Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: Relevance to therapeutical application for Parkinson's disease

Journal of Neuroscience Research

Volumn 63, Issue 5, 2001, Pages 402-409

  Shimoke, Koji ^a   Chiba, Hiroaki ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Apoptosis; Cell survival; Parkinson's disease; ROS; Signal transduction

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; TYROSINE KINASE RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CELL SURVIVAL; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL; NONHUMAN; PARKINSON DISEASE; PARKINSONISM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID CHLOROMETHYL KETONES; AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CHROMONES; COUMARINS; CYSTEINE PROTEINASE INHIBITORS; DOPAMINE AGENTS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FLAVONOIDS; GENES, DOMINANT; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; MUTAGENESIS, SITE-DIRECTED; NEOPLASM PROTEINS; NERVE GROWTH FACTOR; OLIGOPEPTIDES; PARKINSON DISEASE; PARKINSONIAN DISORDERS; PC12 CELLS; PHOSPHOSERINE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0035283083     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20010301)63:5<402::AID-JNR1035>3.0.CO;2-F     Document Type: Article

References (42)

1. 3-thymidine incorporation assay
2. Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8-hydroxyguanine levels in substantia nigra
3. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
4. Regulation of cell death protease caspase-9 by phosphorylation
5. Free radicals and MPTP-induced selective destruction of substantia nigra compacta neurons
6. +-induced dopaminergic neuronal cell death: Role of caspases, ROS, and JNK
7. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor dependent sympathetic neurons
8. Akt phosphorylation of BAD couples survival signals to the cellintrinsic death machinery
9. Neuronal antioxidant system and MPTP-induced oxidative stress in the striatum and in brainstem of the rat
10. Role of oxidative stress in the manganese and 1-methyl-4-(2′ethylphenyl)-1,2,3.6-tetrahydropyridine-induced apoptosis in PC12 cells
11. Apoptosis and DNA degradation by 1-methyl-4-phenylpyridinium in neurons
12. Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons
13. Regulation of neuronal survival by the serine-threonine protein kinase Akt
14. A caspase-activated Dnase that degradates DNA during apoptosis, and its inhibitor ICAD
15. The surgical treatment of Parkinson's disease
16. Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: Relevance to Parkinson's disease
17. Neurotrophic factor therapy for nervous system degenerative disease
18. +) in the pathogenesis of Parkinson's disease
19. Oxidative damage in neurodegenerative disease
20. A functional role for death proteases in s-Myc- and c-Myc-mediated apoptosis
21. Presenilin-1 mutations downregulate the signaling pathway of the unfolded protein response
22. Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
23. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
24. Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells
25. Gene transfer to the brain: Emerging therapeutic strategy in psychiatry
26. NGF in experimental models of Parkinson disease
27. Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3.6-tetrahydropyridine (MPTP) to mice on interleukin-1β and nerve growth factor in the striatum
28. Cell death during development of the nervous system
29. A new fluorometric assay for cytotoxicity measurements in vitro
30. Role of glycogen synthese kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway
31. Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient
32. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
33. NF-κB is a target of Akt in anti-apoptotic PDGF signalling
34. New roles for Src kinases in control of cell survival and angiogenesis
35. +-induced apoptosis of cerebellar granule neurons
36. Synthetic lipid products of P13-kinase which are added to culture medium prevent lowK(+)-induced apoptosis of cerebellar granure neurons via Akt kinase activation
37. WAF1/Cip1
38. Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity
39. Effect of MPTP and L-deprenyl on antioxidant enzymes and lipid peroxidation levels in mouse brain
40. The PI3K-PDK1 connection: More than just a road to PKB
41. Inhibition of p42 and p44 mitogen-activated protein kinase activity by PD98059 does not suppress nerve growth factor-induced survival of sympathetic neurons
42. Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway