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Volumn 23, Issue 3, 1998, Pages 417-424

Human liver microsomal metabolism of paclitaxel and drug interactions

Author keywords

Hepatic metabolism drug interactions; Human microsomes; Paclitaxel; R verapamil; Tamoxifen

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; CYCLOSPORIN A; CYTOCHROME P450 ISOENZYME; DOXORUBICIN; DRUG METABOLITE; ETOPOSIDE; KETOCONAZOLE; PACLITAXEL; QUERCETIN; TAMOXIFEN; VERAPAMIL;

EID: 0031795319     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03192303     Document Type: Article
Times cited : (74)

References (31)
  • 1
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol
    • Schiff P.B., Fant J., Horwitz S. (1979) : Promotion of microtubule assembly in vitro by taxol. Nature, 277, 665-667.
    • (1979) Nature , vol.277 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.3
  • 2
    • 0025850566 scopus 로고
    • Sequences of taxol and cisplatin: A phase I and pharmacologic studies
    • Rowinsky E.K., Gilbert M.R., McGuire W.P. et al. (1991) : Sequences of taxol and cisplatin: a phase I and pharmacologic studies. J. Clin. Oncol., 9, 1692-1703.
    • (1991) J. Clin. Oncol. , vol.9 , pp. 1692-1703
    • Rowinsky, E.K.1    Gilbert, M.R.2    McGuire, W.P.3
  • 3
    • 0028051587 scopus 로고
    • Paclitaxel (Taxol)/doxorubicin combinations in advanced breast cancer: The Eastern Cooperative Oncology Group experience
    • Sledge G.W., Robert N., Sparano J.A. et al. (1994) : Paclitaxel (Taxol)/doxorubicin combinations in advanced breast cancer: The Eastern Cooperative Oncology Group experience. Semin. Oncol., 21 (suppl. 8), 15-18.
    • (1994) Semin. Oncol. , vol.21 , Issue.SUPPL. 8 , pp. 15-18
    • Sledge, G.W.1    Robert, N.2    Sparano, J.A.3
  • 4
    • 0030947405 scopus 로고    scopus 로고
    • Paclitaxel-based combination chemotherapy for breast cancer
    • Hortobagyi G.N. (1997) : Paclitaxel-based combination chemotherapy for breast cancer. Oncology, XX, 29-37.
    • (1997) Oncology , vol.20 , pp. 29-37
    • Hortobagyi, G.N.1
  • 5
    • 0027954464 scopus 로고
    • Taxol metabolism by human liver microsomes: Identification of cytochrome P450 isozymes involved in its biotransformation
    • Cresteil T., Monsarrat B., Alvinerie P., Tréluyer J.M.T, Vierira I., Wright M. (1994) : Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation. Cancer Res., 54, 386-392.
    • (1994) Cancer Res. , vol.54 , pp. 386-392
    • Cresteil, T.1    Monsarrat, B.2    Alvinerie, P.3    Tréluyer, J.M.T.4    Vierira, I.5    Wright, M.6
  • 6
    • 0028201724 scopus 로고
    • Cytochrome P450 3A-mediated human liver microsomal taxol 6 alpha-hydroxylation
    • Kumar G.N., Walle U.K., Walle T. (1994) : Cytochrome P450 3A-mediated human liver microsomal taxol 6 alpha-hydroxylation. J. Pharmacol. Exp. Ther., 268, 1160-1165.
    • (1994) J. Pharmacol. Exp. Ther. , vol.268 , pp. 1160-1165
    • Kumar, G.N.1    Walle, U.K.2    Walle, T.3
  • 7
    • 0027957132 scopus 로고
    • Metabolism of Taxol by human hepatic microsomes and liver slices: Participation of cytochrome P450 3A4 and an unknown P450 enzyme
    • Harris J.W., Rahman A., Kim B-R., Guengerich P.P., Collins J.M. (1994) : Metabolism of Taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme. Cancer Res., 54, 4026-4035.
    • (1994) Cancer Res. , vol.54 , pp. 4026-4035
    • Harris, J.W.1    Rahman, A.2    Kim, B.-R.3    Guengerich, P.P.4    Collins, J.M.5
  • 8
    • 0028036727 scopus 로고
    • Selective biotransformation of taxol to 6α-hydroxytaxol by human cytochrome P450 2C8
    • Rahman A., Korekwa K.R., Grogan J., Gonzalez F.J., Harris J.W. (1994) : Selective biotransformation of taxol to 6α-hydroxytaxol by human cytochrome P450 2C8. Cancer Res., 54, 5543-5546.
    • (1994) Cancer Res. , vol.54 , pp. 5543-5546
    • Rahman, A.1    Korekwa, K.R.2    Grogan, J.3    Gonzalez, F.J.4    Harris, J.W.5
  • 11
    • 0028227087 scopus 로고
    • Saturable pharmacokinetics and paclitaxel pharmacodynamics in children with solid tumors
    • Sonnichsen D.S, Hurwitz C.A., Pratt C.B., Shuster J.J., Relling M.V. (1994) : Saturable pharmacokinetics and paclitaxel pharmacodynamics in children with solid tumors. J. Clin. Oncol. 12, 532-538.
    • (1994) J. Clin. Oncol. , vol.12 , pp. 532-538
    • Sonnichsen, D.S.1    Hurwitz, C.A.2    Pratt, C.B.3    Shuster, J.J.4    Relling, M.V.5
  • 12
    • 0028027813 scopus 로고
    • Bioanalysis, pharmacokinetics and pharmacodynamics of the novel anti-cancer drug paclitaxel (Taxol)
    • Beijnen J.H., Huizing M.T., ten Bokkel W.W., et.al. (1994) : Bioanalysis, pharmacokinetics and pharmacodynamics of the novel anti-cancer drug paclitaxel (Taxol). Semin. Oncol., 21 (suppl 8), 53-62.
    • (1994) Semin. Oncol. , vol.21 , Issue.SUPPL. 8 , pp. 53-62
    • Beijnen, J.H.1    Huizing, M.T.2    Ten Bokkel, W.W.3
  • 13
    • 0029165482 scopus 로고
    • Effect of R-verapamil on the pharmacokinetics of paclitaxel in women with breast cancer
    • Berg S.L., Tolcher A., O'Shaughnessy J.A. et al. (1995) : Effect of R-verapamil on the pharmacokinetics of paclitaxel in women with breast cancer. J. Clin. Oncol., 13, 2039-2042.
    • (1995) J. Clin. Oncol. , vol.13 , pp. 2039-2042
    • Berg, S.L.1    Tolcher, A.2    O'Shaughnessy, J.A.3
  • 15
    • 0029061742 scopus 로고
    • Comparative in vitro cytotoxic effects of taxol and its major human metabolite 6α-hydroxypaclitaxel
    • Kumar G., Ray S., Walle T. et.al. (1995) : Comparative in vitro cytotoxic effects of taxol and its major human metabolite 6α-hydroxypaclitaxel. Cancer Chemother. Pharmacol., 36, 129-135.
    • (1995) Cancer Chemother. Pharmacol. , vol.36 , pp. 129-135
    • Kumar, G.1    Ray, S.2    Walle, T.3
  • 16
    • 0024779132 scopus 로고
    • P-glycoprotein: Multidrug resistance and a superfamily of membrane-associated transport proteins
    • Juranka P.F., Zastawny R.I., Ling V. (1989) : P-glycoprotein: multidrug resistance and a superfamily of membrane-associated transport proteins. FASEB J., 3: 2583-2592.
    • (1989) FASEB J. , vol.3 , pp. 2583-2592
    • Juranka, P.F.1    Zastawny, R.I.2    Ling, V.3
  • 18
    • 0027518135 scopus 로고
    • Clinical trials of modulators of multidrug resistance: Pharmacokinetic and pharmacodynamic consideration
    • Lum B.L., Fisher G.A., Brophy N.A. et. al. (1993) : Clinical trials of modulators of multidrug resistance: pharmacokinetic and pharmacodynamic consideration. Cancer, 72, 3502-3514.
    • (1993) Cancer , vol.72 , pp. 3502-3514
    • Lum, B.L.1    Fisher, G.A.2    Brophy, N.A.3
  • 19
    • 0026476078 scopus 로고
    • High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in P-glycoprotein expressing cell lines
    • Stuart N.S.A., Philip P., Harris A.L. et.al. (1992) : High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in P-glycoprotein expressing cell lines. Br. J. Cancer, 66, 833-839.
    • (1992) Br. J. Cancer , vol.66 , pp. 833-839
    • Stuart, N.S.A.1    Philip, P.2    Harris, A.L.3
  • 20
    • 0024654213 scopus 로고
    • A re-appraisal of its pharmacodynamics and pharmacokinetic properties, and therapeutic use
    • Buckley M.M-T., Goa K.L. Tamoxifen. (1989) : A re-appraisal of its pharmacodynamics and pharmacokinetic properties, and therapeutic use. Drugs, 37, 451-490.
    • (1989) Drugs , vol.37 , pp. 451-490
    • Buckley, M.M.-T.1    Tamoxifen, G.K.L.2
  • 21
    • 0030051928 scopus 로고    scopus 로고
    • Metabolism of docetaxel by human cytochrome P450: Interactions with paclitaxel and other anti-neoplastic agents
    • Royer I., Monsarrat B., Sonnier M., Wright M., Cresteil T. (1996) : Metabolism of docetaxel by human cytochrome P450: interactions with paclitaxel and other anti-neoplastic agents. Cancer Res., 56, 58-65.
    • (1996) Cancer Res. , vol.56 , pp. 58-65
    • Royer, I.1    Monsarrat, B.2    Sonnier, M.3    Wright, M.4    Cresteil, T.5
  • 22
    • 0027067753 scopus 로고
    • Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporin in a phase I trial to modulate multidrug resistance
    • Lum B.L., Kaubisch S., Yahanda A.M. et al. (1992) : Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporin in a phase I trial to modulate multidrug resistance. J. Clin. Oncol., 10, 1635-1642.
    • (1992) J. Clin. Oncol. , vol.10 , pp. 1635-1642
    • Lum, B.L.1    Kaubisch, S.2    Yahanda, A.M.3
  • 23
    • 0027221052 scopus 로고
    • Metabolism of the antimammary cancer anti-estrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation
    • Mani C., Gelboin H.V., Park S.S., Pearce R., Parkinson A., Kupfe D. (1993) ; Metabolism of the antimammary cancer anti-estrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation. Drug Metab. Dispos., 21, 645-656.
    • (1993) Drug Metab. Dispos. , vol.21 , pp. 645-656
    • Mani, C.1    Gelboin, H.V.2    Park, S.S.3    Pearce, R.4    Parkinson, A.5    Kupfe, D.6
  • 25
    • 0027761361 scopus 로고
    • Relationship between graft cytochrome P-450 3A content and early morbidity after liver transplantation
    • Lemoine A., Azoulay D., Gries J.M. et.al. (1993) : Relationship between graft cytochrome P-450 3A content and early morbidity after liver transplantation. Transplantation. 56, 1410-1414.
    • (1993) Transplantation , vol.56 , pp. 1410-1414
    • Lemoine, A.1    Azoulay, D.2    Gries, J.M.3
  • 26
    • 0026575467 scopus 로고
    • Platinum anti-cancer drugs modulate P450 mRNA levels and differentially alter hepatic drug and steroid metabolism in male and female rats
    • Leblanc G.A., Sundseth S.S., Weber G.F., Waxman D.J. (1992) : Platinum anti-cancer drugs modulate P450 mRNA levels and differentially alter hepatic drug and steroid metabolism in male and female rats. Cancer Res., 52, 540-547.
    • (1992) Cancer Res. , vol.52 , pp. 540-547
    • Leblanc, G.A.1    Sundseth, S.S.2    Weber, G.F.3    Waxman, D.J.4
  • 28
    • 0029582977 scopus 로고
    • The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: Implication for drug interactions
    • Kivisko K.T., Kroemer H.K., Eichelbaum M. (1995) : The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implication for drug interactions. Br. J. Clin. Pharmacol., 40, 523-530.
    • (1995) Br. J. Clin. Pharmacol. , vol.40 , pp. 523-530
    • Kivisko, K.T.1    Kroemer, H.K.2    Eichelbaum, M.3
  • 29
    • 0026425653 scopus 로고
    • Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment
    • Lien E.A., Solheim E., Ueland P.M. (1991) : Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment. Cancer Res., 51, 4837-4844.
    • (1991) Cancer Res. , vol.51 , pp. 4837-4844
    • Lien, E.A.1    Solheim, E.2    Ueland, P.M.3
  • 30
    • 0020521932 scopus 로고
    • The pharmacology of verapamil. V. Tissue distribution of verapamil and norverapamil in rat and dog
    • Hamann S.R., Todd G.R., McAllister R.G. (1983) : The pharmacology of verapamil. V. Tissue distribution of verapamil and norverapamil in rat and dog. Pharmacology, 27, 1-8.
    • (1983) Pharmacology , vol.27 , pp. 1-8
    • Hamann, S.R.1    Todd, G.R.2    McAllister, R.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.