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Volumn 1, Issue 4, 2004, Pages 417-423

Targeting the cell cycle

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; ATM PROTEIN; ATR PROTEIN; CARBAZOLE DERIVATIVE; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLIN D; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; DNA; DNA BINDING PROTEIN; FLAVOPIRIDOL; INDISULAM; ISPINESIB; KINESIN; METHYLXANTHINE DERIVATIVE; N [5 (5 TERT BUTYL 2 OXAZOLYLMETHYLTHIO) 2 THIAZOLYL]ISONIPECOTAMIDE; PENTOXIFYLLINE; POLO LIKE KINASE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; RETINOBLASTOMA PROTEIN; ROSCOVITINE; SB 218078; TRANSCRIPTION FACTOR E2F; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 13344269594     PISSN: 17406773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddstr.2004.11.014     Document Type: Review
Times cited : (2)

References (40)
  • 1
    • 0037075887 scopus 로고    scopus 로고
    • Cyclin D-dependent kinases, INK4 inhibitors and cancer
    • S. Ortega et al. Cyclin D-dependent kinases, INK4 inhibitors and cancer Biochim. Biophys. Acta 1602 2002 73-87
    • (2002) Biochim. Biophys. Acta , vol.1602 , pp. 73-87
    • Ortega, S.1
  • 2
    • 0742324404 scopus 로고    scopus 로고
    • Life and death decisions by E2F-1
    • L.A. Bell K.M. Ryan Life and death decisions by E2F-1 Cell Death Differ. 11 2004 137-142
    • (2004) Cell Death Differ. , vol.11 , pp. 137-142
    • Bell, L.A.1    Ryan, K.M.2
  • 3
    • 1542541543 scopus 로고    scopus 로고
    • E2F1 as a target: Promoter-driven suicide and small molecule modulators
    • W.G. Kaelin Jr E2F1 as a target: Promoter-driven suicide and small molecule modulators Cancer Biol. Ther. 2 4 Suppl. 1 2003 34-40
    • (2003) Cancer Biol. Ther. , vol.2 , Issue.4 SUPPL. 1 , pp. 34-40
    • Kaelin Jr., W.G.1
  • 4
    • 2342591929 scopus 로고    scopus 로고
    • Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents
    • Y. Dai S. Grant Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents Curr. Oncol. Rep. 6 2004 123-130
    • (2004) Curr. Oncol. Rep. , vol.6 , pp. 123-130
    • Dai, Y.1    Grant, S.2
  • 5
    • 13244255220 scopus 로고    scopus 로고
    • The use of CDK inhibitors in oncology: A pharmaceutical perspective
    • P.M. Fischer The use of CDK inhibitors in oncology: A pharmaceutical perspective Cell Cycle 3 2004 742-746
    • (2004) Cell Cycle , vol.3 , pp. 742-746
    • Fischer, P.M.1
  • 6
    • 13344286390 scopus 로고    scopus 로고
    • Inhibition of Cdk4 causes tumor regression
    • J. Booth et al. Inhibition of Cdk4 causes tumor regression Proc. Am. Assoc. Cancer Res. 45 2004 191
    • (2004) Proc. Am. Assoc. Cancer Res. , vol.45 , pp. 191
    • Booth, J.1
  • 7
    • 0033406451 scopus 로고    scopus 로고
    • Sensitization of cancer cells to DNA damage-induced cell death by specific cell cycle G2 checkpoint abrogation
    • M. Suganuma et al. Sensitization of cancer cells to DNA damage-induced cell death by specific cell cycle G2 checkpoint abrogation Cancer Res. 59 1999 5887-5891
    • (1999) Cancer Res. , vol.59 , pp. 5887-5891
    • Suganuma, M.1
  • 8
    • 1542754615 scopus 로고    scopus 로고
    • Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint
    • Z. Chen et al. Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint Mol. Cancer Ther. 2 2003 543-548
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 543-548
    • Chen, Z.1
  • 9
    • 4444344407 scopus 로고    scopus 로고
    • G2 checkpoint abrogators as anticancer drugs
    • T. Kawabe G2 checkpoint abrogators as anticancer drugs Mol. Cancer Ther. 3 2004 513-519
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 513-519
    • Kawabe, T.1
  • 10
    • 1542725073 scopus 로고    scopus 로고
    • Targeting the checkpoint kinases: Chemosensitization versus chemoprotection
    • B-B.S. Zhou J. Bartek Targeting the checkpoint kinases: chemosensitization versus chemoprotection Nat. Rev. Cancer 4 2004 216-225
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 216-225
    • Zhou, B-B.S.1    Bartek, J.2
  • 11
    • 0242386588 scopus 로고    scopus 로고
    • Natural, semisynthetic and synthetic microtubule inhibitors for cancer therapy
    • T. Beckers S. Mahboobi Natural, semisynthetic and synthetic microtubule inhibitors for cancer therapy Drugs Future 28 2003 767-785
    • (2003) Drugs Future , vol.28 , pp. 767-785
    • Beckers, T.1    Mahboobi, S.2
  • 12
    • 0033615357 scopus 로고    scopus 로고
    • Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
    • T.U. Mayer et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen Science 286 1999 971-974
    • (1999) Science , vol.286 , pp. 971-974
    • Mayer, T.U.1
  • 13
    • 10744220712 scopus 로고    scopus 로고
    • Inhibition of a mitotic motor protein: Where, how, and conformational consequences
    • Y. Yan et al. Inhibition of a mitotic motor protein: Where, how, and conformational consequences J. Mol. Biol. 335 2004 547-554
    • (2004) J. Mol. Biol. , vol.335 , pp. 547-554
    • Yan, Y.1
  • 14
    • 2942615282 scopus 로고    scopus 로고
    • Polo-like kinases and the orchestration of cell division
    • F.A. Barr et al. Polo-like kinases and the orchestration of cell division Nat. Rev. Mol. Cell. Biol. 5 2004 429-441
    • (2004) Nat. Rev. Mol. Cell. Biol. , vol.5 , pp. 429-441
    • Barr, F.A.1
  • 15
    • 2942597981 scopus 로고    scopus 로고
    • The design of drug candidate molecules as selective inhibitors of therapeutically relevant kinases
    • P.M. Fischer The design of drug candidate molecules as selective inhibitors of therapeutically relevant kinases Curr. Med. Chem. 11 2004 1563-1583
    • (2004) Curr. Med. Chem. , vol.11 , pp. 1563-1583
    • Fischer, P.M.1
  • 16
    • 1642575356 scopus 로고    scopus 로고
    • In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176
    • M. Takagi et al. In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176 Investig. New Drugs 21 2003 387-399
    • (2003) Investig. New Drugs , vol.21 , pp. 387-399
    • Takagi, M.1
  • 17
    • 0042093747 scopus 로고    scopus 로고
    • Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human
    • A. Ewart-Toland et al. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human Nat. Genet. 34 2003 403-412
    • (2003) Nat. Genet. , vol.34 , pp. 403-412
    • Ewart-Toland, A.1
  • 18
    • 4444239881 scopus 로고    scopus 로고
    • The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer
    • S. Rojanala et al. The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer Mol. Cancer Ther. 3 2004 451-457
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 451-457
    • Rojanala, S.1
  • 19
    • 1542543989 scopus 로고    scopus 로고
    • Targeting Aurora-2 kinase in cancer
    • S.L. Warner et al. Targeting Aurora-2 kinase in cancer Mol. Cancer Ther. 2 2003 589-595
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 589-595
    • Warner, S.L.1
  • 20
    • 0038746733 scopus 로고    scopus 로고
    • The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
    • S. Hauf et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint J. Cell Biol. 161 2003 281-294
    • (2003) J. Cell Biol. , vol.161 , pp. 281-294
    • Hauf, S.1
  • 21
    • 0036490442 scopus 로고    scopus 로고
    • Smart drugs: Tyrosine kinase inhibitors in cancer therapy
    • L.K. Shawver et al. Smart drugs: Tyrosine kinase inhibitors in cancer therapy Cancer Cell 1 2002 117-123
    • (2002) Cancer Cell , vol.1 , pp. 117-123
    • Shawver, L.K.1
  • 22
    • 0038685911 scopus 로고    scopus 로고
    • CDK inhibitors in clinical development for the treatment of cancer
    • P.M. Fischer A. Gianella-Borradori CDK inhibitors in clinical development for the treatment of cancer Exp. Opin. Investig. Drugs 12 2003 955-970
    • (2003) Exp. Opin. Investig. Drugs , vol.12 , pp. 955-970
    • Fischer, P.M.1    Gianella-Borradori, A.2
  • 23
    • 0035235736 scopus 로고    scopus 로고
    • Mitotic kinases as regulators of cell division and its checkpoints
    • E.A. Nigg Mitotic kinases as regulators of cell division and its checkpoints Nat. Rev. Mol. Cell. Biol. 2 2001 21-32
    • (2001) Nat. Rev. Mol. Cell. Biol. , vol.2 , pp. 21-32
    • Nigg, E.A.1
  • 24
    • 0347917093 scopus 로고    scopus 로고
    • Cell-cycle targeted therapies
    • C. Swanton Cell-cycle targeted therapies Lancet Oncol. 5 2004 27-36
    • (2004) Lancet Oncol. , vol.5 , pp. 27-36
    • Swanton, C.1
  • 25
    • 13344278079 scopus 로고    scopus 로고
    • Identification of pharmacodynamic biomarkers for CYC202 (R-roscovitine), a cyclin dependent kinase inhibitor
    • S.R. Green et al. Identification of pharmacodynamic biomarkers for CYC202 (R-roscovitine), a cyclin dependent kinase inhibitor Proc. Am. Assoc. Cancer Res. 45 2004 846
    • (2004) Proc. Am. Assoc. Cancer Res. , vol.45 , pp. 846
    • Green, S.R.1
  • 26
    • 13244292822 scopus 로고    scopus 로고
    • A phase I trial of the oral cyclin dependent kinase inhibitor CYC202 in patients with advanced malignancy
    • J.D. White et al. A phase I trial of the oral cyclin dependent kinase inhibitor CYC202 in patients with advanced malignancy Proc. Am. Soc. Clin. Oncol. 23 2004 205
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 205
    • White, J.D.1
  • 27
    • 3042536038 scopus 로고    scopus 로고
    • Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol
    • G.I. Shapiro Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol Clin. Cancer Res. 10 2004 4270s-4275s
    • (2004) Clin. Cancer Res. , vol.10
    • Shapiro, G.I.1
  • 28
    • 1642405155 scopus 로고    scopus 로고
    • A phase I study to determine the safety and pharmacokinetics (PK) of BMS-387032 given intravenously every three weeks in patients with metastatic refractory solid tumors
    • (Abstract 798)
    • S.F. Jones et al. A phase I study to determine the safety and pharmacokinetics (PK) of BMS-387032 given intravenously every three weeks in patients with metastatic refractory solid tumors Proc. Am. Soc. Clin. Oncol. 22 2003 199 (Abstract 798)
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 199
    • Jones, S.F.1
  • 29
    • 12144285797 scopus 로고    scopus 로고
    • N-(Cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5- [5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazol yl]-4-piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent
    • R.N. Misra et al. N-(Cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5- [5-(1,1-Dimethylethyl)-2-oxazolyl]methy l]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent J. Med. Chem. 47 2004 1719-1728
    • (2004) J. Med. Chem. , vol.47 , pp. 1719-1728
    • Misra, R.N.1
  • 30
    • 3543142779 scopus 로고    scopus 로고
    • Novel approaches in oncology at AstraZeneca
    • C. Wheeler et al. Novel approaches in oncology at AstraZeneca EJC Suppl. 1 2003 3-8
    • (2003) EJC Suppl. , vol.1 , pp. 3-8
    • Wheeler, C.1
  • 31
    • 13344275252 scopus 로고    scopus 로고
    • Phase I trial of novel kinesin spindle protein (KSP) inhibitor SB-715992 IV days 1, 8, 15 q 28 days
    • H.A. Burris et al. Phase I trial of novel kinesin spindle protein (KSP) inhibitor SB-715992 IV days 1, 8, 15 q 28 days Proc. Am. Soc. Clin. Oncol. 23 2004 128
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 128
    • Burris, H.A.1
  • 32
    • 0037046495 scopus 로고    scopus 로고
    • Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells
    • B. Spankuch-Schmitt et al. Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells Oncogene 21 2002 3162-3171
    • (2002) Oncogene , vol.21 , pp. 3162-3171
    • Spankuch-Schmitt, B.1
  • 33
    • 68049085247 scopus 로고    scopus 로고
    • A Phase I and pharmacokinetic study of HMN-214, a novel oral polo-like kinase inhibitor, in patients with advanced solid tumors
    • D.D. Von Hoff et al. A Phase I and pharmacokinetic study of HMN-214, a novel oral polo-like kinase inhibitor, in patients with advanced solid tumors Proc. Am. Soc. Clin. Oncol. 23 2004 203
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 203
    • Von Hoff, D.D.1
  • 34
    • 2342593974 scopus 로고    scopus 로고
    • Aurora kinases dawn as cancer drug targets
    • E.A. Sausville Aurora kinases dawn as cancer drug targets Nat. Med. 10 2004 234-235
    • (2004) Nat. Med. , vol.10 , pp. 234-235
    • Sausville, E.A.1
  • 35
    • 2342639645 scopus 로고    scopus 로고
    • VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
    • E.A. Harrington et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo Nat. Med. 10 2004 262-267
    • (2004) Nat. Med. , vol.10 , pp. 262-267
    • Harrington, E.A.1
  • 36
    • 13344275253 scopus 로고    scopus 로고
    • Aurora kinase inhibitors
    • Presented at: Gordon Research Conference: Molecular Therapeutics of Cancer, 18-23 July 2004, Colby-Sawyer College, New London, NH, USA
    • Hitoshi, Y. (2004) Aurora kinase inhibitors. Presented at: Gordon Research Conference: Molecular Therapeutics of Cancer, 18-23 July 2004, Colby-Sawyer College, New London, NH, USA (http://www.rigel.com/rigel/oncology_poster)
    • (2004)
    • Hitoshi, Y.1
  • 37
    • 13344286391 scopus 로고    scopus 로고
    • Development of a new series of thiazolo-quinazoline inhibitors targeting Aurora kinase
    • A.A. Mortlock Development of a new series of thiazolo-quinazoline inhibitors targeting Aurora kinase Proc. Am. Assoc. Cancer Res. 45 2004 574
    • (2004) Proc. Am. Assoc. Cancer Res. , vol.45 , pp. 574
    • Mortlock, A.A.1
  • 38
    • 2142792056 scopus 로고    scopus 로고
    • A phase II study of E7070 in patients with metastatic, recurrent, or refractory head and neck squamous cell carcinoma (HNSCC): Clinical activity and post-treatment modulation of Rb phosphorylation
    • (Abstract 800)
    • R.I. Haddad et al. A phase II study of E7070 in patients with metastatic, recurrent, or refractory head and neck squamous cell carcinoma (HNSCC): Clinical activity and post-treatment modulation of Rb phosphorylation Proc. Am. Soc. Clin. Oncol. 22 2003 200 (Abstract 800)
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 200
    • Haddad, R.I.1
  • 39
    • 0037315480 scopus 로고    scopus 로고
    • Indisulam: An anticancer sulfonamide in clinical development
    • C.T. Supuran Indisulam: An anticancer sulfonamide in clinical development Exp. Opin. Investig. Drugs 12 2003 283-287
    • (2003) Exp. Opin. Investig. Drugs , vol.12 , pp. 283-287
    • Supuran, C.T.1
  • 40
    • 3042851771 scopus 로고    scopus 로고
    • A phase I clinical and pharmacokinetic study of Ro 31-7453 given as a 7- or 14-day oral twice daily schedule every 4 weeks in patients with solid tumors
    • R. Salazar et al. A phase I clinical and pharmacokinetic study of Ro 31-7453 given as a 7- or 14-day oral twice daily schedule every 4 weeks in patients with solid tumors Clin. Cancer Res. 10 2004 4374-4382
    • (2004) Clin. Cancer Res. , vol.10 , pp. 4374-4382
    • Salazar, R.1


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