Differentiation of polymorphonuclear neutrophils in patients with systemic infections and chronic inflammatory diseases: Evidence of prolonged life span and de novo synthesis of fibronectin

Journal of Molecular Medicine

Volumn 78, Issue 6, 2000, Pages 337-345

  Wagner, Christof ^a   Pioch, Marco ^a   Meyer, Christiane ^a   Iking Konert, Christof ^a   Andrassy, Konrad ^a   Hänsch, G Maria ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

CD64; Elastase; Fibronectin; Inflammatory disease; Polymorphonuclear neutrophils

Indexed keywords

CD64 ANTIGEN; ELASTASE; FIBRONECTIN; IMMUNOGLOBULIN RECEPTOR; INTEGRIN RECEPTOR; MESSENGER RNA;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL ADHESION; CELL CYCLE; CELL DIFFERENTIATION; CELL SURVIVAL; CHRONIC INFLAMMATION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INFECTION; NEUTROPHIL; PROTEIN DOMAIN; PROTEIN POLYMORPHISM; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

EID: 0033857526     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090000107     Document Type: Article

References (39)

1. Effects of gamma interferon on human neutrophils: Protection from deterioation on storage
2. Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators
3. Apoptosis in resolution of inflammation
4. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products
5. Induction of MHC class II on human polymorphonuclear neutrophils by granulocyte/macrophage colony-stimulating factor, IFN-gamma, and IL-3
6. Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression
7. Inhibition of apoptosis in polymorphonuclear neutrophils from burn patients
8. Interleukin-6 delays neutrophil apoptosis
9. Interleukin 10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis
10. Cytokines regulate membrane-bound leukocyte elastase on neutrophils: A novel mechnanism for effector activity
11. Integrins: Versatility, modulation, and signaling in cell adhesion
12. Multiple sites of alternative splicing of the rat fibronectin gene transcript
13. Primary structure of human fibronectin: Differential splicing may generate at least 10 polypeptides from a single gene
14. Regulation of alternative splicing in the IIICS region of human fibronectin pre-mRNA encoding cell binding sites CS1 and CS5
15. Lymphoid cells recognize an alternative splicing segment of fibronectin via the integrin receptor alpha4 beta1
16. Nomenclature of systemic vasculitis: The proposal of an international consensus conference
17. Quantitative single cell analysis
18. Autoantibodies to polymorphonuclear neutrophils (PMN) elastase are not inhibitory, but enhance elastase activity
19. Fibronectin synthesis by tubular epithelial cells in culture: Effects of PDGF and TGF-β on synthesis and splicing
20. Expression of the 14 kDa galactose-binding protein, galectin-1, on human tubular epithelial cells
21. The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues
22. Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the molecule
23. New perspectives in cell adhesion. RGD and integrin
24. Endogenous fibronectin of blood polymorphonuclear leukocytes: Immunological characterization and subcellular localization
25. Endogenous fibronectin of blood polymorphonuclear leukocytes: Stimulus-induced secretion and proteolysis by cell surface-bound elastase
26. Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat
27. A tumor-associated fibronectin isoform generated by alternative splicing of messenger RNA precursors
28. The alternative splicing of fibronectin pre-mRNA is altered during aging and response to growth factors
29. Fibronectin synthesis by activated T lymphocytes: Upregulation of a surface-associated isoform with signalling function
30. Extracellular proteolysis of fibronectin by neutrophils: Characterization and the effects of recombinant cytokines
31. Fibronectin fragments, but not intact fibronectin, signalling through the fibronectin receptor induce metalloproteinase gene expression in fibroblasts
32. Cryptic chemotactic activity of fibronectin for human monocytes resides in the 120 kDa fibroblastic cell-binding fragment
33. Neutrophil chemotaxis in response to TGFβ isoforms (TGFβ1, TGFβ2,TGβ3) is mediated by fibronectin
34. Expression of elastase to the surface of human polymorphonuclear neutrophils: The complement receptor type 3 (CR3, CD11b/CD18) serves as ligand
35. Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex
36. VLA-4 mediates CD3-dependent CD4+ T-cell activation via the CS1 alternatively spliced domain of fibronectin
37. Fibronectin gene expression in polymorphonuclear leukocytes. Accumulation of mRNA in inflammatory cells
38. Protein biosynthetic activity of polymorphonuclear leukocytes in inflammatory arthopathies. Increased synthesis and release of fibronectin