Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 5, 1997, Pages 511-522

  Lee, Caroline G L ^a   Jeang, Kuan Teh ^b   Martin, Malcolm A ^b   Pastan, Ira ^a   Gottesman, Michael M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; GLYCOPROTEIN P; RIBOZYME; VINCRISTINE; VIRUS RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENCEPHALOMYOCARDITIS VIRUS; FLUORESCENCE ACTIVATED CELL SORTER; GENE CONSTRUCT; GENE EXPRESSION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; MARKER GENE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOSOME; T LYMPHOCYTE;

ANIMALIA; ENCEPHALOMYOCARDITIS VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030830598     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.511     Document Type: Article

References (5)

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2. ARAN, J.M., GERMANN, U.A., GOTTESMAN, M.M., and PASTAN, I. (1996a). Construction and characterization of a selectable multidrug resistance glucocerebrosidase fusion gene. Cytokines Mol. Ther. 2, 47-57.
3. ARAN, J.M., GOTTESMAN, M.M., and PASTAN, I. (1994). Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector. Proc. Natl. Acad. Sci. USA 91, 3176-3180.
4. ARAN, J.M., LICHT, T., GOTTESMAN, M.M., and PASTAN, I. (1996b). Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using bicistronic MDR retrovirus and a new selection strategy. Human Gene Ther. 7, 2165-2175.
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