Structure-based design of cathepsin K inhibitors containing a benzyloxy- substituted benzoyl peptidomimetic

Journal of Medicinal Chemistry

Volumn 41, Issue 21, 1998, Pages 3923-3927

  Thompson, Scott K ^a   Smith, Ward W ^a   Zhao, Baoguang ^a   Halbert, Stacie M ^a   Tomaszek, Thaddeus A ^a   Tew, David G ^a   Levy, Mark A ^a,b   Janson, Cheryl A ^a   D'Alessio, Karla J ^a   McQueney, Michael S ^a   Kurdyla, Jeff ^a   Jones, Christopher S ^a   Desjarlais, Renee L ^a,c   Abdel Meguid, Sherin S ^a   Veber, Daniel F ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Dept of Preclinical Pharmacokin ^*  (United States)

^c JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 BENZYLOXYBENZOYL) 2' (N BENZYLOXYCARBONYL LEVO LEUCINYL)CARBOHYDRAZIDE; 2 (3 BENZYLOXYBENZOYL) 2' (N BENZYLOXYCARBONYL LEVO LEUCINYL)CARBOHYDRAZIDE; 2 (4 BENZYLOXYBENZOYL) 2' (N BENZYLOXYCARBONYL LEVO LEUCINYL)CARBOHYDRAZIDE; 2 BENZOYL 2' (N BENZYLOXYCARBONYL LEVO LEUCINYL)CARBOHYDARZIDE; CATHEPSIN K INHIBITOR; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BONE ATROPHY; DRUG STRUCTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BENZOATES; BINDING SITES; CATHEPSINS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15144343753     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980474x     Document Type: Article

References (8)

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