Molecular diversity, biological activity and common ground shared by both

Medicinal Chemistry Research

Volumn 8, Issue 4-5, 1998, Pages 206-218

  Coffen, David L ^a   Baldino, Carmen M ^a   Lange, Meinolf ^a   Tilton, Robert F ^a   Tu, Cheng ^a  

^a ARQULE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; ANTIVIRUS AGENT; CYSTEINE PROTEINASE INHIBITOR; DIAMIDE; INDOLE DERIVATIVE; ISOCYANATE; ISOTHIOCYANIC ACID; PROTEIN KINASE INHIBITOR; SERINE PROTEINASE INHIBITOR; UREA DERIVATIVE;

ARTICLE; AUTOIMMUNE DISEASE; CANCER; CHEMICAL REACTION; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; METABOLIC DISORDER; METHODOLOGY; PROTOZOAL INFECTION; THROMBOSIS; VALIDATION PROCESS; VIRUS INFECTION;

EID: 0031794981     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. For a recent discussion of this topic see Moos, W.H. in A Practical Guide to Combinatorial Chemistry; Czarnik, A.W., DeWitt, S.H., Eds.; American Chemical Society Publications, Washington, D.C., 1997 p. 1-16.
2. 10.
3. HTS in the context of combinatorial chemistry is reviewed by Craig, F.F., Ref. 1 p. 399-412.
4. For examples of virtual screening see (a) Zheng, Q.; Kyle, D.J.; Bioorg. Med. Chem. 1996, 4, 631-638. (b) Horvath, D.; J. Med. Chem. 1997, 40, 2412-2423.
5. For examples of virtual screening see (a) Zheng, Q.; Kyle, D.J.; Bioorg. Med. Chem. 1996, 4, 631-638. (b) Horvath, D.; J. Med. Chem. 1997, 40, 2412-2423.
6. Pearlman, R. S. Novel Software Tools for Addressing Chemical Diversity 1996, http://www.netsci.org/Science/Combichem/featureo8.html. Pickett, S. D.; Mason, J. S.; McLay, I. M. J. Chem. Inf. Comput. Sci. 1996, 36, 1214-1223. Clark, R. D. J. Chem. Inf. Comput. Sci. 1997, 37, 1181-1188. Kearsley, S. K.; Sallamack, S.; Fluder, E. M.; Andose, J. D.; Mosley, R. T.; Sheridan, R. P. J. Chem. Inf. Comput. Sci. 1996, 36, 118-127. Turner, D. B.; Tyrrell, S. M.; Willett, P. J. Chem. Inf. Comput. Sci. 1997, 37, 18-22. Cramer, R. D.; Clark, R. D. Patterson, D. E.; Ferguson, A. M. J. Med. Chem. 1996, 39, 3060-3069. Warr, W. A. Perspectives in Drug Discovery and Design 1997, 7/8 115-130, Kluwer Academic Publishers, Netherlands.
7. Pearlman, R. S. Novel Software Tools for Addressing Chemical Diversity 1996, http://www.netsci.org/Science/Combichem/featureo8.html. Pickett, S. D.; Mason, J. S.; McLay, I. M. J. Chem. Inf. Comput. Sci. 1996, 36, 1214-1223. Clark, R. D. J. Chem. Inf. Comput. Sci. 1997, 37, 1181-1188. Kearsley, S. K.; Sallamack, S.; Fluder, E. M.; Andose, J. D.; Mosley, R. T.; Sheridan, R. P. J. Chem. Inf. Comput. Sci. 1996, 36, 118-127. Turner, D. B.; Tyrrell, S. M.; Willett, P. J. Chem. Inf. Comput. Sci. 1997, 37, 18-22. Cramer, R. D.; Clark, R. D. Patterson, D. E.; Ferguson, A. M. J. Med. Chem. 1996, 39, 3060-3069. Warr, W. A. Perspectives in Drug Discovery and Design 1997, 7/8 115-130, Kluwer Academic Publishers, Netherlands.
8. Pearlman, R. S. Novel Software Tools for Addressing Chemical Diversity 1996, http://www.netsci.org/Science/Combichem/featureo8.html. Pickett, S. D.; Mason, J. S.; McLay, I. M. J. Chem. Inf. Comput. Sci. 1996, 36, 1214-1223. Clark, R. D. J. Chem. Inf. Comput. Sci. 1997, 37, 1181-1188. Kearsley, S. K.; Sallamack, S.; Fluder, E. M.; Andose, J. D.; Mosley, R. T.; Sheridan, R. P. J. Chem. Inf. Comput. Sci. 1996, 36, 118-127. Turner, D. B.; Tyrrell, S. M.; Willett, P. J. Chem. Inf. Comput. Sci. 1997, 37, 18-22. Cramer, R. D.; Clark, R. D. Patterson, D. E.; Ferguson, A. M. J. Med. Chem. 1996, 39, 3060-3069. Warr, W. A. Perspectives in Drug Discovery and Design 1997, 7/8 115-130, Kluwer Academic Publishers, Netherlands.
9. Pearlman, R. S. Novel Software Tools for Addressing Chemical Diversity 1996, http://www.netsci.org/Science/Combichem/featureo8.html. Pickett, S. D.; Mason, J. S.; McLay, I. M. J. Chem. Inf. Comput. Sci. 1996, 36, 1214-1223. Clark, R. D. J. Chem. Inf. Comput. Sci. 1997, 37, 1181-1188. Kearsley, S. K.; Sallamack, S.; Fluder, E. M.; Andose, J. D.; Mosley, R. T.; Sheridan, R. P. J. Chem. Inf. Comput. Sci. 1996, 36, 118-127. Turner, D. B.; Tyrrell, S. M.; Willett, P. J. Chem. Inf. Comput. Sci. 1997, 37, 18-22. Cramer, R. D.; Clark, R. D. Patterson, D. E.; Ferguson, A. M. J. Med. Chem. 1996, 39, 3060-3069. Warr, W. A. Perspectives in Drug Discovery and Design 1997, 7/8 115-130, Kluwer Academic Publishers, Netherlands.
10. Pearlman, R. S. Novel Software Tools for Addressing Chemical Diversity 1996, http://www.netsci.org/Science/Combichem/featureo8.html. Pickett, S. D.; Mason, J. S.; McLay, I. M. J. Chem. Inf. Comput. Sci. 1996, 36, 1214-1223. Clark, R. D. J. Chem. Inf. Comput. Sci. 1997, 37, 1181-1188. Kearsley, S. K.; Sallamack, S.; Fluder, E. M.; Andose, J. D.; Mosley, R. T.; Sheridan, R. P. J. Chem. Inf. Comput. Sci. 1996, 36, 118-127. Turner, D. B.; Tyrrell, S. M.; Willett, P. J. Chem. Inf. Comput. Sci. 1997, 37, 18-22. Cramer, R. D.; Clark, R. D. Patterson, D. E.; Ferguson, A. M. J. Med. Chem. 1996, 39, 3060-3069. Warr, W. A. Perspectives in Drug Discovery and Design 1997, 7/8 115-130, Kluwer Academic Publishers, Netherlands.
11. Pearlman, R. S. Novel Software Tools for Addressing Chemical Diversity 1996, http://www.netsci.org/Science/Combichem/featureo8.html. Pickett, S. D.; Mason, J. S.; McLay, I. M. J. Chem. Inf. Comput. Sci. 1996, 36, 1214-1223. Clark, R. D. J. Chem. Inf. Comput. Sci. 1997, 37, 1181-1188. Kearsley, S. K.; Sallamack, S.; Fluder, E. M.; Andose, J. D.; Mosley, R. T.; Sheridan, R. P. J. Chem. Inf. Comput. Sci. 1996, 36, 118-127. Turner, D. B.; Tyrrell, S. M.; Willett, P. J. Chem. Inf. Comput. Sci. 1997, 37, 18-22. Cramer, R. D.; Clark, R. D. Patterson, D. E.; Ferguson, A. M. J. Med. Chem. 1996, 39, 3060-3069. Warr, W. A. Perspectives in Drug Discovery and Design 1997, 7/8 115-130, Kluwer Academic Publishers, Netherlands.
12. Pearlman, R. S. Novel Software Tools for Addressing Chemical Diversity 1996, http://www.netsci.org/Science/Combichem/featureo8.html. Pickett, S. D.; Mason, J. S.; McLay, I. M. J. Chem. Inf. Comput. Sci. 1996, 36, 1214-1223. Clark, R. D. J. Chem. Inf. Comput. Sci. 1997, 37, 1181-1188. Kearsley, S. K.; Sallamack, S.; Fluder, E. M.; Andose, J. D.; Mosley, R. T.; Sheridan, R. P. J. Chem. Inf. Comput. Sci. 1996, 36, 118-127. Turner, D. B.; Tyrrell, S. M.; Willett, P. J. Chem. Inf. Comput. Sci. 1997, 37, 18-22. Cramer, R. D.; Clark, R. D. Patterson, D. E.; Ferguson, A. M. J. Med. Chem. 1996, 39, 3060-3069. Warr, W. A. Perspectives in Drug Discovery and Design 1997, 7/8 115-130, Kluwer Academic Publishers, Netherlands.
13. Rockwell, A., Melden, M., Copeland, R.A., Hardman, K., Decicco, C.P., DeGrado, W.F.; J. Am. Chem. Soc. 1996, 118, 10337-10338.
14. Lipinski, C.A.; Lombardo, F.; Dominy, B.W.; Feeney, P.J.; Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings, Advanced Drug Delivery Reviews 1997, 23, 3-25.
15. MDL Drug Data Report version 97.2.
16. Lüllman, H.; Mohr, K.; Ziegler, A.; Bieger, D.; Pocket Atlas of Pharmacology: Thieme Medical Publishers, Inc.: New York, 1993.
17. Maryanoff, B.E.; Qui, X.; Padmanabhan, K.P.; Tulinsky, A.; Almond, H.R., Jr; Andrade-Gordon, P.; Greco, M.N.; Kauffman, J.A.; Nicolaou, K.C.; Proc. Natl. Acad. Sci., USA 1993, 90, 8048-8052 Powers, J.C.; Li, Z.; Ortega-Vilain, A-C.; Patil, G.S.; Chu, D-L.; Foreman, J.E.; Eveleth, D.D.; J. Med. Chem. 1996, 39, 4089-4098.
18. Maryanoff, B.E.; Qui, X.; Padmanabhan, K.P.; Tulinsky, A.; Almond, H.R., Jr; Andrade-Gordon, P.; Greco, M.N.; Kauffman, J.A.; Nicolaou, K.C.; Proc. Natl. Acad. Sci., USA 1993, 90, 8048-8052 Powers, J.C.; Li, Z.; Ortega-Vilain, A-C.; Patil, G.S.; Chu, D-L.; Foreman, J.E.; Eveleth, D.D.; J. Med. Chem. 1996, 39, 4089-4098.
19. Baldino, C.M.; Casebier, D.S.; Caserta, J.; Slobodkin, G.; Tu, C.; Coffen, D.L.; Synlett 1997, 488-490.
20. Preliminary results obtained by Drs. Adrian Sheldon, Hong Cheng and Ms. Marsha Cullinane using commercially sourced plasmin and cruzain provided by Prof. Charles Craik, UCSF.
21. th National ACS Meeting Abstracts 1998, MEDI 167,169. See Also U.S. Patent 5,656,654, 1997, assigned to Farmitalia Carlo Erba.
22. th National ACS Meeting Abstracts 1998, MEDI 167,169. See Also U.S. Patent 5,656,654, 1997, assigned to Farmitalia Carlo Erba.
23. Fokas, D.; Ryan, W.J.; Casebier, D.S.; Coffen, D.L.; Tetrahedron Lett. 1998, 39, 2235-2238.
24. Hansen, C. W.; Ann. Chim.; (Paris) 1924, 10, 97-134. Elliott, I. W.; Rivers, P.; J. Org. Chem. 1964, 29, 2438-2440.
25. Hansen, C. W.; Ann. Chim.; (Paris) 1924, 10, 97-134. Elliott, I. W.; Rivers, P.; J. Org. Chem. 1964, 29, 2438-2440.
26. Arumugam, V.; Routledge, A.; Abell, C.; Balasubramanian, S.; Tetrahedron Lett., 1997, 38, 6473-6476.