Moloney murine leukemia virus integrase protein augments viral DNA synthesis in infected cells

Journal of Virology

Volumn 75, Issue 23, 2001, Pages 11365-11372

  Lai, L ^a   Liu, H ^a   Wu, X ^a   Kappes, J C ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA;

ARTICLE; DNA SYNTHESIS; GENE MUTATION; MOLONEY LEUKEMIA ONCOVIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRION; VIRUS INFECTION; VIRUS MUTANT;

BASE SEQUENCE; CELL LINE; DNA PRIMERS; DNA REPLICATION; DNA, VIRAL; HUMANS; INTEGRASES; MOLONEY MURINE LEUKEMIA VIRUS; MUTATION; VIRION;

EID: 0035169289     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.23.11365-11372.2001     Document Type: Article

References (34)

1. Transactivation of the minus-strand DNA transfer by nucleocapsid protein during reverse transcription of the retroviral genome
2. Analysis of human immunodeficiency virus type 1 integrase mutants
3. Expression of human immunodeficiency virus type 1 reverse transcriptase in trans during virion release and after infection
4. Integration
5. Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease
6. Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replication
7. Lentiviral vector transduction of hematopoietic stem cells that mediate long-term reconstitution of lethally irradiated mice
8. Analysis of mutant Moloney murine leukemia viruses containing linker insertion mutations in the 3′ region of pol
9. A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration
10. In vivo analysis of retroviral integrase structure and function
11. Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication
12. Kat: A high efficiency retroviral transduction system for primary human T lymphocytes
13. HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway
14. Human immunodeficiency virus type 1 nucleocapsid protein promotes efficient strand transfer and specific viral DNA synthesis by inhibiting TAR-dependent self-priming from minus-strand strong-stop DNA
15. Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection
16. Lys in vitro: Studies of viral RNA molecules mutated in regions that flank the primer binding site
17. Incorporation of functional human immunodeficiency virus type 1 integrase into virions independent of the Gag-Pol precursor protein
18. Targeting human immunodeficiency virus (HIV) type 2 integrase protein into HIV type 1
19. Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: Unusual phenotype of mutants in the zinc finger-like domain
20. Development and application of retroviral vectors
21. Mutations in non-conserved domains of Ty3 integrase affect multiple stages of the Ty3 life cycle
22. Extensive regions of pol are required for efficient human immunodeficiency virus polyprotein processing and particle maturation
23. Mutational analysis of the carboxy terminus of the Moloney murine leukemia virus integration protein
24. Analysis of mutations in the integration function of Moloney murine leukemia virus: Effects on DNA binding and cutting
25. Construction and analysis of deletion mutations in the pol gene of Moloney leukemia virus: A new viral function required for productive infection
26. Genetic analysis of the human immunodeficiency virus type 1 integrase protein
27. Synthesis, assembly, and processing of viral proteins
28. HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus
29. Retroviral virions and genomes
30. Human immunodeficiency virus type 1 integrase: Effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells
31. Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex
32. Functional RT and IN incorporated into HIV-1 particles independently of the Gag-Pol precursor protein
33. Targeting foreign proteins to human immunodeficiency virus particles via fusion with Vpr and Vpx
34. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors