Characterization of a Naphthalene Derivative Inhibitor of Retroviral Integrases

AIDS Research and Human Retroviruses

Volumn 20, Issue 2, 2004, Pages 135-144

  Daniel, R ^a   Myers, C B ^a   Kulkosky, J ^b   Taganov, K ^a   Greger, J G ^a   Merkel, G ^a   Weber, I T ^c   Harrison, R W ^c   Skalka, A M ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b CHESTNUT HILL COLLEGE   (United States)

^c GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,8 DIBROMO 7 AMINO 4 HYDROXY 2 NAPHTHALENESULFONIC ACID; INTEGRASE; NAPHTHALENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; AVIAN SARCOMA VIRUS; CATALYSIS; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REPORTER GENE; RETROVIRUS; VIRUS REPLICATION;

AVIAN SARCOMA VIRUSES; BASE SEQUENCE; DNA, VIRAL; HELA CELLS; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; INTEGRASE INHIBITORS; NAPHTHALENES; TRANSDUCTION, GENETIC; VIRUS REPLICATION;

EID: 1442348212     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922204773004842     Document Type: Article

References (24)

1. Coffin JM, Hughes SH, and Varmus HE: The Retroviruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1997.
2. Katz RA, Gravuer K, and Skalka AM: A preferred target DNA structure for retroviral integrase in vitro. J Biol Chem 1998;273: 24190-24195.
3. Goldgur Y, Craigie R, Cohen GH, et al.: Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design. Proc Natl Acad Sci USA 1999;96: 13040-13043.
4. Hazuda DJ, Felock P, Witmer M, et al.: Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 2000;287:646-650.
5. Yoshinaga T, Sato A, Fujishita T, and Fujiwara T: In vitro activity of a new HIV-1 integrase inhibitor in clinical development. Presented at the 9th Conference on Retroviruses and Opportunistic Infections, Seattle, WA, 2002.
6. Lubkowski J, Yang F, Alexandratos J, et al.: Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor. Proc Natl Acad Sci USA 1998;95: 4831-4836.
7. Katz RA, DeCandeloro P, Kukolj G, and Skalka AM: Role of DNA end distortion in catalysis by avian sarcoma virus integrase. J Biol Chem 2001;276:34213-34220.
8. Katz RA, Merkel G, and Skalka AM: Targeting of retroviral integrase by fusion to a heterologous DNA binding domain: In vitro activities and incorporation of a fusion protein into viral particles. Virology 1996;217:178-190.
9. Asante-Appiah E and Skalka AM: A meta-induced conformational change and activation of HIV-1 integrase. J Biol Chem 1997;272: 16196-16205.
10. Katz RA, Kotler M, and Skalka AM: Cis-acting intron mutations that affect the efficiency of avian retroviral RNA splicing: Implication for mechanisms of control. J Virol 1988;62:2686-2695.
11. Naldini L, Blömer U, Gallay P, et al.: In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996;272:263-267.
12. Zhang H, Dornadula G, Beumont M, et al.: Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy. N Engl J Med 1998;339:1803-1809.
13. Vandegraaff N, Kumar R, Burrell CJ, and Li P: Kinetics of human immunodeficiency virus type 1 (HIV) DNA integration in acutely infected cells as determined using a novel assay for detection of integrated HIV DNA. J Virol 2001;75:11253-11260.
14. Vandegraaff N, Kumar R, Hocking H, et al.: Specific inhibition of human immunodeficiency virus type 1 (HIV-1) integration in cell culture; putative inhibitors of HIV-1 integrase. Antimicrob Agents Chemother 2001;45:2510-2516.
15. Courcoul M, Patience C, Rey F, et al.: Peripheral blood mononuclear cells produce normal amounts of defective Vif-human immunodeficiency virus type 1 particles which are restricted for the preretrotranscription steps. J Virol 1995;69:2068-2074.
16. Butler SL, Hansen MS, and Bushman FD: A quantitative assay for HIV DNA integration in vivo. Nat Med 2001;7:631-634.
17. Andrake MD and Skalka AM: Multimerization determinants reside in both the catalytic core and C terminus of avian sarcoma virus integrase. J Biol Chem 1995;270:29299-29306.
18. Neamati N, Lin Z, Karki RG, et al.: Metal-dependent inhibition of HIV-1 integrase. J Med Chem 2002;45:5661-5670.
19. Pommier Y and Neamati N: Inhibitors of human immunodeficiency virus integrase. In: Advances in Virus Research (Maramorosch K, Murphy FA, and Shatkin AJ, eds.), Vol. 52. Academic Press, San Diego, CA, 1999, pp. 427-448.
20. Rice WG, Schaeffer CA, Graham L, et al.: The site of antiviral actin of 3-nitrosobenzamide on the infectivity process of human immunodeficiency virus in human lymphocytes. Proc Natl Acad Sci USA 1993;90:9721-9724.
21. Katz RA and Skalka AM: Retroviral enzymes. Annu Rev Biochem 1994;63:133-173.
22. Wu X, Liu H, Xiao H, et al.: Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific intereactions with the nucleoprotein reverse transcription complex. J Virol 1999;73:2126-2135.
23. Lai L, Liu H, Wu X, and Kappes JC: Moloney murine leukemia virus integrase protein augments viral DNA synthesis in infected cells. J Virol 2001;75:11365-11372.
24. Nymark-McMahon MH, Beliakova-Bethell NS, Darlix J-L, Le Grive SF, and Sandmeyer SB: Ty3 integrase is required for initiation of reverse transcription. J Virol 2002;76:2804-2816.