Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the α2-adrenoceptor: The development of new, highly selective inhibitors of PNMT

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 3, 1999, Pages 481-486

  Grunewald, Gary L ^a   Caldwell, Timothy M ^a   Dahanukar, Vilas H ^a   Jalluri, Ravi K ^a   Criscione, Kevin R ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Antihypertension; Enzyme inhibitor; Molecular modelling mechanics; Receptors

Indexed keywords

1,2,3,4 TETRAHYDRO 7 ISOQUINOLINESULFONAMIDE; 3 TRIFLUOROMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE DERIVATIVE; 7,8 DICHLORO 1,2,3,4 TETRAHYDROISOQUINOLINE; ALPHA 2 ADRENERGIC RECEPTOR; ENZYME INHIBITOR; PHENYLETHANOLAMINE; PHENYLETHANOLAMINE N METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; HYDROPHILICITY; MOLECULAR MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; MODELS, CHEMICAL; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; RECEPTORS, ADRENERGIC, ALPHA-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033535114     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00022-0     Document Type: Article

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