Chemistry of locked nucleic acids (LNA): Design, synthesis, and bio-physical properties

Letters in Peptide Science

Volumn 10, Issue 3-4, 2003, Pages 237-253

  Wengel, Jesper ^a   Petersen, Michael ^a   Frieden, Miriam ^b   Koch, Troels ^b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b Santaris Pharma AS   (Denmark)

Author keywords

gene inhibition by LNA triplexes; hybridisation kinetics; hybridisation thermodynamics; LNA analogues; LNA diastereoisomers; LNA monomer synthesis; LNA triplexes; LNA DNA RNA double strands; oligomer synthesis; structure of LNA DNA RNA single strands

Indexed keywords

DNA; DOUBLE STRANDED DNA; NUCLEIC ACID; NUCLEOSIDE; OLIGONUCLEOTIDE; RIBONUCLEASE; RNA;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION KINETICS; CHEMISTRY; HYBRIDIZATION; MOLECULAR RECOGNITION; MOLECULE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; SOLUBILITY;

EID: 11144320781     PISSN: 09295666     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02484561     Document Type: Article

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