Moderate alcohol consumption induces sustained cardiac protection by activating PKC-ε and Akt

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 283, Issue 1 52-1, 2002, Pages

  Zhou, Hui Zhong ^a   Karliner, Joel S ^a   Gray, Mary O ^a  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

Author keywords

Ethanol; Heart; Ischemia; Reperfusion; Signaling

Indexed keywords

ALCOHOL; CREATINE KINASE; PROTEIN KINASE B; PROTEIN KINASE C;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEMODYNAMICS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0036302685     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00408.2001     Document Type: Article

References (47)

1. Banbury Conference on Genetic Background in Mice. Mutant mice and neuroscience: Recommendations concerning genetic background
2. ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
3. Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and εPKC
4. Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice
5. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
6. 1-adrenergic receptor subtypes activate different PKC isoforms in mouse heart
7. Sustained in vivo cardiac protection by a rationally designed peptide that causes ε protein kinase C translocation
8. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart
9. Light-to-moderate alcohol consumption and mortality in the Physicians' Health Study enrollment cohort
10. Gene targeting studies of mammalian behavior: Is it the mutation or the background genotype?
11. A technique for accurate measurement of degrees of alcohol intoxication in small animals
12. Quantitative studies on alcohol tolerance in man
13. A selective ε-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death
14. Novel delivery of a peptide agonist of ε protein kinase C induces acute protection against reperfusion injury in mouse heart
15. Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart
16. Supersensitivity to allosteric GABAA receptor modulators and alcohol in mice lacking PKCε
17. A novel nociceptor signaling pathway revealed in protein kinase C ε mutant mice
18. Medical and cellular implications of stunning, hibernation, and preconditioning. An NHLBI workshop
19. Phorbol esters increase the amount of phospholipid-dependent protein kinase associated with plasma membrane
20. Acute ethanol exposure fails to elicit preconditioning-like protection in in situ rabbit hearts because of its continued presence during ischemia
21. Dual regulation of platelet protein kinase B
22. Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C
23. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
24. Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the ε isozyme of protein kinase C
25. Alcohol consumption reduces ischemia-reperfusion injury by species-specific signaling in guinea pigs and rats
26. Regular alcohol consumption mimics cardiac preconditioning by protecting against ischemia-reperfusion injury
27. Activation of ε protein kinase C correlates with a cardioprotective effect of regular ethanol consumption
28. Cardiotrophic effects of protein kinase C epsilon: Analysis by in vivo modulation of PKC epsilon translocation
29. Prior alcohol consumption and mortality following myocardial infarction
30. Reduced operant ethanol self-administration and in vivo mesolimbic dopamine response to ethanol in PKCε-deficient mice
31. ATP channels mediate the beneficial effects of chronic ethanol ingestion
32. Mammalian TOR controls one of the two kinase pathways acting upon nPKCδ and nPKCε
33. Multiple pathways control protein kinase C phosphorylation
34. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in rabbits
35. Functional proteomic analysis of protein kinase C ε complexes in normal heart and during cardioprotection
36. Akt/protein kinase B upregulates Bcl-2 expression through cAMP-response element-binding protein
37. Protein kinase C isoform expression and activity in the mouse heart
38. Role of protein kinase C as a mediator of ischemic preconditioning: A critical review
39. Peptide modulators of protein-protein interactions in intracellular signaling
40. Alcohol consumption and mortality among middle-aged and elderly U.S. adults
41. Cellular signaling: Pivoting around PDK-1
42. Preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C
43. Use of functional proteomics to investigate PKCε-mediated cardioprotection: The signaling module hypothesis
44. Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1
45. The preconditioning phenomenon. A tool for the scientist or a clinical reality?
46. Activation of p38 and c-Jun NH2-terminal kinase pathways and inhibition of apoptosis by chelerythrine do not require inhibition of protein kinase C
47. ATP channels