A 2′,4′-Bridged Nucleic Acid Containing 2-Pyridone as a Nucleobase: Efficient Recognition of a C · G Interruption by Triplex Formation with a Pyrimidine Motif

Angewandte Chemie - International Edition

Volumn 40, Issue 11, 2001, Pages 2079-2081

  Obika, Satoshi ^a   Hari, Yoshiyuki ^a   Sekiguchi, Mitsuaki ^a   Imanishi, Takeshi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001368782     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3773(20010601)40:11<2079::AID-ANIE2079>3.0.CO;2-Z     Document Type: Article

References (20)

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6. We defined BNA as a novel class of nucleic acid analogues containing the 2′-O,4′-C- or 3′-O,4′-C-methylene bridged structure (2′,4′-BNA or 3′,4′-BNA, respectively). The 2′,4′-BNA has also been called "LNA"; see S. K. Singh, P. Nielsen, A. A. Koshkin, J. Wengel. Chem. Commun. 1998, 455-456.
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17. Crystallographic data (excluding structure factors) for the structure reported in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication no. CCDC-152458. Copies of the data can be obtained free of charge on application to CCDC, 12 Union Road. Cambridge CB21EZ, UK (fax; (+44) 1223-336-033; e-mail: deposit@ccdc.cam.ac.uk).
18. B-mC) [M-H] 4490.48 (4491.08).
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20. Recently, Prévot-Halter and Leumann proposed that the 3-nitrogen atom in pyrimidine contributed to the hydrogen bonding of the 4-amino group in C. See ref. [2b].