S., T. NOMURA & S. SAKAGUCHI. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 39
    • 0346888498 scopus 로고    scopus 로고
    • Control of autoimmunity by naturally arising regulatory CD4+ T cells
    • HORI, S., T. TAKAHASHI & S. SAKAGUCHI. 2003. Control of autoimmunity by naturally arising regulatory CD4+ T cells. Adv. Immunol. 81: 331-371.
    • (2003) Adv. Immunol. , vol.81 , pp. 331-371
    • Hori, S.1    Takahashi, T.2    Sakaguchi, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.