Amino- and Carboxyl-Terminal Mutants of Presenilin 1 Cause Neuronal Cell Death Through Distinct Toxic Mechanisms: Study of 27 Different Presenilin 1 Mutants

Journal of Neuroscience Research

Volumn 75, Issue 3, 2004, Pages 417-428

  Hashimoto, Yuichi ^a   Tsukamoto, Emi ^a   Niikura, Takako ^a   Yamagishi, Yohichi ^a   Ishizaka, Miho ^a   Aiso, Sadakazu ^a   Takashima, Akihiko ^b   Nishimoto, Ikuo ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Alzheimer's disease; Humanin; IGF I; NADPH oxidase; NOS

Indexed keywords

ACETOPHENONE DERIVATIVE; APOCYNIN; ENZYME INHIBITOR; HUMANIN; MEMBRANE PROTEIN; MUTANT PROTEIN; NEUROPROTECTIVE AGENT; NEUROTOXIN; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PRESENILIN 1; PROTEIN; PSEN1 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE INHIBITOR; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CELL DEATH; CHEMISTRY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; GENE MUTATION; GENETICS; IMMUNOBLOTTING; METABOLISM; MOUSE; MUTATION; NERVE CELL; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION;

ACETOPHENONES; ALZHEIMER DISEASE; ANIMALS; CELL DEATH; CELLS, CULTURED; ENZYME INHIBITORS; IMMUNOBLOTTING; INSULIN-LIKE GROWTH FACTOR I; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MUTATION; NADPH OXIDASE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NITRIC OXIDE SYNTHASE; PRESENILIN-1; PROTEINS;

EID: 0842312970     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10861     Document Type: Article

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