Mammary epithelial cell-cycle progression via the α2β1 integrin: Unique and synergistic roles of the α2 cytoplasmic domain

American Journal of Pathology

Volumn 159, Issue 3, 2001, Pages 983-992

  Klekotka, Paul A ^a   Santoro, Samuel A ^a   Ho, Alan ^b   Dowdy, Steven F ^b   Zutter, Mary M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTEGRIN; BETA1 INTEGRIN; COLLAGEN TYPE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN E; INSULIN; INSULIN RECEPTOR; INTEGRIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST EPITHELIUM; CELL ADHESION; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA SYNTHESIS; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL;

EID: 0034849664     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61774-9     Document Type: Article

References (44)

1. Integrins and signal transduction pathways: The road taken
2. Integrin signaling
3. Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1
4. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein
5. Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors
6. Dependence of cyclin E-CDK2 kinase activity on cell anchorage
7. Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen
8. The membrane glycoprotein la-Ila (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen
9. Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen
10. The alpha 2 beta 1 integrin cell surface collagen receptor binds to the alpha 1 (I)-CB3 peptide of collagen
11. The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin
12. Molecular cloning of the rat integrin alpha 1-subunit: A receptor for laminin and collagen
13. Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes
14. cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, 1 domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues
15. Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins
16. Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells
17. Collagen receptor control of epithelial morphogenesis and cell cycle progression
18. Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(1) gene expression
19. Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail
20. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression
21. Analysis of cell cycle checkpoint status in mammalian cells
22. Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells
23. Widespread histologic distribution of the alpha 2 beta 1 integrin cell-surface collagen receptor
24. The extracellular matrix and mitogenic growth factors control G1 phase cyclin and cyclin-dependent kinase inhibitors
25. Integrin signaling and cell growth control
26. Evolving ideas about cyclins
27. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration
28. Anchorage-dependent regulation of the mitogen-activated protein kinase cascade by growth factors is supported by a variety of integrin alpha chains
29. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
30. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
31. Integrin alpha subunit ratios, cytoplasmic domains, and growth factor synergy regulate muscle proliferation and differentiation
32. Quantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal
33. 1 mediates a unique collagen-dependent proliferation pathway in vivo
34. Anchorage-dependent cell cycle progression
35. Integrins, oncogenes, and anchorage independence
36. Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells
37. Anchorage-dependent transcription of the cyclin A gene
38. Disruption of fibronectin binding to the alpha 5 beta 1 integrin stimulates the expression of cyclin-dependent kinases and DNA synthesis through activation of extracellular signal-regulated kinase
39. Analysis of cyclin E and CDK2 in ovarian cancer: Gene amplification and RNA overexpression
40. Alterations in cell cycle regulation in mouse skin tumors
41. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
42. 1 integrin cell-surface collagen receptor
43. Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast