메뉴 건너뛰기




Volumn 11, Issue 1, 2004, Pages 91-96

The severity of liver fibrosis is associated with high leptin levels in chronic Hepatitis C

Author keywords

Chronic hepatitis C; Leptin; Liver fibrosis

Indexed keywords

FERRITIN; GLUCOSE; LEPTIN; PROTHROMBIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

EID: 10744231005     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.2003.00483.x     Document Type: Article
Times cited : (84)

References (42)
  • 1
    • 0030933395 scopus 로고    scopus 로고
    • Natural history of liver fibrosis progression in patients with chronic hepatitis C
    • Poynard T, Bedossa P, Opolon P and the OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 1997; 349: 825-832.
    • (1997) Lancet , vol.349 , pp. 825-832
    • Poynard, T.1    Bedossa, P.2    Opolon, P.3
  • 3
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with non alcoholic steatohepatitis
    • Angulo P, Keach JC, Batts K, Lindor KD. Independent predictors of liver fibrosis in patients with non alcoholic steatohepatitis. Hepatology 1999; 30: 1356-1362.
    • (1999) Hepatology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Keach, J.C.2    Batts, K.3    Lindor, K.D.4
  • 5
    • 0026514433 scopus 로고
    • The histological features of chronic hepatitis C and autoimmune chronic hepatitis C: A comparative analysis
    • Bach N, Thung SN, Schaffner F. The histological features of chronic hepatitis C and autoimmune chronic hepatitis C: a comparative analysis. Hepatology 1992; 15: 572-577.
    • (1992) Hepatology , vol.15 , pp. 572-577
    • Bach, N.1    Thung, S.N.2    Schaffner, F.3
  • 6
    • 0027386603 scopus 로고
    • Pathological diagnosis of chronic hepatitis C: A multicenter comparative study with chronic hepatitis B
    • Lefkowitch JH, Schiff ER, Davis RL et al. Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B. Gastroenterology 1993; 104: 595-603.
    • (1993) Gastroenterology , vol.104 , pp. 595-603
    • Lefkowitch, J.H.1    Schiff, E.R.2    Davis, R.L.3
  • 8
    • 0032146915 scopus 로고    scopus 로고
    • Host- and disease-specific factors affecting steatosis in chronic hepatitis C
    • Czaja A, Carpenter HA, Santrach PJ, Moore SB. Host-and disease-specific factors affecting steatosis in chronic hepatitis C. J Hepatol 1998; 29: 198-206.
    • (1998) J Hepatol , vol.29 , pp. 198-206
    • Czaja, A.1    Carpenter, H.A.2    Santrach, P.J.3    Moore, S.B.4
  • 9
    • 0032866706 scopus 로고    scopus 로고
    • Steatosis and intrahepatic hepatitis C virus in chronic hepatitis
    • Fujie H, Yotsuyanagi H, Moriya K et al. Steatosis and intrahepatic hepatitis C virus in chronic hepatitis. J Med Virol 1999; 59: 141-145.
    • (1999) J Med Virol , vol.59 , pp. 141-145
    • Fujie, H.1    Yotsuyanagi, H.2    Moriya, K.3
  • 10
    • 0034987263 scopus 로고    scopus 로고
    • Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    • Adinolfi LE, Gambardella M, Andreana A, Tripodi MF, Utili R, Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001; 33: 1358-1364.
    • (2001) Hepatology , vol.33 , pp. 1358-1364
    • Adinolfi, L.E.1    Gambardella, M.2    Andreana, A.3    Tripodi, M.F.4    Utili, R.5    Ruggiero, G.6
  • 11
    • 0032924020 scopus 로고    scopus 로고
    • Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis
    • Hourigan LF, Macdonald GA, Purdie D et al. Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis. Hepatology 1999; 29: 1215-1219.
    • (1999) Hepatology , vol.29 , pp. 1215-1219
    • Hourigan, L.F.1    Macdonald, G.A.2    Purdie, D.3
  • 12
    • 0034950652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    • Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001; 121: 91-100.
    • (2001) Gastroenterology , vol.121 , pp. 91-100
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 14
    • 0036718166 scopus 로고    scopus 로고
    • Fatigue is associated with high circulating leptin levels in chronic hepatitis C
    • Piche T, Gelsi E, Schneider SM et al. Fatigue is associated with high circulating leptin levels in chronic hepatitis C. Gut 2002; 51: 434-439.
    • (2002) Gut , vol.51 , pp. 434-439
    • Piche, T.1    Gelsi, E.2    Schneider, S.M.3
  • 15
    • 0033943527 scopus 로고    scopus 로고
    • Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis
    • Testa R, Franceschini R, Gianninni E et al. Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis. J Hepatol 2000; 33: 33-37.
    • (2000) J Hepatol , vol.33 , pp. 33-37
    • Testa, R.1    Franceschini, R.2    Gianninni, E.3
  • 16
    • 0029860791 scopus 로고    scopus 로고
    • Modulation of insulin activities by leptin
    • Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996; 274: 1185-1188.
    • (1996) Science , vol.274 , pp. 1185-1188
    • Cohen, B.1    Novick, D.2    Rubinstein, M.3
  • 17
    • 0040381066 scopus 로고    scopus 로고
    • Leptin impairs metabolic actions of insulin in isolated rat adipocytes
    • Muller G, Ertl J, Gerl M, Prelbisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 1997; 138: 10585-10593.
    • (1997) J Biol Chem , vol.138 , pp. 10585-10593
    • Muller, G.1    Ertl, J.2    Gerl, M.3    Prelbisch, G.4
  • 18
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
    • Sanyal AJ, Campbell-Sergent C, Mirshahi F et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120: 1183-1192.
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sergent, C.2    Mirshahi, F.3
  • 19
    • 0032489223 scopus 로고    scopus 로고
    • Transdifferentiation of rat hepatic stellate cells results in leptin expression
    • Potter JJ, Womack L, Mezey E, Anania FA. Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem Biophys Res Commun 1998; 244: 178-182.
    • (1998) Biochem Biophys Res Commun , vol.244 , pp. 178-182
    • Potter, J.J.1    Womack, L.2    Mezey, E.3    Anania, F.A.4
  • 20
    • 0031711787 scopus 로고    scopus 로고
    • Leptin, obesity, and liver disease
    • Kaplan LM. Leptin, obesity, and liver disease. Gastroenterology 1998; 115: 997-1001.
    • (1998) Gastroenterology , vol.115 , pp. 997-1001
    • Kaplan, L.M.1
  • 21
    • 0036234147 scopus 로고    scopus 로고
    • Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat
    • Ikejima K, Takei Y, Honda H et al. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 2002; 122: 1399-1410.
    • (2002) Gastroenterology , vol.122 , pp. 1399-1410
    • Ikejima, K.1    Takei, Y.2    Honda, H.3
  • 22
    • 0029863684 scopus 로고    scopus 로고
    • Endotoxin and cytokine induce expression of leptin, the OB gene product, in hamster. A role for leptin in the anorexia of infection
    • Grunfeld C, Zhao C, Fuller J et al. Endotoxin and cytokine induce expression of leptin, the OB gene product, in hamster. A role for leptin in the anorexia of infection. J Clin Invest 1996; 97: 2152-2157.
    • (1996) J Clin Invest , vol.97 , pp. 2152-2157
    • Grunfeld, C.1    Zhao, C.2    Fuller, J.3
  • 23
    • 0031427384 scopus 로고    scopus 로고
    • Activation of tumor necrosis factor-alpha system in chronic hepatitis C virus infection
    • Nelson DR, Lim HL, Marousis CG et al. Activation of tumor necrosis factor-alpha system in chronic hepatitis C virus infection. Dig Dis Sci 1997; 42: 2487-2494.
    • (1997) Dig Dis Sci , vol.42 , pp. 2487-2494
    • Nelson, D.R.1    Lim, H.L.2    Marousis, C.G.3
  • 24
    • 0034676629 scopus 로고    scopus 로고
    • Cytokines in alcoholic and nonalcoolic steatohepatitis
    • Tilg H, Diehl AM. Cytokines in alcoholic and nonalcoolic steatohepatitis. N Engl J Med 2000; 343: 1467-1476.
    • (2000) N Engl J Med , vol.343 , pp. 1467-1476
    • Tilg, H.1    Diehl, A.M.2
  • 25
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α - and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α - and obesity-induced insulin resistance. Science 1996; 271: 665-668.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 26
    • 0036165809 scopus 로고    scopus 로고
    • Tumor necrosis factor α promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease
    • Valenti L, Fracanzani L, Dongiovanni P et al. Tumor necrosis factor α promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease. Gastroenterology 2002; 122: 274-280.
    • (2002) Gastroenterology , vol.122 , pp. 274-280
    • Valenti, L.1    Fracanzani, L.2    Dongiovanni, P.3
  • 27
    • 0028234491 scopus 로고
    • Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C
    • The French METAVIR cooperative study group. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. Hepatology 1994; 20: 15-20.
    • (1994) Hepatology , vol.20 , pp. 15-20
  • 28
    • 0033933140 scopus 로고    scopus 로고
    • Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3
    • Rubbia-Brandt L, Quadri R et al. Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3. J Hepatol 2000; 33: 106-115.
    • (2000) J Hepatol , vol.33 , pp. 106-115
    • Rubbia-Brandt, L.1    Quadri, R.2
  • 29
    • 0034068984 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: Association with obesity and insulin resistance, and influence of weight loss
    • Luyckx FH, Lefebvre PJ, Scheen AJ. Non-alcoholic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss. Diabetes Metab 2000; 26: 98-106.
    • (2000) Diabetes Metab , vol.26 , pp. 98-106
    • Luyckx, F.H.1    Lefebvre, P.J.2    Scheen, A.J.3
  • 30
    • 0023801758 scopus 로고
    • Alcohol like liver disease in nonalcoholics. A clinical and histological comparison with alcohol-induced liver injury
    • Diehl AM, Goodman Z, Ishak KG. Alcohol like liver disease in nonalcoholics. A clinical and histological comparison with alcohol-induced liver injury. Gastroenterology 1988; 95: 1056-1062.
    • (1988) Gastroenterology , vol.95 , pp. 1056-1062
    • Diehl, A.M.1    Goodman, Z.2    Ishak, K.G.3
  • 31
    • 0024336332 scopus 로고
    • Nonalcoholic steatohepatitis
    • Lee RG. Nonalcoholic steatohepatitis. Hum Pathol 1989; 20: 594-598.
    • (1989) Hum Pathol , vol.20 , pp. 594-598
    • Lee, R.G.1
  • 32
    • 0025178612 scopus 로고
    • The natural history of non-alcoholic steatohepatitis: A follow-up study of forty two patients for up to 21 years
    • Powell EE, Cooksley GE, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of non-alcoholic steatohepatitis: a follow-up study of forty two patients for up to 21 years Hepatology 1990; 11: 74-80.
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, G.E.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 34
    • 0034465579 scopus 로고    scopus 로고
    • Elevated bound leptin correlates with energy expenditure in cirrhotics
    • Ockenga J, Bischoff C, Tillmann HL et al. Elevated bound leptin correlates with energy expenditure in cirrhotics. Gastroenterology 2000; 119: 1656-1662.
    • (2000) Gastroenterology , vol.119 , pp. 1656-1662
    • Ockenga, J.1    Bischoff, C.2    Tillmann, H.L.3
  • 36
    • 0033023477 scopus 로고    scopus 로고
    • Increased circulating leptin in alcoholic cirrhosis: Relation to release and adiposal
    • Henriksen JH, Holst JJ, Moller S, Brinch K, Bendtsen F. Increased circulating leptin in alcoholic cirrhosis: relation to release and adiposal. Hepatology 1999; 29: 1818-1824.
    • (1999) Hepatology , vol.29 , pp. 1818-1824
    • Henriksen, J.H.1    Holst, J.J.2    Moller, S.3    Brinch, K.4    Bendtsen, F.5
  • 37
    • 0033762069 scopus 로고    scopus 로고
    • Leptin has no role in determining severity of steatosis and fibrosis in patients with chronic hepatitis C
    • Giannini E, Ceppa P, Botta F et al. Leptin has no role in determining severity of steatosis and fibrosis in patients with chronic hepatitis C. Am J Gastroenterol 2000; 95: 3211-3217.
    • (2000) Am J Gastroenterol , vol.95 , pp. 3211-3217
    • Giannini, E.1    Ceppa, P.2    Botta, F.3
  • 38
    • 0031965266 scopus 로고    scopus 로고
    • Leptin regulates proinflammatory immune response
    • Loffreda S, Yang SQ, Lin HZ et al. Leptin regulates proinflammatory immune response. FASEB J 1998; 12: 57-65.
    • (1998) FASEB J , vol.12 , pp. 57-65
    • Loffreda, S.1    Yang, S.Q.2    Lin, H.Z.3
  • 39
    • 2642638793 scopus 로고    scopus 로고
    • Tumor necrosis factor promoter polymorphism at position-238 is associated with chronic active hepatitis C infection
    • Hohler T, Kruger A, Gerken G, Schneider PM, Meyer zum Buscenfelde KH, Rittner C. Tumor necrosis factor promoter polymorphism at position-238 is associated with chronic active hepatitis C infection. J Med Virol 1998; 54: 173-177.
    • (1998) J Med Virol , vol.54 , pp. 173-177
    • Hohler, T.1    Kruger, A.2    Gerken, G.3    Schneider, P.M.4    Meyer Zum Buscenfelde, K.H.5    Rittner, C.6
  • 40
    • 0032862558 scopus 로고    scopus 로고
    • Frequency and nature of cytokine gene polymorphism in type 1 autoimmune hepatitis
    • Cookson S, Constantini PK, Clare M et al. Frequency and nature of cytokine gene polymorphism in type 1 autoimmune hepatitis. Hepatology 1999; 30: 851-856.
    • (1999) Hepatology , vol.30 , pp. 851-856
    • Cookson, S.1    Constantini, P.K.2    Clare, M.3
  • 41
    • 0024503589 scopus 로고
    • Prolonged activation of jun and collagenase genes by tumor necrosis factor-alpha
    • Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M. Prolonged activation of jun and collagenase genes by tumor necrosis factor-alpha. Nature 1989; 337: 661-663.
    • (1989) Nature , vol.337 , pp. 661-663
    • Brenner, D.A.1    O'Hara, M.2    Angel, P.3    Chojkier, M.4    Karin, M.5
  • 42
    • 0036294003 scopus 로고    scopus 로고
    • Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C
    • Hickman IJ, Clouston AD, Macdonald GA et al. Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C. Gut 2002; 51: 89-94.
    • (2002) Gut , vol.51 , pp. 89-94
    • Hickman, I.J.1    Clouston, A.D.2    Macdonald, G.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.