Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TGε26 mice leading to the prevention of colitis

Gut

Volumn 54, Issue 2, 2005, Pages 207-214

  Veltkamp, C ^a   Sartor, R B ^b   Giese, T ^a   Autschbach, F ^a   Kaden, I ^a   Veltkamp, R ^a   Rost, D ^a   Kallinowski, B ^a   Stremmel, W ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CELL CULTURE; CELL TRANSFER; COLITIS; CONTROLLED STUDY; CYTOKINE RELEASE; HISTOLOGY; INFLAMMATION; MESENTERY LYMPH NODE; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAINING; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMUS;

ANIMALS; BONE MARROW TRANSPLANTATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COLITIS; LYMPH NODES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE TRANSFUSION; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 12344304166     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2004.046953     Document Type: Article

References (42)

1. Garside P, Mowat AM. Oral tolerance. Semin Immunol 2001;13:177-85.
2. Sartor RB. Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases. Am J Gastroenterol 1997;92:5S-11.
3. Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol 2002;20:495-549.
4. Mizoguchi A, Mizoguchi E, Bhan AK. Immune networks in animal models of inflammatory bowel disease. Inflamm Bowel Dis 2003;9:246-59.
5. Veltkamp C, Tonkonogy SL, De Yong YP, et al. Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg26 mice. Gastroenterology 2001;120:900-13.
6. Cong Y, Brandwein SL, McCabe RP, et al. CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med 1998;187:855-64.
7. Duchmann R, Kaiser I, Herrmann E, et al. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 1995;102:448-55.
8. Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-64.
9. Suri-Payer E, Amar AZ, Thornton AM, et al. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol 1998;160:1212-18.
10. Annacker O, Pimenta-Araujo R, Burlen-Defranoux O, et al. CD25+CD4+ T cells regulate the expansion of peripheral CD4+ T cells through the production of IL-10. J Immunol 2001;166:3008-18.
11. Murakami M, Sakamoto A, Bender J, et al. CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc Natl Acad Sci U S A 2002;99:8832-7.
12. Kingsley CI, Karim M, Bushell AR, et al. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002;168:1080-6.
13. Choen JL, Trenado A, Vasey D, et al. CD4+CD25+ immunoregulatory T cells: new therapeutics for graft-versus-host disease. J Exp Med 2002;196:401-6.
14. Edinger M, Hoffmann P, Ermann J, et al. CD4+CD25+ regulatory T cells preserve graft versus tumor activity while inhibiting graft-versus-host-disease after bone marrow transplantation. Nat Med 2003;9:1144-50.
15. Asano M, Toda M, Sakaguchi N, et al. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996;184:387-96.
16. Jordan MS, Boesteanu A, Reed AJ, et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001;2:301-6.
17. Ludviksson BR, Gray B, Strober W, et al. Dysregulated intrathymic development in the IL-2-deficient mouse leads to colitis-inducing thymocytes. J Immunol 1997;158:104-11.
18. Powrie F, Leach MW, Mauze S, et al. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C.B-17 scid mice. Int Immunol 1993;5:1461-71.
19. Morrissey PJ, Charrier K, Braddy S, et al. CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice: disease development is prevented by cotransfer of purified CD4+ cells. J Exp Med 1993;178:237-44.
20. Heike Y, Ohira T, Takahashi M, et al. Long-term human hematopoiesis in SCID-hu mice bearing transplanted fragments of adult bone and bone marrow cells. Blood 1995;86:524-30.
21. Blazor BR, Taylor PA, McElmurry R, et al. Engraftment of severe combined immune deficient mice receiving allogeneic bone marrow via in utero or postnatal transfer. Blood 1998;92:3949-59.
22. Hollonder GA, Wang B, Nichogiannopoulo A, et al. Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes. Nature 1995;373:350-3.
23. Hollander GA, Simpson SJ, Mizoguchi E, et al. Severe colitis in mice with aberrant thymic selection. Immunity 1995;3:27-38.
24. Rath HC, Herfarth HH, Ikeda JS, et al. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis and arthritis in HLA-B27/humanβ2 microglobulin transgenic rats. J Clin Invest 1996;98:945-53.
25. Tonkonogy SL, Sartor RB. Immune system activation in C3H/HeHBir mice exhibiting spontaneous ulceration. Inflamm Bowel Dis 1997;3:10-19.
26. Simpson SJ, Hollander GA, Mizoguchi E, et al. Expression of proinflammatory cytokines by TCRαβ+ and TCRγδ+ T cells in an experimental model of colitis. Eur J Immunol 1997;27:17-25.
27. Mackay F, Browning JL, Lawton P, et al. Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis. Gastroenterology 1998;115:1464-75.
28. Levings MK, Sangregorio R, Sartirana C, et al. Human CD25+CD4+ T suppressor cell clones produce transforming growth factor β, but not interleukin 10, and are distinct from type 1 regulatory T cells. J Exp Med 2002;196:1335-46.
29. Nakamura K, Kitani A, Fuss I, et al. TGF-beta1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol 2004;172:834-42.
30. Kullberg MC, Jankovic D, Gorelick PL, et al. Bacteria-triggered CD4+ T regulatory cells suppress Helicobacter hepaticus-induced colitis. J Exp Med 2002;196:505-15.
31. Maul J, Zeitz M, Duchmann R. Regulatory CD4+CD25 high T cells are increased in inactive and decreased in active inflammatory bowel disease. Gastroenterology 2002;122:M1094.
32. Read S, Malmström V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation. J Exp Med 2000;192:295-302.
33. Mottet C, Uhlig HH, Powrie F. Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 2003;170:3939-43.
34. Erdman SE, Poutahidis T, Tomczak M, et al. CD4+CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. Am J Pathol 2003;162:691-702.
35. Asseman C, Read S, Powrie F. Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10. J Immunol 2003;171:971-8.
36. Foussat A, Cottrez F, Brun V, et al. A comparative study between T regulatory type 1 and CD4+CD25+ T cells in the control of inflammation. J Immunol 2003;171:5018-26.
37. Dieckmann D, Plottner H, Berchtold S, et al. Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood. J Exp Med 2001;193:1303-10.
38. Green EA, Gorelik L, Mc Gregor CM, et al. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci USA 2003;100:10878-83.
39. Chen WJ, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25-naïve T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 2003;198:1875-86.
40. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-61.
41. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-6.
42. Pettersson FE, Schneider MK, Andrsson J, et al. CD8+ T cells induce medullary thymic epithelium and CD4+CD8+CD25+ TCRbeta- thymocytes in SCID mice. Scand J Immunol 2001;54:506-15.