The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2

Cell Death and Differentiation

Volumn 8, Issue 7, 2001, Pages 725-733

  Schimmer, A D ^a   Hedley, D W ^a   Chow, S ^a   Pham, N A ^a   Chakrabartty, A ^a   Bouchard, D ^a,b   Mak, T W ^a,b   Trus, M R ^a   Minden, M D ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b AMGEN INSTITUTE   (Canada)

Author keywords

Alpha helix; Apoptosis; Bcl 2; Caspases; Mitochondria

Indexed keywords

HYBRID PROTEIN; PEPTIDE; PROTEIN BAD; PROTEIN BCL 2;

ALPHA HELIX; ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CELL CULTURE; CELL DEATH; COLONY FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG RESISTANCE; HUMAN; HUMAN CELL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TARGETING;

AMINO ACID SEQUENCE; ANTENNAPEDIA HOMEODOMAIN PROTEIN; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CARRIER PROTEINS; CASPASE 3; CASPASES; CIRCULAR DICHROISM; ENZYME ACTIVATION; FEMALE; HELA CELLS; HOMEODOMAIN PROTEINS; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; P-GLYCOPROTEIN; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE; TRANSCRIPTION FACTORS;

ANIMALIA; FORMICIDAE;

EID: 0034915150     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400870     Document Type: Article

References (33)

1. Regulation of clinical chemoresistance by bcl-2 and bax oncoproteins in B-cell chronic lymphocytic leukaemia
2. Response to interferon therapy in patients with multiple myeloma correlates with expression of Bcl-2 oncoprotein
3. Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression
4. Modulation of Bcl-2 protein levels by intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7
5. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
6. Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-xL
7. BH3 domain of BAD is required for heterodimerization with Bcl-xL and pro-apoptotic activity
8. Cell permeable Bcl-2 binding peptides: A chemical approach to apoptosis induction in tumor cells
9. Design of model amphipathic peptides having potent antimicrobial action
10. All-D-magainin: Chirality, antimicrobial activity and proteolytic resistance
11. Insertion and orientation of a synthetic peptide representing the C-terminus of the A1 domain of Shiga toxin into phospholipid membranes
12. Anti-cancer activity of targeted pro-apoptotic peptide
13. Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent
14. The third helix of the Antennapedia homeodomain translocates through biological membranes
15. The efficient and rapid import of a peptide into primary B and T lymphocytes and a lymphoblastoid cell line
16. Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia: Prognostic implications
17. Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis
18. Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), II-4, and interferon-gamma in normal human T lymphocytes
19. Linear and cyclic peptides as substrates and modulators of P-glycoprotein: Peptide binding and effects on drug transport and accumulation
20. Interaction of the P-glycoprotein multidrug transporter with peptides and ionophores
21. Bad, a heterodimeric partner for Bcl-xL and Bcl-2 displaces Bax and promotes cell death
22. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not Bcl-xL
23. The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187
24. The mitochondrial permeability transition in cell death; a common mechanism in necrosis, apoptosis and autophagy
25. Intracellular ATP levels determine cell death fate by apoptosis or necrosis
26. Interaction of bioactive hydrophobic peptides with the human multidrug transporter
27. Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport
28. Human MDR1 protein overexpression delays the apoptotic cascade in Hinese hamster ovary fibroblasts
29. P-glycoprotein protects leukemic cells against caspase-dependent, but not caspase-independent cell death
30. Spectroscopic determination of tryptophan and tyrosine in proteins
31. Simultaneous detection of mitochondrial respiratory chain activity and reactive oxygen in digitonin permeabilized cells using flow cytometry
32. An oxidative stress mediated death pathway in irradiated human leukemia cells mapped using multilaser flow cytometry
33. Differential requirement for caspase-9 in apoptotic pathways in vivo