Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3,4- tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N- methyltransferase versus the α2-adrenoceptor

Journal of Medicinal Chemistry

Volumn 42, Issue 18, 1999, Pages 3588-3601

  Grunewald, Gary L ^a   Caldwell, Timothy M ^a   Li, Qifang ^a   Slavica, Men ^a   Criscione, Kevin R ^a   Borchardt, Ronald T ^a   Wang, Wen ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 FLUOROMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 4,9 DIHYDRO 7 METHOXY 3H PYRIDO[3,4 B]INDOLE; 7,8 DICHLORO 1,2,3,4 TETRAHYDROISOQUINOLINE; 8,9 DICHLORO 2,3,4,5 TETRAHYDRO 1H 2 BENZAZEPINE; ALPHA 2 ADRENERGIC RECEPTOR; ISOQUINOLINE DERIVATIVE; PHENYLETHANOLAMINE N METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; BLOOD PRESSURE REGULATION; CATALYSIS; CATECHOLAMINE RELEASE; DRUG SYNTHESIS; GENE TARGETING; HORMONE RELEASE; HYPERTENSION; NERVE DEGENERATION; PROTEIN LOCALIZATION; RECEPTOR AFFINITY;

ADRENAL GLANDS; ANIMALS; BINDING, COMPETITIVE; BLOOD-BRAIN BARRIER; CATTLE; CLONIDINE; ENZYME INHIBITORS; FLUORINE COMPOUNDS; ISOQUINOLINES; MODELS, MOLECULAR; PERMEABILITY; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 0033539037     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990045e     Document Type: Article

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