Regulation of serum-induced fibronectin expression by protein kinases, cytoskeletal integrity, and CREB

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 282, Issue 2 26-2, 2002, Pages

  Michaelson, Jeffrey E ^a   Ritzenthaler, Jeffrey D ^a   Roman, Jesse ^a  

^a ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Actin microfilaments; Cyclic adenosine 5 monophosphate response element binding protein; Gene transcription; Microtubules; Murine fibroblasts

Indexed keywords

COLLAGEN TYPE 1; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FIBRIN; FIBRONECTIN; GLYCOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; PROTEIN KINASE C INHIBITOR;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CONTROLLED STUDY; CYTOSKELETON; DNA BINDING; ENZYME ASSAY; EXTRACELLULAR MATRIX; GENE DISRUPTION; GENETIC TRANSCRIPTION; HUMAN; INFLAMMATION; INTERSTITIUM; LUNG INJURY; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; WOUND HEALING;

EID: 0036086990     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00445.2000     Document Type: Article

References (74)

1. Cytochalasin D stimulation of tyrosine phosphorylation and phosphotyrosine-associated kinase activity in vascular smooth muscle cells
2. Fibronectin inhibits the terminal differentiation of human keratinocytes
3. Analysis of fibronectin receptor function with monoclonal antibodies: Roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization
4. PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo
5. Expression of fibronectin and interstitial collagen genes in smooth muscle cells: Modulation by low molecular weight heparin fragments and serum
6. High lung inflation increases mRNA levels of ECM components and growth factors in lung parenchyma
7. Pathogenesis of fibrosis in acute lung injury
8. Fibroproliferative disorders
9. Role of fibronectin as a growth factor for fibroblasts
10. Role of fibronectin in fibrotic lung disease. A growth factor for human lung fibroblasts
11. Disruption of cytoskeletal structures results in the induction of the urokinase-type plasminogen activator gene expression
12. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
13. Transforming growth factor β 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis
14. Alveolitis and collapse in the pathogenesis of pulmonary fibrosis
15. Integrins and signal transduction: The road taken
16. Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization
17. Fibronectin promotes proliferation of naive and memory T cells by signaling through both the VLA-4 and VLA- 5 integrin molecules
18. Expression of the fibronectin gene
19. Glycoprotein synthesis and secretion. Expression of fibronectin and its cell surface receptors
20. Cloning and analysis of the promoter region of the human fibronectin gene
21. Serum stimulation of fibronectin gene expression appears to result from rapid serum-induced binding of nuclear proteins to a cAMP response element
22. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
23. Ventilator-induced lung injury
24. Attachment, spreading, and locomotion of avian neural crest cells are mediated by multiple adhesion sites on fibronectin molecules
25. Growth factors and mitogen activated protein kinases
26. The adult respiratory distress syndrome: Cell populations and soluble mediators in the air spaces of patients at high risk
27. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
28. Integrin signaling
29. Fibronectin modulates expression of interleukin-1β and its receptor antagonist in human mononuclear cells
30. Integrins: Versatility, modulation, and signaling in cell adhesion
31. Integrins as mechanochemical transducers
32. The cytoskeleton and cell signaling: Component localization and mechanical coupling
33. Colchicine and cytochalasin B enhance cAMP accumulation via post receptor actions
34. Signal transduction from the extracellular matrix
35. Cytokines of the lung
36. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
37. An immunohistochemical study of architectural remodeling and connective tissue synthesis in pulmonary fibrosis
38. Stimulation of fibronectin synthesis through protein kinase C signaling pathway in normal and transformed human lung fibroblasts
39. Antagonistic regulation of protein kinase C-induced stimulation of fibronectin synthesis by cyclic AMP in human lung fibroblasts
40. Cytoskeletal reorganization and TPA differently modify AP-1 to induce the urokinase-type plasminogen activator gene in LLC-PK 1 cells
41. Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK)
42. Fibronectin: A versatile matrix protein with roles in thoracic development, repair, and infection
43. Disruption of microtubule network in human monocytes induces expression of interleukin-1 but not that of interleukin-6 nor tumor necrosis factor-α
44. Plasma fibronectin and fibrin formation
45. Extracellular matrix assembly
46. 5 subunit cytoplasmic domain and protein kinase C
47. A fibronectin matrix is required for differentiation of murine erythroleukemia cells into reticulocytes
48. Cytoskeletal active drugs modulate signal transduction in the protein kinase C pathway
49. Transcriptional regulation of the interleukin-1β promoter via fibrinogen engagement of the CD18 integrin receptor
50. Fibrin matrices enhance the expression of interleukin-1β by human peripheral blood mononuclear cells, Implications for lung granulomatous inflammation
51. Migration of bronchial epithelial cells to extracellular matrix components
52. Differential effects of protein kinase C inhibitors on fibronectin-induced interleukin-1β gene transcription, protein synthesis and secretion in human monocytic cells
53. Transforming growth factor β stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts
54. Extracellular matrices and lung inflammation
55. Extracellular matrices in the pathogenesis of lung injury and repair
56. Distribution of extracellular matrices, matrix receptors, and transforming growth factor β 1 in human and experimental lung granulomatous inflammation
57. The fibronectin receptor is organized by extracellular matrix fibronectin: Implications for oncogenic transformation and for cell recognition of fibronectin matrices
58. Fibronectins and fibronectin receptors in lung development, injury and repair
59. Differential modes of regulation of interleukin-1β expression by extracellular matrices
60. Cytoskeletal control of gene expression: Depolymerization of microtubule activates NF-kB
61. Molecular mechanism of colchicine action: Induced local unfolding of β-tubulin
62. Disruption of microtubules inhibits the stimulation of tissue plasminogen activator expression and promotes plasminogen activator inhibitor type I expression in human endothelial cells
63. Microtubule integrity regulates src-like and extracellular signal-regulated kinase activities in human pro-monocytic cells. Importance for interleukin-1 production
64. Adherence-dependent increase in human monocyte PDGF(B) mRNA is associated with increases in c-fos, c-jun, and EGR 2 mRNA
65. Tissue fibrin deposition during acute lung injury in rabbits and its relationship to local expression of procoagulant and fibrinolytic activities
66. Taxol selectively blocks microtubule dependent NF-κB activation by phorbol ester via inhibition of IκBα phosphorylation and degradation
67. Acute lung injury: The role of cytokines in the elicitation of neutrophils
68. Signal transduction of mechanical stimuli is dependent on microfilament integrity: Identification of osteopontin as a mechanically induced gene in osteoblasts
69. Mechanotransduction across the cell surface and through the cytoskeleton
70. Antagonism by taxol of effects of microtubule-disrupting agents on lymphocyte cAMP metabolism and cell function
71. 1 integrin in cell motility and fibronectin matrix assembly
72. Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix
73. Coupling of the RAS-MAPK pathways to gene activation by RSK2, a growth factor-regulated CREB kinase
74. Embryonic mesodermal defects in α 5 deficient mice